Regenerative Capacity of Allogenic Gingival Margin-Derived Stem Cells with Fibrin Glue on Albino Rats Partially Dissected Submandibular Salivary Glands

2016 ◽  
Vol 3 (12) ◽  
pp. 37-41
1960 ◽  
Vol 199 (1) ◽  
pp. 63-66 ◽  
Author(s):  
Herbert Wells ◽  
Paul L. Munson

An increase of 12% in fresh and dry weight of the submandibular salivary glands was observed 24 hours after a single amputation of the lower incisor teeth. The effect of repeated amputations was increased by increasing the frequency of amputations and by lengthening the period of amputations. After cessation of a series of amputations, the weight of the hypertrophied salivary glands decreased gradually to approach the control level. Repeated amputation of only one lower incisor tooth was much less effective than amputation of both, and the effect was largely but not entirely restricted to the ipsilateral glands. Ulceration of the adjacent mucosa without amputation of the incisors had no detectable effect on the salivary glands. After amputation of the tips of the incisor teeth without exposure of the pulp or after half-amputations with minimum exposure, the salivary glands increased in weight significantly but much less than after amputation at the gingival margin. It is concluded that the data support the reflex neurological explanation of the phenomenon previously offered by the authors.


1959 ◽  
Vol 196 (4) ◽  
pp. 827-830 ◽  
Author(s):  
Herbert Wells ◽  
S. Jerome Zackin ◽  
Paul Gold-Haber ◽  
Paul L. Munson

Periodic amputation of the erupted portion of the lower incisors of albino rats resulted in a marked increase in the wet and dry weight of the submandibular salivary glands as early as 7 days after the first amputation. Enlargement of both serous and mucous acini was observed, but no effect on the cells of the tubules could be detected. Amputation of the upper incisors alone did not result in enlargement of the submandibular glands. Hypophysectomy decreased the extent of the response to amputation of the lower incisors but did not abolish it. Chronic treatment with cortisone had no significant effect on the weight of the glands. A reflex neurologic explanation was offered as a tentative basis for understanding the phenomenon and as a starting point for further investigation.


2018 ◽  
Vol 64 (2) ◽  
pp. 1293-1303
Author(s):  
Radwa El-sharkawy ◽  
Hala El-kammar ◽  
Raneem Obeid ◽  
Abdelfattah Bdelkhalek

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