Mild Cognitive Impairment: Advantages of a Comprehensive Neuropsychological Assessment

2013 ◽  
Vol 10 (10) ◽  
pp. 1098-1106 ◽  
Author(s):  
E.I. Drexler ◽  
B. Voss ◽  
K. Amunts ◽  
F. Schneider ◽  
U. Habel
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Neuropsychological Assessment

scholarly journals Korean Traditional Medicine in Treating Patients with Mild Cognitive Impairment: A Multicenter Prospective Observational Case Series

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Yujin Choi ◽  
Young-Eun Kim ◽  
Ui Min Jerng ◽  
Hwan Kim ◽  
Sung Ik Lee ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Herbal Medicine ◽  
Neuropsychological Assessment ◽  
Clinical Setting ◽  
Case Series ◽  
Cognitive Disorders ◽  
Mean Difference ◽  
Korean Medicine ◽  
The Real

In Korea, patients with mild cognitive impairment can choose to receive treatment of Korean medicine, and Korean medicine hospitals provide specialized medical care for the prevention and management of cognitive disorders. The aim of the study is to explore the role of Korean medicine therapy for patients with mild cognitive impairment in a real clinical setting. Fifteen patients with amnestic mild cognitive impairment were enrolled in this prospective observational study in three Korean medicine hospitals. Korean medicine treatments were delivered by experienced professionals and not restricted to standardized treatment. Outcome measures were prospectively planned to examine the Korean-Montreal Cognitive Assessment (K-MoCA), Korean-Mini Mental State Examination (K-MMSE), and other detailed neuropsychological assessment at the baseline and after 12 and 24 weeks of treatment. Korean medicine treatment for MCI treatment in the real-world clinical setting included herbal medicine and acupuncture. The most frequently used herbs in herbal decoctions were Acori Graminei Rhizoma, Polygalae Radix, and Poria Sclerotium Cum Pini Radix. The herbal medicine formulae used in this study were classified into three categories: tonifying Qi (33.3%), tonifying kidney (46.7%), and calming liver (20%) formulae. In the cognitive ability assessment, the K-MoCA score significantly improved after treatment (mean difference 2.6; 95% CI: 1.3 to 3.9, p=0.001). The K-MMSE score slightly increased after treatment; however, the improvement was not statistically significant (mean difference 0.8; 95% CI: −0.5 to 2.0, p=0.195). In detailed neuropsychological assessment, the cognitive domains of executive functions and memory after the treatment were distinctively improved. In this prospective observational case series, we could see the real clinical environments of treating patients with mild cognitive impairment in Korean medicine hospitals. Patients treated with Korean medicine showed improved results in the neuropsychological assessment after 12 and 24 weeks.

scholarly journals Predicting outcome in mild cognitive impairment: 4-year follow-up study

2010 ◽  
Vol 197 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Jane A. Lonie ◽  
Mario A. Parra-Rodriguez ◽  
Kevin M. Tierney ◽  
Lucie L. Herrmann ◽  
Claire Donaghey ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Neuropsychological Assessment ◽  
Verbal Learning ◽  
Cognitive Screening ◽  
Prognostic Information ◽  
Predictive Values ◽  
Diagnosis And Prognosis ◽  
Demographic Indices ◽  
Sensitivity Specificity

BackgroundCognitive impairment precedes the diagnosis of Alzheimer's disease. It is unclear which psychometric measures predict dementia, and what cut-off points should be used. Replicable cognitive measures to provide information about differential diagnosis and prognosis would be clinically useful.AimsIn a prospective cohort study we investigated which measures distinguish between individuals with amnestic mild cognitive impairment (aMCI) that converts to dementia and those whose impairment does not, and which combination of measures best predicts the fate of people with aMCI.MethodForty-four participants with aMCI underwent extensive neuropsychological assessment at baseline and annually thereafter for an average of 4 years. Differences in baseline cognitive performance of participants who were converters and non-converters to clinically diagnosed dementia were analysed. Classification accuracy was estimated by sensitivity, specificity, positive and negative predictive values and using logistic regression.ResultsForty-one percent of participants had progressed to dementia by the end of study, with a mean annual conversion rate of 11%. Most (63%) showed persisting or progressive cognitive impairment, irrespective of diagnosis. The Addenbrooke's Cognitive Examination together with the discrimination index of the Hopkins Verbal Learning Test – Revised (but none of the demographic indices) differentiated the participants who were converters from the non-converters at baseline with 74% accuracy.ConclusionsTargeted neuropsychological assessment, beyond simple cognitive screening, could be used in clinical practice to provide individuals with aMCI with prognostic information and aid selective early initiation of monitoring and treatment among those who progress towards a clinically diagnosable dementia.

Preliminary Validation of the Global Neuropsychological Assessment in Alzheimer’s Disease and Healthy Volunteers

Assessment ◽  
2021 ◽  
pp. 107319112199122
Author(s):  
Lauren T. Olson ◽  
Alan Smerbeck ◽  
Christina M. Figueroa ◽  
Jeremy M. Raines ◽  
Kinga Szigeti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Neuropsychological Assessment ◽  
Performance Test ◽  
Digit Span ◽  
Intraclass Correlation ◽  
Healthy Controls ◽  
Adult Intelligence Scale

Methods We administered the Global Neuropsychological Assessment (GNA), an abbreviated cognitive battery, to 105 adults aged 73.0 ± 7.1 years, including 28 with probable Alzheimer’s disease, 9 with amnestic mild cognitive impairment, and 68 healthy controls. We examined group differences in baseline performance, test–retest reliability, and correlations with other conventional tests. Results Healthy adults outperformed patients on all five GNA subtests. Test–retest intraclass correlation coefficients were significant for all GNA subtests. Among patients with healthy controls, GNA Story Memory correlated best with Wechsler Memory Scale–Revised (WMS-R) Logical Memory for learning and delayed recall, GNA Digit Span correlated most highly with the Wechsler Adult Intelligence Scale–Third Edition (WAIS-III) Digit Span, GNA Perceptual Comparison correlated most highly with the Trail Making Test, and GNA Animal Naming correlated most highly with Supermarket Item Naming. Conclusions Preliminary findings suggest that the GNA shows good test–retest validity, clear convergent and discriminant construct validity, and excellent diagnostic criterion validity for dementia and mild cognitive impairment in an American sample.

Sign in / Sign up

Export Citation Format

Share Document