Effects of Early Maternal Separation on Biobehavioral and Neuropathological Markers of Alzheimer's Disease in Adult Male Rats

2013 ◽  
Vol 10 (4) ◽  
pp. 420-432 ◽  
Author(s):  
Eva Martisova ◽  
Barbara Aisa ◽  
Gorka Guerenu ◽  
Maria Javier Ramirez
Keyword(s):  
Adult Male ◽  
Maternal Separation ◽  
Male Rats

Influence of juvenile housing conditions on the ventilatory, thermoregulatory, and endocrine responses to hypoxia of adult male rats

2011 ◽  
Vol 111 (2) ◽  
pp. 516-523 ◽  
Author(s):  
Sébastien Fournier ◽  
Vincent Joseph ◽  
Richard Kinkead
Keyword(s):  
Adult Male ◽  
Maternal Separation ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Male Rats ◽  
Whole Body ◽  
Housing Conditions ◽  
Juvenile Period ◽  
Hypoxic Conditions ◽  
Respiratory Plasticity

“Extreme” housing conditions, such as isolation (single housing) or crowding, are stressful for rats, and their deleterious impact on behavior is well documented. To determine whether more subtle variations in housing can affect animal physiology, the present study tested the hypothesis that the hypoxic ventilatory response (HVR) of adult male rats housed in pairs during the juvenile period (postnatal day 21 to adulthood) does not differ from that of animals housed in triads. Because neonatal stress augments the neuroendocrine responsiveness to stress and HVR, experiments were performed both on “control” (undisturbed) animals and rats subjected to neonatal maternal separation (NMS; 3 h/day, postnatal days 3–12). At adulthood, ventilatory activity was measured by whole body plethysmography under normoxic and hypoxic conditions (inspired fraction of O2 = 0.12; 20 min). The ventilatory and body temperature responses to hypoxia of rats raised in triads were less than those of rats housed in pairs. For the HVR, however, the attenuation induced by triad housing was more important in NMS rats. Triad housing decreased “basal” plasma corticosterone, but increased estradiol and testosterone levels. Much like the HVR, housing-related decrease in corticosterone level was greater in NMS than control rats. We conclude that modest changes in housing conditions (pairs vs. triads) during the juvenile period can influence basic homeostatic functions, such as temperature, endocrine, and respiratory regulation. Housing conditions can influence (even eliminate) the manifestations of respiratory plasticity subsequent to deleterious neonatal treatments. Differences in neuroendocrine function likely contribute to these effects.

Low doses of prenatal ethanol exposure and maternal separation alter HPA axis function and ethanol consumption in adult male rats

2018 ◽  
Vol 131 ◽  
pp. 271-281 ◽  
Author(s):  
F. Biggio ◽  
G. Talani ◽  
V. Locci ◽  
M.G. Pisu ◽  
G. Boero ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Adult Male ◽  
Maternal Separation ◽  
Ethanol Consumption ◽  
Ethanol Exposure ◽  
Male Rats ◽  
Low Doses ◽  
Prenatal Ethanol Exposure

Neonatal stress and attenuation of the hypercapnic ventilatory response in adult male rats: the role of carotid chemoreceptors and baroreceptors

2010 ◽  
Vol 299 (5) ◽  
pp. R1279-R1289 ◽  
Author(s):  
Frédéric S. Dumont ◽  
Richard Kinkead
Keyword(s):  
Adult Male ◽  
Maternal Separation ◽  
Ventilatory Response ◽  
Respiratory Control ◽  
Pressure Change ◽  
Male Rats ◽  
Arterial Blood ◽  
Carotid Bodies ◽  
Neonatal Maternal Separation ◽  
Underlying Mechanisms

Neonatal maternal separation (NMS) is a form of stress that disrupts respiratory control development. Awake adult male rats previously subjected to NMS show a ventilatory response to hypercapnia (HCVR; FiCO2 = 0.05) 47% lower than controls; however, the underlying mechanisms are unknown. To address this issue, we first tested the hypothesis that carotid bodies contribute to NMS-related attenuation of the HCVR by using carotid sinus nerve section or FiO2 manipulation to maintain PaO2 constant (iso-oxic) during hypercapnic hyperpnea. We then determined whether NMS-related augmentation of baroreflex sensitivity contributes to the reduced HCVR in NMS rats. Nitroprusside and phenylephrine injections were used to manipulate arterial blood pressure in both groups of rats. Pups subjected to NMS were separated from their mother 3 h/day from postnatal days 3 to 12. Control rats were undisturbed. At adulthood, rats were anesthetized [urethane (1g/kg) + isoflurane (0.5%)], and diaphragmatic electromyogram (dEMG) was measured under baseline and hypercapnic conditions (PaCO2: 10 Torr above baseline). The relative minute activity response to hypercapnia of anesthetized NMS rats was 34% lower than controls. Maintaining PaO2 constant during hypercapnia reversed this phenotype; the HCVR of NMS rats was 45% greater than controls. Although the decrease in breathing frequency during baroreflex activation was greater in NMS rats, the change observed within the range of pressure change observed during hypercapnia was minimal. We conclude that NMS-related changes in carotid body sensitivity to chemical stimuli and/or its central integration is a key mechanism in the attenuation of HCVR by NMS.

Prenatal immobilization stress and postnatal maternal separation cause differential neuroendocrine responses to fasting stress in adult male rats

2019 ◽  
Vol 62 (6) ◽  
pp. 737-748 ◽  
Author(s):  
Angélica Roque ◽  
Roberto Ruiz‐González ◽  
Edel Pineda-López ◽  
Luz Torner ◽  
Naima Lajud
Keyword(s):  
Adult Male ◽  
Maternal Separation ◽  
Immobilization Stress ◽  
Male Rats ◽  
Neuroendocrine Responses

Early maternal separation has mild effects on cardiac autonomic balance and heart structure in adult male rats

Stress ◽  
2011 ◽  
Vol 15 (4) ◽  
pp. 457-470 ◽  
Author(s):  
M. Trombini ◽  
H. J. Hulshof ◽  
G. Graiani ◽  
L. Carnevali ◽  
P. Meerlo ◽  
...  
Keyword(s):  
Adult Male ◽  
Maternal Separation ◽  
Male Rats ◽  
Autonomic Balance

Voluntary Exercise During Adolescence Mitigated Negative the Effects of Maternal Separation Stress on the Depressive-Like Behaviors of Adult Male Rats: Role of NMDA Receptors

2018 ◽  
Vol 43 (5) ◽  
pp. 1067-1074 ◽  
Author(s):  
Forouzan Fattahi Masrour ◽  
Maghsoud Peeri ◽  
Mohammad Ali Azarbayjani ◽  
Mir-Jamal Hosseini
Keyword(s):  
Nmda Receptors ◽  
Adult Male ◽  
Maternal Separation ◽  
Voluntary Exercise ◽  
Male Rats

scholarly journals Correction: Maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0210893
Author(s):  
Soheila Maghami ◽  
Homeira Zardooz ◽  
Fariba Khodagholi ◽  
Fatemeh Binayi ◽  
Roya Ranjbar Saber ◽  
...  
Keyword(s):  
Young Adult ◽  
Spatial Memory ◽  
Adult Male ◽  
Maternal Separation ◽  
Memory Formation ◽  
Male Rats ◽  
Insulin Content ◽  
Young Adult Male
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