Condensed Pyridopyrimidines and Pyridopyrazines Containing a Bridgehead Nitrogen Atom: Synthesis, Chemical Properties and Biological Activity

2021 ◽  
Vol 25 ◽  
Author(s):  
Mikhail V. Slivka ◽  
Natali I. Korol
Keyword(s):  
Nitrogen Atom ◽  
Chemical Properties ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Steady Increase ◽  
Chemical Transformations ◽  
Fused Heterocycles ◽  
Methods Of Synthesis ◽  
Number Of Publications ◽  
Bridgehead Nitrogen

: The investigation of effective and green synthetic routes to approach to novel fused heterocycles with pyridopyrimidine and pyridopyrazine scaffolds stirs up broad interest from scientists as they are capable of providing valuable properties such as anticancer and antimicrobial activities and they are proved γ-secretase modulators, polymers, and corrosion inhibitors. This causes a steady increase in the number of publications on titled condensed systems. The present review article summarizes recent literature data from 2010 to 2020 on the methods of synthesis, chemical transformations and biological properties of condensed bicyclic systems of pyridopyrimidine and pyridopyrazine with a bridgehead nitrogen atom to establish the current state of the art in this area.

scholarly journals Synthesis, physico-chemical properties of 3-thio and 3-thio -4-amino derivatives of 1,2,4-triazole

2019 ◽  
pp. 28-44
Author(s):  
V. V. Parchenko
Keyword(s):  
Chemical Properties ◽  
Biological Properties ◽  
Modern Medicine ◽  
Toxic Substances ◽  
Triazole Derivatives ◽  
Synthetic Drugs ◽  
Physico Chemical ◽  
Methods Of Synthesis ◽  
Amino Derivatives ◽  
Derivatives Of

Modern medicine and pharmacy has at its disposal highly efficient synthetic drugs. Large extent of these drugs accounted for derivatives of 1,2,4-triazole. The purpose of the work was an attempt to summarize the literature in recent years related to the methods of synthesis and study of physico-chemical properties 3-thio- and 3-thio-4-amino derivatives of 1,2,4-triazole. Studies national scientists in recent years indicates prospects of the search in this direction, since this class of organic compounds is interest not only to scientists pharmaceutical, medical and veterinary field, but also among researchers of engineering, metallurgical and agricultural areas. 1,2,4-triazole derivatives are also widely used in practice for optical materials, photosensitizers are used as coloring agents, antioxidants, additives for fuels and oils, some of which are widely used as corrosion inhibitors for controlling various pests in agriculture. In addition, 1,2,4-triazole derivatives belong to the class low toxic or essentially non-toxic substances. The presence of a growing number of publications about methods of synthesis, reactions, physico-chemical and biological properties of 1,2,4-triazole, inspires scientists around the world search for perspective molecules of substituted 1,2,4-triazole. It should be noted that in spite of a sufficient amount of information about the derivatives of 1,2,4-triazole, some issues related to the generalization of data in the literature synthesis presented insufficient.

scholarly journals Coordination Properties of the Fungal Metabolite Harzianic Acid Toward Toxic Heavy Metals

Toxics ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 19
Author(s):  
Gaetano De Tommaso ◽  
Maria Michela Salvatore ◽  
Rosario Nicoletti ◽  
Marina DellaGreca ◽  
Francesco Vinale ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Contaminated Soils ◽  
Biological Activities ◽  
Chemical Properties ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Phytopathogenic Fungi ◽  
Tetramic Acid ◽  
Toxic Heavy Metals ◽  
Beneficial Effects

Some Trichoderma strains are known for their capacity to produce harzianic acid, a metabolite belonging to the tetramic acid derivatives. Harzianic acid has interesting biological properties, such as antimicrobial activities against phytopathogenic fungi and promotion of plant growth. It also possesses remarkable chemical properties, including the chelating properties toward essential transition metals, which might be related to the biological activities. Increasing knowledge on chelating properties might be relevant for understanding the various beneficial effects of harzianic acid in the interaction between the producer fungi and plants. In this work, the coordination capacity of harzianic acid was studied to evaluate the formation and stability of complexes formed with toxic heavy metals (i.e., Cd2+, Co2+, Ni2+, and Pb2+), which might have a crucial role in the tolerance of plants growing in metal-contaminated soils and in abiotic stress.

Diselenides and Selenocyanates as Versatile Precursors for the Synthesis of Pharmaceutically Relevant Compounds

2021 ◽  
Vol 18 ◽  
Author(s):  
Marina D. Kostić ◽  
Vera M. Divac
Keyword(s):  
Biological Effects ◽  
Chemical Properties ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Organoselenium Compounds ◽  
Selenium Compounds ◽  
Biologically Relevant ◽  
The Past ◽  
Biologically Relevant Molecules ◽  
Unique Chemical

: Organoselenium chemistry has undergone extensive development during the past decades, mostly due to the unique chemical properties of organoselenium compounds that have been widely explored in a number of synthetic transformations, as well as due to the interesting biological properties of these compounds. Diselenides and selenocyanates constitute the promising classes of organoselenium compounds that possess interesting biological effects and that can be used in the preparation of other selenium compounds. The combination of diselenide and selenocyanate moieties with other biologically relevant molecules (such as heterocycles, steroids, etc.) is a way for the development of compounds with promising pharmaceutical potential. Therefore, the aim of this review is to highlight the recent achievements in the use of diselenides or selenocyanates as precursors for the synthesis of pharmaceutically relevant compounds, preferentially compounds with antitumor and antimicrobial activities.

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