scholarly journals Current State and Future Perspectives in QSAR Models to Predict Blood- Brain Barrier Penetration in Central Nervous System Drug R&D

2017 ◽  
Vol 17 (3) ◽  
pp. 247-257 ◽  
Author(s):  
Juan F. Morales ◽  
Sebastian Scioli Montoto ◽  
Pietro Fagiolino ◽  
Maria E. Ruiz
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Future Perspectives ◽  
Central Nervous System Drug ◽  
Current State ◽  
Blood Brain ◽  
Barrier Penetration ◽  
Qsar Models

scholarly journals Breast Cancer Brain Metastasis—Overview of Disease State, Treatment Options and Future Perspectives

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1078
Author(s):  
Chikashi Watase ◽  
Sho Shiino ◽  
Tatsunori Shimoi ◽  
Emi Noguchi ◽  
Tomoya Kaneda ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Radiation Therapy ◽  
Brain Metastasis ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Future Perspectives ◽  
Blood Brain ◽  
The Central Nervous System

Breast cancer is the second most common origin of brain metastasis after lung cancer. Brain metastasis in breast cancer is commonly found in patients with advanced course disease and has a poor prognosis because the blood–brain barrier is thought to be a major obstacle to the delivery of many drugs in the central nervous system. Therefore, local treatments including surgery, stereotactic radiation therapy, and whole-brain radiation therapy are currently considered the gold standard treatments. Meanwhile, new targeted therapies based on subtype have recently been developed. Some drugs can exceed the blood–brain barrier and enter the central nervous system. New technology for early detection and personalized medicine for metastasis are warranted. In this review, we summarize the historical overview of treatment with a focus on local treatment, the latest drug treatment strategies, and future perspectives using novel therapeutic agents for breast cancer patients with brain metastasis, including ongoing clinical trials.

scholarly journals Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery

NeuroRx ◽  
2005 ◽  
Vol 2 (4) ◽  
pp. 554-571 ◽  
Author(s):  
Mohammad S. Alavijeh ◽  
Mansoor Chishty ◽  
M. Zeeshan Qaiser ◽  
Alan M. Palmer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Discovery ◽  
Drug Metabolism ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Central Nervous System Drug ◽  
Blood Brain

scholarly journals Central nervous system delivery of molecules across the blood-brain barrier

2021 ◽  
pp. 104952
Author(s):  
Fabien Gosselet ◽  
Rodrigo Azevedo Loiola ◽  
Anna Roig ◽  
Anna Rosell ◽  
Maxime Culot
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models

Physiology ◽  
1998 ◽  
Vol 13 (6) ◽  
pp. 287-293 ◽  
Author(s):  
Gerald A. Grant ◽  
N. Joan Abbott ◽  
Damir Janigro
Keyword(s):  
Central Nervous System ◽  
Tissue Culture ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
In Vitro Models ◽  
Brain Barrier ◽  
Blood Brain ◽  
Brain Tissue Culture ◽  
The Brain

Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.

Sign in / Sign up

Export Citation Format

Share Document