Screening for Marine Natural Products with Potential as Chemotherapeutics for Acute Myeloid Leukemia

2015 ◽  
Vol 17 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Espen Hansen ◽  
Jeanette H. Andersen
Keyword(s):  
Acute Myeloid Leukemia ◽  
Natural Products ◽  
Marine Natural Products ◽  
Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

Toxins ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 12
Author(s):  
Tania Keiko Shishido ◽  
Rafael Vicentini Popin ◽  
Jouni Jokela ◽  
Matti Wahlsten ◽  
Marli Fatima Fiore ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Natural Products ◽  
Drug Discovery ◽  
Myeloid Leukemia ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Photosynthetic Organisms ◽  
Pharmaceutical Applications ◽  
New Information ◽  
Acute Myeloid

Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments.

scholarly journals Natural Products and Acute Myeloid Leukemia: A Review Highlighting Mechanisms of Action

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1010 ◽  
Author(s):  
Dongwon Hwang ◽  
Minsun Kim ◽  
Hyejin Park ◽  
Myung In Jeong ◽  
Woojin Jung ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Natural Products ◽  
Myeloid Leukemia ◽  
Synergistic Effects ◽  
Chemical Properties ◽  
Natural Compounds ◽  
Laminin Receptor ◽  
Organosulfur Compounds ◽  
Human Telomerase Reverse Transcriptase ◽  
Acute Myeloid

Recent findings have shown great potential of alternative interventions such as immunotherapy and natural products for acute myeloid leukemia (AML). This study aims to review the anti-AML effect of various natural compounds. Natural compounds were classified into five groups: alkaloids, carotenoids, nitrogen-containing compounds, organosulfur compounds or phenolics based on each compound’s chemical properties. Fifty-eight studies were collected and reviewed in this article. Phenolics are the most abundant group to have an apoptotic effect over AML cells, while other groups have also shown significant apoptotic effects. Some compounds induced apoptosis by regulating unique mechanism like human telomerase reverse transcriptase (hTERT) or laminin receptor (67LR), while others modified caspases, poly (adp-ribose) polymerase (PARP) and p53. Further study is required to identify side-effects of potent compounds and the synergistic effects of combination of two or more natural compounds or existing conventional anti-AML drugs to treat this dreadful disease.

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