Lysosomotropic Drugs: Pharmacological Tools to Study Lysosomal Function

2018 ◽  
Vol 18 (12) ◽  
pp. 1147-1158 ◽  
Author(s):  
Sandra Pisonero-Vaquero ◽  
Diego Luis Medina
Keyword(s):  
Lysosomal Function

3-Chloro-1, 2-propanediol inhibits autophagic flux by impairment of lysosomal function in HepG2 cells

2020 ◽  
Vol 144 ◽  
pp. 111575 ◽  
Author(s):  
Jing Lu ◽  
Jianing Lu ◽  
Yan Chen ◽  
Zhe Feng ◽  
Shuang Liu ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Autophagic Flux ◽  
Lysosomal Function

scholarly journals Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal

Cell Reports ◽  
2021 ◽  
Vol 35 (2) ◽  
pp. 109000
Author(s):  
Frida Sommer ◽  
Vincenzo Torraca ◽  
Yufei Xie ◽  
Aliede E. in ‘t Veld ◽  
Joost Willemse ◽  
...  
Keyword(s):  
Lysosomal Function

scholarly journals Presenilins: A novel link between intracellular calcium signaling and lysosomal function?

2012 ◽  
Vol 198 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Ilya Bezprozvanny
Keyword(s):  
Calcium Signaling ◽  
Intracellular Calcium ◽  
Transmembrane Proteins ◽  
Catalytic Subunit ◽  
Familial Alzheimer’S Disease ◽  
Lysosomal Function ◽  
Cell Biol ◽  
Intracellular Calcium Signaling ◽  
Lysosomal Acidification ◽  
In Cells

Mutations in presenilins (PS), transmembrane proteins encoding the catalytic subunit of γ-secretase, result in familial Alzheimer’s disease (FAD). Several studies have identified lysosomal defects in cells lacking PS or expressing FAD-associated PS mutations, which have been previously attributed to a function for PS in lysosomal acidification. Now, in this issue, Coen et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201201076) provide a series of results that challenge this idea and propose instead that presenilins play a role in calcium-mediated lysosomal fusion.

scholarly journals TRPML and lysosomal function

2007 ◽  
Vol 1772 (8) ◽  
pp. 851-858 ◽  
Author(s):  
David A. Zeevi ◽  
Ayala Frumkin ◽  
Gideon Bach
Keyword(s):  
Lysosomal Function
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