Cellulosic Nanowhiskers: Preparation and Drug Delivery Applications

Current Drug Delivery ◽

10.2174/1567201818666210525154345 ◽

2021 ◽

Vol 18 ◽

Author(s):

Harmeet Singh ◽

Vineet Kumar

Keyword(s):

Drug Delivery ◽

Cost Effective ◽

Dna Delivery ◽

Viral Gene ◽

Biological Applications ◽

Cellulose Nanowhiskers ◽

Cellulose Nanomaterials ◽

Viral Gene Delivery ◽

Hydrolysis Of ◽

Plant Sources

: Nanomaterials have applications in almost every field and among them, green nanomaterials have various biological applications. Green nanomaterials are specifically useful for drug and DNA delivery applications. Considering that cellulose is the most abundant and easily available biomolecules, and it has been used for preparing greener cellulose nanomaterials. Cellulosic nanowhiskers are a cost-effective and green alternative to chemical non-viral gene delivery systems. Cellulose nanowhiskers are commonly extracted from plant sources, and they are generally prepared by sulfuric and hydrochloric acid hydrolysis of plant cellulose. In this review, the topic of cellulose nanowhiskers as green biocompatible materials for gene and drug delivery is discussed with several practical examples.

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Chitosan nanoparticles: process and their application as drug delivery.

SQUALEN Bulletin of Marine and Fisheries Postharvest and Biotechnology ◽

10.15578/squalen.v6i1.55 ◽

2010 ◽

Vol 6 (1) ◽

pp. 1

Author(s):

Hari Eko Irianto ◽

Ijah Muljanah

Keyword(s):

Drug Delivery ◽

Polyelectrolyte Complex ◽

Chitosan Nanoparticles ◽

Cross Linking ◽

Viral Gene ◽

Ionic Gelation ◽

Emulsion Droplet ◽

Gene Delivery Vectors ◽

Potential Applications ◽

Viral Gene Delivery

Chitosan has wide ranges of potential applications and Indonesia possesses abundant rawmaterial sources such as crab and shrimp shells to produce it. Chitosan have beneficial properties,i.e. biocompatible, biodegradable, non-toxic and inexpensive. Nowadays, several experimentson the preparation of chitosan into nanoparticles and its utilization as drug delivery for varioustargeted therapies have been conducted. Chitosan nanoparticles can be prepared using variousmethods, e.g. emulsion cross-linking, precipitation, spray drying, emulsion-droplet coalescencemethod, ionic gelation, reverse micellar method and polyelectrolyte complex. Applications ofchitosan nanoparticles as drug delivery can be performed through diverse administrations includingparenteral, peroral and ocular, non-viral gene delivery vectors, vaccine delivery, and photodynamictherapy.

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A small, bifunctional synthetic peptide for non-viral gene delivery to hepatocytes via the serpin-enzyme complex receptor

Journal of Hepatology ◽

10.1016/s0168-8278(01)80322-6 ◽

2001 ◽

Vol 34 (0) ◽

pp. 91

Author(s):

S Patel

Keyword(s):

Gene Delivery ◽

Synthetic Peptide ◽

Viral Gene ◽

Enzyme Complex ◽

Complex Receptor ◽

Viral Gene Delivery

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Faculty Opinions recommendation of Actin cytoskeleton as the principal determinant of size-dependent DNA mobility in cytoplasm: a new barrier for non-viral gene delivery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023279.270637 ◽

2005 ◽

Author(s):

Yu-Li Wang

Keyword(s):

Gene Delivery ◽

Actin Cytoskeleton ◽

Viral Gene ◽

Size Dependent ◽

Dna Mobility ◽

Viral Gene Delivery

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Recent advances in the analysis full/empty capsid ratio and genome integrity of adeno-associated virus (AAV) gene delivery vectors

Current Molecular Medicine ◽

10.2174/1566524020999200730181042 ◽

2020 ◽

Vol 20 ◽

Author(s):

L. Hajba ◽

A. Guttman

Keyword(s):

Gene Delivery ◽

High Efficiency ◽

Analytical Techniques ◽

Viral Gene ◽

Adeno Associated Virus ◽

Gene Delivery Vectors ◽

Empty Capsid ◽

Purification Methods ◽

Viral Gene Delivery

: Adeno-associated virus (AAV) is one of the most promising viral gene delivery vectors with long-term gene expression and disease correction featuring high efficiency and excellent safety in human clinical trials. During the production of AAV vectors,there are several quality control (QC)parameters that should be rigorously monitored to comply with clini-cal safety and efficacy. This review gives a short summary of the most frequently used AVV production and purification methods,focusing on the analytical techniques applied to determine the full/empty capsid ratio and the integrity of the encapsidated therapeutic DNA of the products.

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