scholarly journals Near-term and late biological effects of acute and low-dose-rate continuous gamma-ray exposure in dogs and monkeys

1979 ◽  
Author(s):  
J.F. Spalding ◽  
L.M. Holland
Keyword(s):  
Dose Rate ◽  
Low Dose ◽  
Gamma Ray ◽  
Biological Effects ◽  
Low Dose Rate ◽  
Near Term

scholarly journals Establishment of a low dose rate gamma ray calibration field for environmental radiation monitoring devices

2019 ◽  
Vol 186 (4) ◽  
pp. 538-538
Author(s):  
Munehiko KOWATARI ◽  
Hiroshi YOSHITOMI ◽  
Sho NISHINO ◽  
Yoshihiko TANIMURA ◽  
Tetsuya OHISHI ◽  
...  
Keyword(s):  
Dose Rate ◽  
Low Dose ◽  
Gamma Ray ◽  
Radiation Monitoring ◽  
Environmental Radiation ◽  
Low Dose Rate ◽  
Monitoring Devices

Total Ionizing Dose Response of Hafnium-Oxide Based MOS Devices to Low-Dose-Rate Gamma Ray Radiation Observed by Pulse CV and On-Site Measurements

2017 ◽  
Vol 64 (1) ◽  
pp. 673-682 ◽  
Author(s):  
Yifei Mu ◽  
Ce Zhou Zhao ◽  
Qifeng Lu ◽  
Chun Zhao ◽  
Yanfei Qi ◽  
...  
Keyword(s):  
Dose Rate ◽  
Dose Response ◽  
Hafnium Oxide ◽  
Low Dose ◽  
Gamma Ray ◽  
Total Ionizing Dose ◽  
Low Dose Rate ◽  
Mos Devices

Experimental studies on the biological effects of low-dose-rate and low-dose radiation

2008 ◽  
Vol 5 (1) ◽  
pp. 55 ◽  
Author(s):  
Yoichi Oghiso ◽  
Satoshi Tanaka ◽  
Ignacia B. Tanaka III ◽  
Fumiaki Sato
Keyword(s):  
Dose Rate ◽  
Low Dose ◽  
Biological Effects ◽  
Experimental Studies ◽  
Low Dose Radiation ◽  
Low Dose Rate ◽  
Dose Radiation

scholarly journals A Comparison of the Biological Effects of 125I Seeds Continuous Low-Dose-Rate Radiation and 60Co High-Dose-Rate Gamma Radiation on Non-Small Cell Lung Cancer Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0133728 ◽  
Author(s):  
Zhongmin Wang ◽  
Zhenzhen Zhao ◽  
Jian Lu ◽  
Zhijin Chen ◽  
Aiwu Mao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dose Rate ◽  
Low Dose ◽  
Biological Effects ◽  
High Dose Rate ◽  
Small Cell ◽  
High Dose ◽  
Small Cell Lung ◽  
Low Dose Rate ◽  
125I Seeds

The Threshold Effects of Low-Dose-Rate Radiation on miRNA-Mediated Neurodevelopment of Zebrafish

2021 ◽  
Author(s):  
Chu-Qi He ◽  
Liang Mao ◽  
Jin Yao ◽  
Wei-chao Zhao ◽  
Bo Huang ◽  
...  
Keyword(s):  
Dose Rate ◽  
Swimming Speed ◽  
Low Dose ◽  
Threshold Model ◽  
Biological Effects ◽  
Ectopic Expression ◽  
Lateral Line System ◽  
Line System ◽  
Mirna Processing ◽  
Low Dose Rate

The biological effects and regulatory mechanisms of low-dose and low-dose-rate radiation are still rather controversial. Therefore, in this study we investigated the effects of low-dose-rate radiation on zebrafish neurodevelopment and the role of miRNAs in radiation-induced neurodevelopment. Zebrafish embryos received prolonged gamma-ray irradiation (0 mGy/h, 0.1 mGy/h, 0.2 mGy/h, 0.4 mGy/h) during development. Neurodevelopmental indicators included mortality, malformation rate, swimming speed, as well as the morphology changes of the lateral line system and brain tissue. Additionally, spatiotemporal expression of development-related miRNAs (dre-miR-196a-5p, dre-miR-210-3p, dre-miR-338) and miRNA processing enzymes genes (Dicer and Drosha) were assessed by qRT-PCR and whole mount in situ hybridization (WISH). The results revealed a decline in mortality, malformation and swimming speed, with normal histological and morphological appearance, in zebrafish that received 0.1 mGy/h; however, increased mortality, malformation and swimming speed were observed, with pathological changes, in zebrafish that received 0.2 mGy/h and 0.4 mGy/h. The expression of miRNA processing enzyme genes was altered after irradiation, and miRNAs expression was downregulated in the 0.1 mGy/h group, and upregulated in the 0.2 mGy/h and 0.4 mGy/h groups. Furthermore, ectopic expression of dre-miR-210-3p, Dicer and Drosha was also observed in the 0.4 mGy/h group. In conclusion, the effect of low-dose and low-dose-rate radiation on neurodevelopment follows the threshold model, under the regulation of miRNAs, excitatory effects occurred at a dose rate of 0.1 mGy/h and toxic effects occurred at a dose rate of 0.2 mGy/h and 0.4 mGy/h.

scholarly journals Association between low doses of ionizing radiation, administered acutely or chronically, and time to onset of stroke in a rat model

2020 ◽  
Vol 61 (5) ◽  
pp. 666-673
Author(s):  
Norio Takahashi ◽  
Munechika Misumi ◽  
Hideko Murakami ◽  
Yasuharu Niwa ◽  
Waka Ohishi ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Dose Rate ◽  
Low Dose ◽  
Gamma Ray ◽  
Spontaneously Hypertensive Rat ◽  
Onset Time ◽  
High Sensitivity ◽  
Low Dose Rate ◽  
Model Animal

Abstract Exposure to high-doses of ionizing radiation has been reported to be associated with the risk of stroke. However, risks associated with lower dose exposures remain unclear, and there is little information available for the risk modification according to the dose-rate. There are few studies using animal models which might be able to provide complementary information on this association. In this study, the male stroke-prone spontaneously hypertensive rat (SHRSP) was used as a model animal. The rats were acutely irradiated with doses between 0 and 1.0 Gy or chronically irradiated with a cumulative dose of 0.5 or 1.0 Gy (at a dose rate of 0.05 or 0.1 Gy/day, respectively). The onset time of stroke related symptoms in SHRSP was used as an endpoint for evaluating the effects of low dose and the low dose-rate gamma-ray exposures. With respect to acute exposure, the time to the onset of stroke in the irradiated rats suggested the presence of a threshold around 0.1 Gy. For the low dose-rate chronically exposed, no significant increase in stroke symptom was observed. These findings are novel and demonstrate that the SHRSP system can be used to determine the association between the risk of stroke and radiation exposure with high sensitivity. Moreover, these studies provide important information regarding the association between the low dose and low dose-rate radiation exposure and circulatory diseases, especially stroke.

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