Environmental stress mediated changes in transcriptional and translational regulation of protein synthesis in crop plants. Progress report, August 1980-April 1981

Restriction of protein synthesis characterizes human cytomegalovirus (HCMV) latency in the human host. In analyzing the molecular factors that hinder HCMV expression, the present study shows that HCMV genes frequently use 6 rare codons, i.e., GCG (Ala), CCG (Pro), CGT (Arg), CGC (Arg), TCG (Ser), and ACG (Thr). In some instances, the rare host codons are clustered along viral nucleotide sequences and represent the majority in sequences encoding short alanine and proline repeats. Given the positive correlation between codon usage, tRNA content, and protein production, the results support the hypothesis that HCMV usage of rare human codons might hinder HCMV protein synthesis, in this way leading to HCMV latency.

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Transcriptional and translational regulation of gene expression in haploid spermatids

Anatomy and Embryology ◽

10.1007/s004290050245 ◽

1999 ◽

Vol 199 (6) ◽

pp. 471-487 ◽

Cited By ~ 192

Author(s):

Klaus Steger

Keyword(s):

Gene Expression ◽

Translational Regulation ◽

Regulation Of Gene Expression ◽

Transcriptional And Translational Regulation

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Translational regulation of ribosomal protein synthesis during xenopus development

Cell Differentiation and Development ◽

10.1016/0922-3371(89)90661-8 ◽

1989 ◽

Vol 27 ◽

pp. 219

Author(s):

B. Cardinali ◽

C. Bagni ◽

F. Amaldi ◽

N. Campioni ◽

P. Mariottini ◽

...

Keyword(s):

Protein Synthesis ◽

Ribosomal Protein ◽

Translational Regulation ◽

Xenopus Development ◽

Ribosomal Protein Synthesis

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Post-transcriptional and translational regulation modulates gene co-expression behavior in more synchronized pace to carry out molecular function in the cell

Gene ◽

10.1016/j.gene.2016.04.055 ◽

2016 ◽

Vol 587 (2) ◽

pp. 163-168

Author(s):

Jinzeng Wang ◽

Qi Lv ◽

Xujuan Li ◽

Ya Liu ◽

Kang Liu ◽

...

Keyword(s):

Translational Regulation ◽

Molecular Function ◽

Expression Behavior ◽

Transcriptional And Translational Regulation

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INFLUENCE OF THE PHYSICAL STATE OF CHROMATIN ON NUCLEIC ACID AND PROTEIN SYNTHESIS AND ON RADIATION SENSITIVITY OF CELL DIVISION. Progress Report, September 1, 1968--August 31, 1969.

10.2172/4785401 ◽

1969 ◽

Author(s):

M. E. Gaulden

Keyword(s):

Protein Synthesis ◽

Cell Division ◽

Nucleic Acid ◽

Physical State ◽

Radiation Sensitivity ◽

Progress Report

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Role of CDK1 in Translational Regulation in the M-Phase

10.20944/preprints202004.0530.v1 ◽

2020 ◽

Author(s):

Jaroslav Kalous ◽

Denisa Jansova ◽

Andrej Susor

Keyword(s):

Cell Cycle ◽

Protein Synthesis ◽

Translational Regulation ◽

Gene Expression Regulation ◽

Translational Initiation ◽

Initiation Factors ◽

Cellular Events ◽

M Phase ◽

Mitosis And Meiosis

Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when evidence was found that CDK1 is involved in many cellular events that are essential for cell proliferation and survival. In this review we summarize the involvement of active CDK1 in the initiation and elongation steps of protein synthesis in eukaryotes. During its activation CDK1 influences the initiation of protein synthesis, promotes the activity of specific translational initiation factors and affects the functioning of a subset of elongation factors. Our review provides insights into gene expression regulation during the transcriptionally silent cell cycle/M-phase and describes quantitative and qualitative translational changes based on the extramitotic role of the cell cycle master regulator CDK1, to optimize temporal synthesis of proteins to sustain division-related processes: mitosis and cytokinesis.

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