Challenges in the Design of Clinically Useful Brain-targeted Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

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Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

Polymers ◽

10.3390/polym12081832 ◽

2020 ◽

Vol 12 (8) ◽

pp. 1832 ◽

Cited By ~ 1

Author(s):

Ylenia Jabalera ◽

Francesca Oltolina ◽

Ana Peigneux ◽

Alberto Sola-Leyva ◽

Maria P. Carrasco-Jiménez ◽

...

Keyword(s):

Magnetic Field ◽

Drug Delivery ◽

Magnetic Nanoparticles ◽

Targeted Drug Delivery ◽

Magnetic Hyperthermia ◽

Simultaneous Application ◽

Biomimetic Nanoparticles ◽

Targeted Drug ◽

Model Drug ◽

Drug Nanocarriers

The design of novel nanomaterials that can be used as multifunctional platforms allowing the combination of therapies is gaining increased interest. Moreover, if this nanomaterial is intended for a targeted drug delivery, the use of several guidance methods to increase guidance efficiency is also crucial. Magnetic nanoparticles (MNPs) allow this combination of therapies and guidance strategies. In fact, MNPs can be used simultaneously as drug nanocarriers and magnetic hyperthermia agents and, moreover, they can be guided toward the target by an external magnetic field and by their functionalization with a specific probe. However, it is difficult to find a system based on MNPs that exhibits optimal conditions as a drug nanocarrier and as a magnetic hyperthermia agent. In this work, a novel nanoformulation is proposed to be used as a multifunctional platform that also allows dual complementary guidance. This nanoformulation is based on mixtures of inorganic magnetic nanoparticles (M) that have been shown to be optimal hyperthermia agents, and biomimetic magnetic nanoparticles (BM), that have been shown to be highly efficient drug nanocarriers. The presence of the magnetosome protein MamC at the surface of BM confers novel surface properties that allow for the efficient and stable functionalization of these nanoparticles without the need of further coating, with the release of the relevant molecule being pH-dependent, improved by magnetic hyperthermia. The BM are functionalized with Doxorubicin (DOXO) as a model drug and with an antibody that allows for dual guidance based on a magnetic field and on an antibody. The present study represents a proof of concept to optimize the nanoformulation composition in order to provide the best performance in terms of the magnetic hyperthermia agent and drug nanocarrier.

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Multifunctional Fe3O4–CdTe@SiO2–carboxymethyl chitosan drug nanocarriers: synergistic effect towards magnetic targeted drug delivery and cell imaging

New Journal of Chemistry ◽

10.1039/c3nj01207g ◽

2014 ◽

Vol 38 (2) ◽

pp. 700-708 ◽

Cited By ~ 30

Author(s):

Guannan Wang ◽

Li Jin ◽

Yukuan Dong ◽

Lu Niu ◽

Yaxue Liu ◽

...

Keyword(s):

Drug Delivery ◽

Synergistic Effect ◽

Targeted Drug Delivery ◽

Cell Imaging ◽

Carboxymethyl Chitosan ◽

Targeted Drug ◽

Drug Nanocarriers

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Magnetic Fe3O4–graphene composites as targeted drug nanocarriers for pH-activated release

Nanoscale ◽

10.1039/c2nr33158f ◽

2013 ◽

Vol 5 (3) ◽

pp. 1143 ◽

Cited By ~ 104

Author(s):

Xiujuan Fan ◽

Guozheng Jiao ◽

Wei Zhao ◽

Pengfei Jin ◽

Xin Li

Keyword(s):

Targeted Drug ◽

Drug Nanocarriers ◽

Magnetic Fe3o4

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Roles of Polyethylene Glycol on the Surface of Nanoparticles for Targeted Drug Delivery

Nanoscale ◽

10.1039/d1nr02065j ◽

2021 ◽

Author(s):

Liwang Shi ◽

Jinqiu Zhang ◽

Man Zhao ◽

Shukun Tang ◽

Xu Cheng ◽

...

Keyword(s):

Drug Delivery ◽

Polyethylene Glycol ◽

Polymeric Material ◽

Targeted Drug Delivery ◽

Rapid Development ◽

Hydrophilic Polymers ◽

Targeted Drug ◽

Drug Nanocarriers

The rapid development of drug nanocarriers has benefited from surface hydrophilic polymers of particles, which has improved the drug's pharmacokinetics. Polyethylene glycol (PEG) is a kind of polymeric material with...

