Recent Advances in Anti-inflammatory Potential of Pyridazinone Derivatives

2016 ◽  
Vol 16 (12) ◽  
pp. 996-1012 ◽  
Author(s):  
Minaxi Saini ◽  
Dinesh Kumar Mehta ◽  
Rina Das ◽  
Gurnam Saini
Keyword(s):  
Recent Advances ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
Industrial Chemical ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal, and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.

scholarly journals Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Qingdong Guan ◽  
Jiguo Zhang
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Inflammatory Cytokines ◽  
Bowel Disease ◽  
Intestinal Inflammation ◽  
Beneficial Effects ◽  
Recent Advances ◽  
Inflammatory Bowel ◽  
Inflammation Targeting ◽  
Anti Inflammatory

Cytokines play an important role in the immunopathogenesis of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, where they drive and regulate multiple aspects of intestinal inflammation. The imbalance between proinflammatory and anti-inflammatory cytokines that occurs in IBD results in disease progression and tissue damage and limits the resolution of inflammation. Targeting cytokines have been novel strategies in the treatment of IBD. Recent studies show the beneficial effects of anticytokine treatments to IBD patients, and multiple novel cytokines are found to be involved in the pathogenesis of IBD. In this review, we will discuss the recent advances of novel biologics in clinics and clinical trials, and novel proinflammatory and anti-inflammatory cytokines found in IBD with focusing on IL-12 family and IL-1 family members as well as their relevance to the potential therapy of IBD.

scholarly journals Recent Advances in Nonsteroidal Anti-Inflammatory Drugs

2005 ◽  
Vol 54 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Shinichi Kawai ◽  
Fumiaki Kojima ◽  
Natsuko Kusunoki
Keyword(s):  
Recent Advances ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Synthesis of Some New 3(2H)-Pyridazinone Derivatives and Evaluation of their Analgesic-anti-inflammatory and Antimicrobial Activities

2013 ◽  
Vol 10 (6) ◽  
pp. 507-514 ◽  
Author(s):  
Murat Sukuroglu ◽  
Cem Yamali ◽  
Didem Tiryaki ◽  
Fatma Kaynak Onurdag ◽  
Esra Akkol ◽  
...  
Keyword(s):  
Antimicrobial Activities ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

scholarly journals Recent Advances in Nanoparticle-Mediated Delivery of Anti-Inflammatory Phytocompounds

2017 ◽  
Vol 18 (4) ◽  
pp. 709 ◽  
Author(s):  
Raffaele Conte ◽  
Valentina Marturano ◽  
Gianfranco Peluso ◽  
Anna Calarco ◽  
Pierfrancesco Cerruti
Keyword(s):  
Recent Advances ◽  
Anti Inflammatory
Sign in / Sign up

Export Citation Format

Share Document