Sonodynamic Therapy with Metal Complexes: A New Promise in Cancer Therapy

ChemMedChem ◽  
2021 ◽  
Author(s):  
Ashish Kumar Yadav ◽  
Narendra Kumar ◽  
Abdul Talim Khan ◽  
Rajesh Kushwaha ◽  
Samya Banerjee
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes ◽  
Sonodynamic Therapy

scholarly journals Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

2019 ◽  
Vol 20 (2) ◽  
pp. 341 ◽  
Author(s):  
Dik-Lung Ma ◽  
Chun Wu ◽  
Sha-Sha Cheng ◽  
Fu-Wa Lee ◽  
Quan-Bin Han ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Metal Complexes ◽  
Natural Product ◽  
Cancer Care ◽  
Cancer Therapies ◽  
The Future ◽  
Therapy Development ◽  
Enhanced Selectivity

Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.

scholarly journals Metal-Based Nanomaterials Incorporate with Ultrasound as Acceptable Approach towards Cancer Therapy

2021 ◽  
Vol 2 (11) ◽  
pp. 1101-1110
Author(s):  
Xiaoxiao He ◽  
Shiyue Chen ◽  
Xiang Mao
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Water Solubility ◽  
Cancer Diagnostics ◽  
Tissue Penetration ◽  
Sonodynamic Therapy ◽  
Non Invasive ◽  
Functional Composites ◽  
Different Characteristics ◽  
Target Cancer

Among current biological researches, there have a plenty of works related cancer therapy issues by using functional or pure-phased composites in non-invasive strategies. Especially in fabricating anticancer candidates, functional composites are divided into different sorts with different characteristics. Additionally, nanotechnology provides various approaches in utilizing composites’ functionality for cancer diagnostics and therapeutics. Compared with previous Photodynamic Therapy (PDT), Photo-Thermal Therapy (PTT), chemotherapy and radiotherapy, ultrasound is used to activate sonosensitizer to produce cytotoxic Reactive Oxygen Species (ROS) toward target cancer cells. In recent years, the form of Sonodynamic Therapy (SDT) has been making much effort to develop highly efficient metal based Nanomaterials (NMs) as sonosensitizers, which can efficiently generate ROS and has the advantages of deeper tissue penetration. However, the traditional sonosensitizers, such as porphyrins, hypericin, and curcumins suffer from complex synthesis, poor water solubility, and low tumor targeting efficacy. For contrasting this limitation, the metal based inorganic NMs show biocompatibility, controllable physicochemical properties, and ease of achieving multifunctional properties, which greatly expanded their application in SDT. In this review, we systematically summarize the metal based inorganic NMs as carrier of molecular sonosensitizers, and produce ROS under ultrasound. Moreover, the prospects of advanced metal based further materials application are also discussed.

The progresses in curcuminoids-based metal complexes: especially in cancer therapy

2019 ◽  
Vol 11 (9) ◽  
pp. 1035-1056
Author(s):  
Yanan Zhang ◽  
Abdur Rauf Khan ◽  
Manfei Fu ◽  
Yujia Zhai ◽  
Aihua Yu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes

scholarly journals Novel Metals and Metal Complexes as Platforms for Cancer Therapy

2010 ◽  
Vol 16 (16) ◽  
pp. 1813-1825 ◽  
Author(s):  
Michael Frezza ◽  
Sarmad Hindo ◽  
Di Chen ◽  
Andrew Davenport ◽  
Sara Schmitt ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes

scholarly journals A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Chao Liang ◽  
Jiaen Xie ◽  
Shuangling Luo ◽  
Can Huang ◽  
Qianling Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
Simple Structure ◽  
Basic Structure ◽  
High Yield ◽  
Tissue Penetration ◽  
Facile Synthesis ◽  
Sonodynamic Therapy

AbstractAs a basic structure of most polypyridinal metal complexes, [Ru(bpy)3]2+, has the advantages of simple structure, facile synthesis and high yield, which has great potential for scientific research and application. However, sonodynamic therapy (SDT) performance of [Ru(bpy)3]2+ has not been investigated so far. SDT can overcome the tissue-penetration and phototoxicity problems compared to photodynamic therapy. Here, we report that [Ru(bpy)3]2+ is a highly potent sonosensitizer and sonocatalyst for sonotherapy in vitro and in vivo. [Ru(bpy)3]2+ can produce singlet oxygen (1O2) and sono-oxidize endogenous 1,4-dihydronicotinamide adenine dinucleotide (NADH) under ultrasound (US) stimulation in cancer cells. Furthermore, [Ru(bpy)3]2+ enables effective destruction of mice tumors, and the therapeutic effect can reach deep tissues over 10 cm under US irradiation. This work paves a way for polypyridinal metal complexes to be applied to the noninvasive precise sonotherapy of cancer.