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Magneto-Plasmonic Nanoparticle Grid Biosensor with Enhanced Raman Scattering and Electrochemical Transduction for Development of Nanocarriers for Targeted Delivery of Protected Anticancer Drugs

10.20944/preprints202104.0553.v1 ◽

2021 ◽

Author(s):

Hoda Ilkhani ◽

Chuan-Jian Zhong ◽

Maria Hepel

Keyword(s):

Raman Scattering ◽

Targeted Delivery ◽

Drug Loading ◽

Interparticle Distance ◽

Plasmonic Enhancement ◽

Plasmonic Nanoparticle ◽

Design And Optimization ◽

Enhanced Raman Scattering ◽

Targeted Drug ◽

Drug Nanocarriers

Safe administration of highly cytotoxic chemotherapeutic drugs is a challenging problem in cancer treatment due to the adverse side effects and collateral damage to non-tumorigenic cells. To mitigate these problems, new promising approaches, based on the paradigm of controlled targeted drug delivery (TDD), utilizing drug nanocarriers with biorecognition ability to selectively target neoplastic cells, are being considered in cancer therapy. Herein, we report on the design and testing of a nanoparticle-grid based biosensing platform to aid in the development of new targeted drug nanocarriers. The proposed sensor grid consists of superparamagnetic gold-coated core-shell Fe2Ni@Au nanoparticles, further functionalized with folic acid targeting ligand, model thiolated chemotherapeutic drug doxorubicin (DOX), and a biocompatibility agent, 3,6,-dioxa-octanethiol (DOOT). The employed dual transduction based on electrochemical and enhanced Raman scattering detection have enabled efficient monitoring of the drug loading onto the nanocarriers, attached to the sensor surface, as well as the drug release under simulated intracellular conditions. The grid’s nanoparticles serve here as the model nanocarriers for new TDD systems under design and optimization. The superparamagnetic properties of the Fe2Ni@Au NPs aid in nanoparticles’ handling and constructing a dense sensor grid with high plasmonic enhancement of the Raman signals due to the minimal interparticle distance.

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Co-coating of receptor-targeted drug nanocarriers with anti-phagocytic moieties enhances specific tissue uptake versus non-specific phagocytic clearance

Biomaterials ◽

10.1016/j.biomaterials.2017.08.045 ◽

2017 ◽

Vol 147 ◽

pp. 14-25 ◽

Cited By ~ 8

Author(s):

Joshua Kim ◽

Sauradeep Sinha ◽

Melani Solomon ◽

Edgar Perez-Herrero ◽

Janet Hsu ◽

...

Keyword(s):

Tissue Uptake ◽

Targeted Drug ◽

Specific Tissue ◽

Drug Nanocarriers

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Magneto-Plasmonic Nanoparticle Grid Biosensor with Enhanced Raman Scattering and Electrochemical Transduction for the Development of Nanocarriers for Targeted Delivery of Protected Anticancer Drugs

Nanomaterials ◽

10.3390/nano11051326 ◽

2021 ◽

Vol 11 (5) ◽

pp. 1326

Author(s):

Hoda Ilkhani ◽

Chuan-Jian Zhong ◽

Maria Hepel

Keyword(s):

Raman Scattering ◽

Targeted Delivery ◽

Drug Loading ◽

Interparticle Distance ◽

Plasmonic Enhancement ◽

Plasmonic Nanoparticle ◽

Design And Optimization ◽

Enhanced Raman Scattering ◽

Targeted Drug ◽

Drug Nanocarriers

Safe administration of highly cytotoxic chemotherapeutic drugs is a challenging problem in cancer treatment due to the adverse side effects and collateral damage to non-tumorigenic cells. To mitigate these problems, promising new approaches, based on the paradigm of controlled targeted drug delivery (TDD), and utilizing drug nanocarriers with biorecognition ability to selectively target neoplastic cells, are being considered in cancer therapy. Herein, we report on the design and testing of a nanoparticle-grid based biosensing platform to aid in the development of new targeted drug nanocarriers. The proposed sensor grid consists of superparamagnetic gold-coated core–shell Fe2Ni@Au nanoparticles, further functionalized with folic acid targeting ligand, model thiolated chemotherapeutic drug doxorubicin (DOX), and a biocompatibility agent, 3,6-dioxa-octanethiol (DOOT). The employed dual transduction method based on electrochemical and enhanced Raman scattering detection has enabled efficient monitoring of the drug loading onto the nanocarriers, attaching to the sensor surface, as well as the drug release under simulated intracellular conditions. The grid’s nanoparticles serve here as the model nanocarriers for new TDD systems under design and optimization. The superparamagnetic properties of the Fe2Ni@Au NPs aid in nanoparticles’ handling and constructing a dense sensor grid with high plasmonic enhancement of the Raman signals due to the minimal interparticle distance.

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