scholarly journals The Role of Natural Products on the Discovery of New Drug Candidates for Neurogenerative Disorders

2013 ◽  
pp. 211-280
Keyword(s):  
Natural Products ◽  
Drug Candidates ◽  
New Drug

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders I: Parkinsons Disease

2011 ◽  
Vol 10 (2) ◽  
pp. 239-250 ◽  
Author(s):  
Helineide Cristina Campos ◽  
Miguel Divino da Rocha ◽  
Flavia Pereira Dias Viegas ◽  
Patricia Carolina Nicastro ◽  
Poliana Calve Fossaluzza ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurodegenerative Disorders ◽  
Parkinsons Disease ◽  
Drug Candidates ◽  
New Drug

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders II: Alzheimers Disease

2011 ◽  
Vol 10 (2) ◽  
pp. 251-270 ◽  
Author(s):  
Miguel Divino da Rocha ◽  
Flavia Pereira Dias Viegas ◽  
Helineide Cristina Campos ◽  
Patricia Carolina Nicastro ◽  
Poliana Calve Fossaluzza ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurodegenerative Disorders ◽  
Alzheimers Disease ◽  
Drug Candidates ◽  
New Drug

Antitubercular Marine Natural Products

2018 ◽  
Vol 25 (20) ◽  
pp. 2304-2328 ◽  
Author(s):  
Lishu Wang ◽  
Jungfeng Wang ◽  
Juan Liu ◽  
Yonghong Liu
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Antitubercular Activity ◽  
Marine Resources ◽  
Drug Candidates ◽  
New Drug ◽  
Chemical Constitution

Due to the importance of nature as a source of new drug candidates, the purpose of this article is to emphasize the marine natural products, which exhibit antitubercular activity, published between January 2000 and May 2016, with 138 quotations to 250 compounds obtained from marine resources. These metabolites are organized by chemical constitution and named as simple alkyl lipids derivatives, aromatics derivatives, peptides, alkaloids, terpenoids, steroids, macrolides, and polycyclic polyketides.

scholarly journals 3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6755
Author(s):  
Maria J. Matos ◽  
Eugenio Uriarte ◽  
Lourdes Santana
Keyword(s):  
Medicinal Chemistry ◽  
Review Paper ◽  
Relevant Literature ◽  
Natural Origin ◽  
Drug Candidates ◽  
Heterocyclic Molecules ◽  
The Past ◽  
New Drug ◽  
Privileged Scaffold

3-Phenylcoumarins are a family of heterocyclic molecules that are widely used in both organic and medicinal chemistry. In this overview, research on this scaffold, since 2010, is included and discussed, focusing on aspects related to its natural origin, synthetic procedures and pharmacological applications. This review paper is based on the most relevant literature related to the role of 3-phenylcoumarins in the design of new drug candidates. The references presented in this review have been collected from multiple electronic databases, including SciFinder, Pubmed and Mendeley.

Natural Products in the Process of Finding New Drug Candidates

2004 ◽  
Vol 11 (11) ◽  
pp. 1375-1389 ◽  
Author(s):  
P. Vuorela ◽  
M. Leinonen ◽  
P. Saikku ◽  
P. Tammela ◽  
J.- Rauha ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Candidates ◽  
New Drug

scholarly journals Microbial Natural Products as Potential Inhibitors of SARS-CoV-2 Main Protease (Mpro)

2020 ◽  
Vol 8 (7) ◽  
pp. 970 ◽  
Author(s):  
Ahmed M. Sayed ◽  
Hani A. Alhadrami ◽  
Ahmed O. El-Gendy ◽  
Yara I. Shamikh ◽  
Lassaad Belbahri ◽  
...  
Keyword(s):  
Natural Products ◽  
Protein Complexes ◽  
Binding Free Energy ◽  
Binding Affinities ◽  
Binding Modes ◽  
Drug Candidates ◽  
Main Protease ◽  
Potential Inhibitors ◽  
Microbial Natural Products

The main protease (Mpro) of the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was subjected to hyphenated pharmacophoric-based and structural-based virtual screenings using a library of microbial natural products (>24,000 compounds). Subsequent filtering of the resulted hits according to the Lipinski’s rules was applied to select only the drug-like molecules. Top-scoring hits were further filtered out depending on their ability to show constant good binding affinities towards the molecular dynamic simulation (MDS)-derived enzyme’s conformers. Final MDS experiments were performed on the ligand–protein complexes (compounds 1–12, Table S1) to verify their binding modes and calculate their binding free energy. Consequently, a final selection of six compounds (1–6) was proposed to possess high potential as anti-SARS-CoV-2 drug candidates. Our study provides insight into the role of the Mpro structural flexibility during interactions with the possible inhibitors and sheds light on the structure-based design of anti-coronavirus disease 2019 (COVID-19) therapeutics targeting SARS-CoV-2.

scholarly journals Marine Natural Products Against Tuberculosis

2006 ◽  
Vol 6 ◽  
pp. 847-861 ◽  
Author(s):  
Marcus Vinícius Nora De Souza
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Human Diseases ◽  
Antituberculosis Activity ◽  
Drug Candidates ◽  
New Drug

Natural products represent an outstanding source of compounds that play an important role in the treatment of human diseases. Due to the importance of nature as a source of new drug candidates, the aim of this review is to highlight the marine natural products, which exhibit antituberculosis activity, discovered between 2000 and 2005.

scholarly journals The Evolving Role of Natural Products from the Tropical Rainforests as a Replenishable Source of New Drug Leads

10.5772/59603 ◽  
2015 ◽  
Author(s):  
Ibrahim Jantan ◽  
Syed Nasir Abbas Bukhari ◽  
Mohamed Ali Seyed Mohamed ◽  
Lam Kok Wai ◽  
Mohammed Ahmed Mesaik
Keyword(s):  
Natural Products ◽  
Tropical Rainforests ◽  
New Drug ◽  
Drug Leads

Advances in identification and validation of protein targets of natural products without chemical modification

2016 ◽  
Vol 33 (5) ◽  
pp. 719-730 ◽  
Author(s):  
J. Chang ◽  
Y. Kim ◽  
H. J. Kwon
Keyword(s):  
Natural Products ◽  
Chemical Modification ◽  
Case Studies ◽  
Protein Identification ◽  
Target Protein ◽  
Label Free ◽  
Protein Targets ◽  
Identification Methods ◽  
Drug Candidates ◽  
New Drug

This review focuses on and reports case studies of the latest advances in target protein identification methods for label-free natural products. The integration of newly developed technologies will provide new insights and highlight the value of natural products for use as biological probes and new drug candidates.

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