Microwave ablation versus Radiofrequency ablation in the management of Hepatocellular carcinoma

Recently, the interventional therapies are used more often in clinical practice for hepatocellular carcinoma. The most commonly used methodologies include radiofrequency ablation, microwave ablation, laser ablation, and cryotherapy. Most of the interventional operations need local anesthesia combined with intravenous sedation. Also, some interventional therapy centers apply general anesthesia. However, different anesthesia methods can cause diverse effects on patients’ pain management, recovery time, and hospitalization time. For the better understanding of the current anesthesia application status, we summarize and analyze multiple anesthesia methods while being applied in interventional therapy for hepatocellular carcinoma; in addition, their characters are also compared in this paper.

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The Combination Strategy of Transarterial Chemoembolization and Radiofrequency Ablation or Microwave Ablation against Hepatocellular Carcinoma

Analytical Cellular Pathology ◽

10.1155/2019/8619096 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Zhentian Xu ◽

Haiyang Xie ◽

Lin Zhou ◽

Xinhua Chen ◽

Shusen Zheng

Keyword(s):

Hepatocellular Carcinoma ◽

Radiofrequency Ablation ◽

Clinical Data ◽

Transarterial Chemoembolization ◽

Microwave Ablation ◽

Great Majority ◽

Intermediate Stage ◽

Combination Strategy ◽

Term Outcome ◽

Long Term Outcome

Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. Hepatectomy and liver transplantation (LT) are regarded as the radical treatment, but great majority of patients are already in advanced stage on the first diagnosis and lose the surgery opportunity. Multifarious image-guided interventional therapies, termed as locoregional ablations, are recommended by various HCC guidelines for the clinical practice. Transarterial chemoembolization (TACE) is firstly recommended for intermediate-stage (Barcelona Clinic Liver Cancer (BCLC) B class) HCC but has lower necrosis rates. Radiofrequency ablation (RFA) is effective in treating HCCs smaller than 3 cm in size. Microwave ablation (MWA) can ablate larger tumor within a shorter time. Combination of TACE with RFA or MWA is effective and promising in treating larger HCC lesions but needs more clinical data to confirm its long-term outcome. The combination of TACE and RFA or MWA against hepatocellular carcinoma needs more clinical data for a better strategy. The characters and advantages of TACE, RFA, MWA, and TACE combined with RFA or MWA are reviewed to provide physician a better background on decision.

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P-23 Microwave ablation versus radiofrequency ablation in BCLC-A hepatocellular carcinoma: A systematic review and meta-analysis of randomized controlled trials

Annals of Oncology ◽

10.1016/j.annonc.2020.04.105 ◽

2020 ◽

Vol 31 ◽

pp. S96-S97

Author(s):

A. Rizzo ◽

A. Ricci ◽

S. Tavolari ◽

C. Felicani ◽

A. Palloni ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Systematic Review ◽

Radiofrequency Ablation ◽

Randomized Controlled Trials ◽

Microwave Ablation ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled

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Percutaneous Ablation-Induced Immunomodulation in Hepatocellular Carcinoma

International Journal of Molecular Sciences ◽

10.3390/ijms21124398 ◽

2020 ◽

Vol 21 (12) ◽

pp. 4398 ◽

Cited By ~ 1

Author(s):

Lucile Dumolard ◽

Julien Ghelfi ◽

Gael Roth ◽

Thomas Decaens ◽

Zuzana Macek Jilkova

Keyword(s):

Hepatocellular Carcinoma ◽

Radiofrequency Ablation ◽

Thermal Ablation ◽

Microwave Ablation ◽

Treatment Options ◽

Ablation Techniques ◽

High Rate ◽

Percutaneous Ablation ◽

Ablative Therapies ◽

Immune Changes

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide and its incidence is rising. Percutaneous locoregional therapies, such as radiofrequency ablation and microwave ablation, are widely used as curative treatment options for patients with small HCC, but their effectiveness remains restricted because of the associated high rate of recurrence, occurring in about 70% of patients at five years. These thermal ablation techniques have the particularity to induce immunomodulation by destroying tumours, although this is not sufficient to raise an effective antitumour immune response. Ablative therapies combined with immunotherapies could act synergistically to enhance antitumour immunity. This review aims to understand the different immune changes triggered by radiofrequency ablation and microwave ablation as well as the interest in using immunotherapies in combination with thermal ablation techniques as a tool for complementary immunomodulation.

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