scholarly journals Effect of Cyclosporin - A on the Lung of Adult Male Albino Rats and The Possible Protective Role of Vitamin E

2021 ◽  
Vol 89 (6) ◽  
pp. 1089-1096
Author(s):  
HALA H.M. MOSSALAM, M.D.; ASMAA F. YOUSUF, M.D.
Keyword(s):  
Vitamin E ◽  
Cyclosporin A ◽  
Adult Male ◽  
Protective Role ◽  
Albino Rats

scholarly journals Effect of tenofovir Administration And Withdrawl On The Kidney Tissues Of Adult Male Albino Rats And The Protective Role Of Vitamin E

2019 ◽  
Vol 2 (2) ◽  
pp. 71-80
Author(s):  
Rasha Abd El-Fattah ◽  
Dorreia Zaghloul ◽  
Eman Abd Elrahim ◽  
Salwa Ouies
Keyword(s):  
Vitamin E ◽  
Adult Male ◽  
Protective Role ◽  
Albino Rats

scholarly journals THE POSSIBLE PROTECTIVE ROLE OF NIGELLA SATIVA OIL AND VITAMIN E AGAINST RADIATION IN ADULT MALE ALBINO RATS

2014 ◽  
Vol 2 (1) ◽  
pp. 1-16
Author(s):  
Marwa Abaza ◽  
Iman Elkhishin ◽  
Ghada Elmesallamy ◽  
Mona Elghazaly
Keyword(s):  
Vitamin E ◽  
Adult Male ◽  
Nigella Sativa ◽  
Protective Role ◽  
Albino Rats ◽  
Nigella Sativa Oil

Effects of erdosteine on cyclosporin-A-induced nephrotoxicity

2011 ◽  
Vol 31 (6) ◽  
pp. 565-573 ◽  
Author(s):  
M Tutanc ◽  
V Arica ◽  
N Yılmaz ◽  
A Nacar ◽  
I Zararsiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cyclosporin A ◽  
Protective Role ◽  
Control Group ◽  
Albino Rats ◽  
Protective Mechanism ◽  
Antioxidant Parameters ◽  
Group 2 ◽  
Wistar Albino Rats

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group 1 rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

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