scholarly journals Assessing bottled water nitrate concentrations to evaluate total drinking water nitrate exposure and risk of birth defects

2014 ◽  
Vol 12 (4) ◽  
pp. 755-762 ◽  
Author(s):  
Peter J. Weyer ◽  
Jean D. Brender ◽  
Paul A. Romitti ◽  
Jiji R. Kantamneni ◽  
David Crawford ◽  
...  
Keyword(s):  
Drinking Water ◽  
Water Use ◽  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Heart Defects ◽  
Maternal Exposure ◽  
Bottled Water ◽  
Nitrate Concentrations ◽  
Limb Deficiencies

Previous epidemiologic studies of maternal exposure to drinking water nitrate did not account for bottled water consumption. The objective of this National Birth Defects Prevention Study (NBDPS) (USA) analysis was to assess the impact of bottled water use on the relation between maternal exposure to drinking water nitrate and selected birth defects in infants born during 1997–2005. Prenatal residences of 1,410 mothers reporting exclusive bottled water use were geocoded and mapped; 326 bottled water samples were collected and analyzed using Environmental Protection Agency Method 300.0. Median bottled water nitrate concentrations were assigned by community; mothers' overall intake of nitrate in mg/day from drinking water was calculated. Odds ratios for neural tube defects, limb deficiencies, oral cleft defects, and heart defects were estimated using mixed-effects models for logistic regression. Odds ratios (95% CIs) for the highest exposure group in offspring of mothers reporting exclusive use of bottled water were: neural tube defects [1.42 (0.51, 3.99)], limb deficiencies [1.86 (0.51, 6.80)], oral clefts [1.43 (0.61, 3.31)], and heart defects [2.13, (0.87, 5.17)]. Bottled water nitrate had no appreciable impact on risk for birth defects in the NBDPS.

Maternal Exposure to Nitrate from Drinking Water and Diet and Risk for Neural Tube Defects

2001 ◽  
Vol 153 (4) ◽  
pp. 325-331 ◽  
Author(s):  
Lisa A. Croen ◽  
Karen Todoroff ◽  
Gary M. Shaw
Keyword(s):  
Drinking Water ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Maternal Exposure

scholarly journals Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans

Scientifica ◽  
2017 ◽  
Vol 2017 ◽  
pp. 1-29 ◽  
Author(s):  
Siti W. Mohd-Zin ◽  
Ahmed I. Marwan ◽  
Mohamad K. Abou Chaar ◽  
Azlina Ahmad-Annuar ◽  
Noraishah M. Abdul-Aziz
Keyword(s):  
Central Nervous System ◽  
Animal Model ◽  
Spina Bifida ◽  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Congenital Heart ◽  
Review Paper ◽  
Heart Defects ◽  
Central Nervous System Malformation

Spina bifida is among the phenotypes of the larger condition known as neural tube defects (NTDs). It is the most common central nervous system malformation compatible with life and the second leading cause of birth defects after congenital heart defects. In this review paper, we define spina bifida and discuss the phenotypes seen in humans as described by both surgeons and embryologists in order to compare and ultimately contrast it to the leading animal model, the mouse. Our understanding of spina bifida is currently limited to the observations we make in mouse models, which reflect complete or targeted knockouts of genes, which perturb the whole gene(s) without taking into account the issue of haploinsufficiency, which is most prominent in the human spina bifida condition. We thus conclude that the need to study spina bifida in all its forms, both aperta and occulta, is more indicative of the spina bifida in surviving humans and that the measure of deterioration arising from caudal neural tube defects, more commonly known as spina bifida, must be determined by the level of the lesion both in mouse and in man.

scholarly journals Mengenal Spina Bifida dan Pencegahannya

2021 ◽  
Vol 1 (12) ◽  
pp. 896-903
Author(s):  
Genta Faesal Atsani ◽  
Zanetha Mauly Ilawanda ◽  
Ilma Fahira Basyir
Keyword(s):  
Spina Bifida ◽  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Congenital Abnormality ◽  
Congenital Abnormalities ◽  
Folic Acid Supplementation ◽  
Online Portal ◽  
The Brain ◽  
Developing Spinal Cord

Neural tube defects (NTD) are one of the birth defects or congenital abnormalities that occur in the brain and spine, and commonly find in newborns worldwide. Anencephaly and spina bifida are the two prevalent forms of NTD. The incidence of spina bifida happen on average 1 in 1000 cases of birth worldwide and there are 140,000 cases per year worldwide. Source searches were carried out on the online portal of journal publications as many as 20 sources from MedScape, Google Scholar and the Nation Center for Biotechnology Information / NCBI with the keywords “Neural tube defects (NTD), prevention, and spina bifida”. Spina bifida is a congenital abnormality that occurs in the womb due to a failure of closing process the neural tube during the first few weeks of embryonic development which causes the spine not completely close around the developing spinal cord nerves. NTD can ensue multifactorial conditions such as genetic, environmental, and folate deficiency. The use of folic acid supplementation starting at least 3 months before pregnancy, those are 400 mcg (0.4 mg) per day and 800 mcg per day during pregnancy can reduce the risk of developing neural tube defects such as spina bifida. Generally, spina bifida is undertaking by surgery and the regulation of patients comorbid. Public can find out prevention to avoid or reduce the risk of spina bifida so that the incidence of spina bifida can decrease along with the increasing awareness of the community regarding this disease.

Visualizing the Research Hotspots and Emerging Trends in Neural Tube Defects: A Review

2020 ◽  
Author(s):  
Baohong MAO ◽  
Chichen ZHANG ◽  
Liping YANG ◽  
Yanxia WANG ◽  
Chunhui SU ◽  
...  
Keyword(s):  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Visualization Analysis ◽  
Emerging Trends ◽  
Bibliographic Records ◽  
Tremendous Progress ◽  
Number Of Publications ◽  
Research Domain ◽  
Research Hotspots

Background: Neural tube defects (NTDs) are among the second most common serious birth defects and constitute a major cause of infant death. Research about NTDs has achieved tremendous progress over the last 50 years. Methods: Visualization analysis has been used to explore the hot topic and their emerging trends in NTDs research domain. The scientific literature of research for NTDs has been retrieved from Web of Science™ Core Collection (1966–2014) databases, and final acquire 9125 related bibliographic records, then analyze time trend, distribution of journals, hot keywords, and try to explore the hot topic and their emerging trends in NTDs research domain using Histcite and CiteSpace. Results: The number of publications about NTDs have shown an increased tendency over the last 50 years although there was on a slight decline. Birth Defects Research Part A published the most articles on NTDs research, followed by Lance and Teratology, and the Lancet had the greatest number of total citations. The largest cited frequency keywords was the “Folate”, followed by “Pregnancy”, “Prevention”, and “Spina bifida”. The research hotspots in NTDs research were homocysteine, anencephaly, and screening. Conclusion: With the help of visualization analysis, we explore a quantitative and efficient way of understanding the NTDs knowledge field.   Keywords: Visualization analysis; Neural tube defects; Scientometrics; CiteSpace

scholarly journals Drinking water treatment is not associated with an observed increase in neural tube defects in mice

2014 ◽  
Vol 186 (6) ◽  
pp. 3717-3724 ◽  
Author(s):  
Vanessa E. Melin ◽  
David W. Johnstone ◽  
Felicia A. Etzkorn ◽  
Terry C. Hrubec
Keyword(s):  
Drinking Water ◽  
Water Treatment ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Drinking Water Treatment
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