scholarly journals Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Zeng Zeng ◽  
Chao Fang ◽  
Ying Zhang ◽  
Cong-Xian Chen ◽  
Yi-Feng Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Treatment ◽  
Therapeutic Agents ◽  
Sonodynamic Therapy ◽  
Therapeutic Modalities ◽  
Normal Functions ◽  
The Past ◽  
Highly Efficient ◽  
Apoptotic Pathways ◽  
Mitochondria Targeting

Mitochondria are the primary organelles which can produce adenosine triphosphate (ATP). They play vital roles in maintaining normal functions. They also regulated apoptotic pathways of cancer cells. Given that, designing therapeutic agents that precisely target mitochondria is of great importance for cancer treatment. Nanocarriers can combine the mitochondria with other therapeutic modalities in cancer treatment, thus showing great potential to cancer therapy in the past few years. Herein, we summarized lipophilic cation- and peptide-based nanosystems for mitochondria targeting. This review described how mitochondria-targeted nanocarriers promoted highly efficient cancer treatment in photodynamic therapy (PDT), chemotherapy, combined immunotherapy, and sonodynamic therapy (SDT). We further discussed mitochondria-targeted nanocarriers’ major challenges and future prospects in clinical cancer treatment.

scholarly journals An Urchin-Shaped Copper-Based Metalloporphyrin Nanosystem as a Sonosensitizer for Sonodynamic Therapy

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 209
Author(s):  
Aiqing Ma ◽  
Hui Ran ◽  
Jiaxing Wang ◽  
Rui Ding ◽  
Chengyu Lu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Charge Transfer ◽  
Cancer Therapy ◽  
Copper Complex ◽  
Intramolecular Charge Transfer ◽  
Oxygen Species ◽  
Sonodynamic Therapy ◽  
Significant Challenge ◽  
Therapy Strategy

Sonodynamic therapy (SDT), as a novel cancer therapy strategy, might be a promising approach due to the depth-penetration property in tissue. Sonosensitizers are the key element for efficient SDT. However, the development of sonosensitizers with strong sonosensitization efficacy is still a significant challenge. Herein, an urchin-shaped copper-based metalloporphyrin liposome nanosystem (FA–L–CuPP) is constructed and identified as an excellent sonosensitizer. Under ultrasound (US) irradiation, FA–L–CuPP can be highly excited to generate several reactive oxygen species (ROS), such as singlet oxygen (1O2) and free radicals (⋅OH). The molecular orbital distribution calculations reveal that a strong intramolecular charge transfer might occur in the CuPP complex under US irradiation, which could afford enough energy to the surrounding O2 and H2O to concert 1O2, O2− and ⋅OH. Working as “ammunitions”, the largely produced ROS can kill 4T1 tumor cells, effectively inhibiting tumor growth. This work provides an urchin-shaped nanosonosensitizer based on a copper complex, which might provide an idea to design a novel sonosensitizer for noninvasive and precise SDT antitumor applications.

scholarly journals Reactive Oxygen Species-Based Nanomaterials for Cancer Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Yingbo Li ◽  
Jie Yang ◽  
Xilin Sun
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Biomedical Applications ◽  
Reactive Oxygen ◽  
Redox Balance ◽  
Oxygen Species ◽  
Sonodynamic Therapy ◽  
Organic Nanomaterials ◽  
Trigger Cell Death

Nanotechnology advances in cancer therapy applications have led to the development of nanomaterials that generate cytotoxic reactive oxygen species (ROS) specifically in tumor cells. ROS act as a double-edged sword, as they can promote tumorigenesis and proliferation but also trigger cell death by enhancing intracellular oxidative stress. Various nanomaterials function by increasing ROS production in tumor cells and thereby disturbing their redox balance, leading to lipid peroxidation, and oxidative damage of DNA and proteins. In this review, we outline these mechanisms, summarize recent progress in ROS-based nanomaterials, including metal-based nanoparticles, organic nanomaterials, and chemotherapy drug-loaded nanoplatforms, and highlight their biomedical applications in cancer therapy as drug delivery systems (DDSs) or in combination with chemodynamic therapy (CDT), photodynamic therapy (PDT), or sonodynamic therapy (SDT). Finally, we discuss the advantages and limitations of current ROS-mediated nanomaterials used in cancer therapy and speculate on the future progress of this nanotechnology for oncological applications.

scholarly journals Metal complexes in cancer therapy – an update from drug design perspective

2017 ◽  
Vol Volume11 ◽  
pp. 599-616 ◽  
Author(s):  
Umar Ndagi ◽  
Ndumiso Mhlongo ◽  
Mahmoud Soliman
Keyword(s):  
Cancer Therapy ◽  
Drug Design ◽  
Metal Complexes ◽  
Design Perspective
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