Recent Advances in Preclinical Studies and Potential Applications of Dendrimers as Drug Carriers in the Central Nervous System

Author(s):  
Mariacristina Gagliardi
2014 ◽  
Vol 33 (04) ◽  
pp. 347-351
Author(s):  
Pedro Tadao Hamamoto Filho ◽  
Vitor César Machado ◽  
Flávio Ramalho Romero ◽  
Luis Gustavo Ducati ◽  
Marco Antônio Zanini ◽  
...  

AbstractBrain metastases are the most common tumors within the central nervous system. Recent advances on diagnosis and treatment modalities have allowed for longer survival. In this paper we review the indication of each modality of treatment: surgery, whole brain radiotherapy and stereotactic radiosurgery, as also recent advances on the knowledge of brain metastases biology that may improve the use of medical treatment and chemotherapy.


2005 ◽  
Vol 19 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Marc R. Mayberg ◽  
Eric LaPresto ◽  
Edwin J. Cunningham

Object Neuroendoscopic approaches to lesions of the central nervous system and spine are limited by the loss of stereoscopic vision and high-fidelity image quality inherent in the operating microscope. Image-guided endoscopy (IGE) and image-guided surgery (IGS) have the potential to overcome these limitations. The goal of this study was to evaluate IGE for its potential applications in neurosurgery. Methods. To determine the feasibility of IGE, a rigid endoscope was tracked using an IGS system that provided navigational data for the endoscope tip and trajectory as well as a computer-generated, three-dimensional, virtual representation of the image provided by the endoscope. The IGE procedure was successfully completed in 14 patients (nine with pituitary adenomas, one with a temporal cavernous malformation, and four with unruptured aneurysms). No complications could be attributed to the procedure. Compared with direct microscopy performed using anatomical landmarks, registration of the endoscope, and virtual image were highly accurate. Conclusions This procedure offers many potential advantages for central nervous system and spinal endoscopy. Advances in IGE may enable its application to regions outside the central nervous system as well.


2005 ◽  
Vol 21 (4) ◽  
pp. 272-293 ◽  
Author(s):  
Chitra Sarkar ◽  
Prabal Deb ◽  
Mehar Chand Sharma

2014 ◽  
Vol 128 (6) ◽  
pp. 879-891 ◽  
Author(s):  
Anna Sophie Berghoff ◽  
Rupert Bartsch ◽  
Adelheid Wöhrer ◽  
Berthold Streubel ◽  
Peter Birner ◽  
...  

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