Voluntary Exercise During Adolescence Mitigated Negative the Effects of Maternal Separation Stress on the Depressive-Like Behaviors of Adult Male Rats: Role of NMDA Receptors

2018 ◽  
Vol 43 (5) ◽  
pp. 1067-1074 ◽  
Author(s):  
Forouzan Fattahi Masrour ◽  
Maghsoud Peeri ◽  
Mohammad Ali Azarbayjani ◽  
Mir-Jamal Hosseini
Keyword(s):  
Nmda Receptors ◽  
Adult Male ◽  
Maternal Separation ◽  
Voluntary Exercise ◽  
Male Rats

Effects of Early Maternal Separation on Biobehavioral and Neuropathological Markers of Alzheimer's Disease in Adult Male Rats

2013 ◽  
Vol 10 (4) ◽  
pp. 420-432 ◽  
Author(s):  
Eva Martisova ◽  
Barbara Aisa ◽  
Gorka Guerenu ◽  
Maria Javier Ramirez
Keyword(s):  
Adult Male ◽  
Maternal Separation ◽  
Male Rats

On the role of corticosterone in behavioral disorders, microbiota composition alteration and neuroimmune response in adult male mice subjected to maternal separation stress

2019 ◽  
Vol 66 ◽  
pp. 242-250 ◽  
Author(s):  
Hossein Amini-Khoei ◽  
Elaheh Haghani-Samani ◽  
Masoumeh Beigi ◽  
Amin Soltani ◽  
Gholam Reza Mobini ◽  
...  
Keyword(s):  
Behavioral Disorders ◽  
Adult Male ◽  
Maternal Separation ◽  
Microbiota Composition ◽  
Male Mice

scholarly journals AMELIORATIVE ROLE OF BONE MARROW MESENCHYMAL STEM CELLS AND RUTIN AGAINST ACETAMINOPHEN INDUCED HEPATOTOXICITY IN ADULT MALE RATS.

2017 ◽  
Vol 5 (9) ◽  
pp. 450-459
Author(s):  
WalaaAMEl Nahrawy ◽  
◽  
FatmaAAbu Zahra ◽  
RabhaEAEL Dab ◽  
◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adult Male ◽  
Male Rats ◽  
Marrow Mesenchymal Stem Cells

scholarly journals The Effect of Induced Diabetes Mellitus on the Cerebellar Cortex of Adult Male Rat and the Possible Protective Role of Oxymatrine: A Histological, Immunohistochemical and Biochemical Study

2021 ◽  
Author(s):  
Amany Mohamed Shalaby ◽  
Adel Mohamed Aboregela ◽  
Mohamed Ali Alabiad ◽  
Mona Tayssir Sadek
Keyword(s):  
Diabetes Mellitus ◽  
Purkinje Cells ◽  
Cerebellar Cortex ◽  
Adult Male ◽  
Protective Role ◽  
Diabetic Rats ◽  
Male Rats ◽  
Group I ◽  
Group Ii

Abstract Diabetes mellitus (DM) represents a widespread metabolic disease with a well-known neurotoxicity in both central and peripheral nervous systems. Oxymatrine is a traditional Chinese herbal medicine that has various pharmacological activities including; anti-oxidant, anti-apoptotic and anti-inflammatory potentials. The present work aimed to study the impact of diabetes mellitus on the cerebellar cortex of adult male albino rat and to evaluate the potential protective role of oxymatrine using different histological methods. Fifty-five adult male rats were randomly divided into three groups: group I served as control, group II was given oxymatrine (80 mg/kg/day) orally for 8 weeks and group III was given a single dose of streptozotocin (50mg/kg) intaperitoneally to induce diabetes. Then diabetic rats were subdivided into two subgroups: subgroup IIIa that received no additional treatment and subgroup IIIb that received oxymatrine similar to group II. The diabetic group revealed numerous changes in the Purkinje cell layer in the form of multilayer arrangement of Purkinje cells, shrunken cells with deeply stained nuclei as well as focal loss of the Purkinje cells. A significant increment in GFAP and synaptophysin expression was reported. Transmission electron microscopy showed irregularity and splitting of myelin sheaths in the molecular layer, dark shrunken Purkinje cells with ill-defined nuclei, dilated Golgi saccules and dense granule cells with irregular nuclear outlines in the granular layer. In contrast, these changes were less evident in diabetic rats that received oxymatrine. In conclusion, Oxymatrine could protect the cerebellar cortex against changes induced by DM.

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