Early, Intensive and Long-term Statin Therapy in Acute Coronary Syndrome: Focus on Anti-inflammatory Mechanisms

2005 ◽  
Vol 2 (3) ◽  
pp. 181-186 ◽  
Author(s):  
Jian-Jun Li ◽  
Sheng-Shou Hu
Keyword(s):  
Acute Coronary Syndrome ◽  
Statin Therapy ◽  
Coronary Syndrome ◽  
Anti Inflammatory

scholarly journals Long-Term Efficacy Of Lower Intensity Statin Therapy In Chinese Acute Coronary Syndrome Patients

2018 ◽  
Vol 21 ◽  
pp. S26
Author(s):  
BP Yan ◽  
CK Chan ◽  
MC Wong ◽  
OT To ◽  
VW Lee
Keyword(s):  
Acute Coronary Syndrome ◽  
Statin Therapy ◽  
Lower Intensity ◽  
Coronary Syndrome ◽  
Term Efficacy

scholarly journals Low-density lipoprotein cholesterol levels on admission and long-term outcomes in statin-naive patients with acute coronary syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R Satou ◽  
Y Matsuzawa ◽  
E Akiyama ◽  
M Konishi ◽  
T Yoshii ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Statin Therapy ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Coronary Syndrome ◽  
Composite Outcomes

Abstract Introduction Dyslipidemia, especially an increase in the low-density lipoprotein cholesterol (LDL-C) has been established as one of the most important risk factors for atherosclerotic cardiovascular diseases. In contrast, some recent studies have shown that the low LDL-C level was associated with short-term poor prognosis in patients with cardiovascular disease, and this is so-called “cholesterol paradox”. However, there is few data evaluating the effects on long-term outcome of “cholesterol paradox” in patients with acute coronary syndrome (ACS). Purpose The purpose of this study was to examine whether the low LDL-C level on admission affect long-term prognosis in patients with ACS. Methods A total of 434 ACS patients who survived to hospital discharge were enrolled in this study. All patients were statin-naïve on admission, and were received statin therapy after hospitalization. Patients were divided into the low LDL-C (≤114 mg/dl) and high LDL-C (>114 mg/dl) groups using the first tertile of the LDL-C level on admission. The primary endpoint was composite outcomes of all-cause death, myocardial infarction, ischemic stroke, hospitalization for congestive heart failure and unplanned revascularization. Results During a median follow-up period of 5.5 years, primary endpoint occurred in 117 patients. Overall, event-free rates differed significantly between the low and high LDL-C groups, demonstrating the lower event-free rate in patients with the low LDL-C group (38.9% in low LDL-C group versus 20.7% in high LDL-C group, p=0.0002; Figure). Even after adjustment for age, sex, body mass index, and various classical risk factors, the low LDL-C group was significantly at higher risk for primary composite outcomes compared to the high LDL-C group (adjusted hazard ratio 1.65, 95%-confidence interval 1.10–2.49, p=0.02). Conclusion In patients with ACS, the low LDL-C level on admission was significantly associated with long-term worse prognosis, regardless of statin therapy at discharge. In ACS patients with low LDL-C level, it might be necessary for elucidating the residual risk for secondary adverse event to improve their prognosis. Funding Acknowledgement Type of funding source: None

Long-Term Benefit of Statin Therapy Initiated??during Hospitalization for??an??Acute??Coronary Syndrome

2007 ◽  
Vol 7 (2) ◽  
pp. 135-141 ◽  
Author(s):  
Anthony A Bavry ◽  
Girish R Mood ◽  
Dharam J Kumbhani ◽  
Peter P Borek ◽  
Arman T Askari ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Statin Therapy ◽  
Coronary Syndrome ◽  
Term Benefit

scholarly journals Impact of Statin Therapy on Renal Function and Long-Term Prognosis in Acute Coronary Syndrome Patients With Chronic Kidney Disease

2010 ◽  
Vol 51 (5) ◽  
pp. 312-318 ◽  
Author(s):  
Toshiyuki Shibui ◽  
Akihiro Nakagomi ◽  
Yoshiki Kusama ◽  
Hirotsugu Atarashi ◽  
Kyoichi Mizuno
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Coronary Syndrome ◽  
Renal Function ◽  
Kidney Disease ◽  
Statin Therapy ◽  
Coronary Syndrome ◽  
Long Term Prognosis

scholarly journals Antiatherosclerotic Effects of Long-Term Maximally Intensive Statin Therapy After Acute Coronary Syndrome

2014 ◽  
Vol 34 (11) ◽  
pp. 2465-2472 ◽  
Author(s):  
Rishi Puri ◽  
Steven E. Nissen ◽  
Mingyuan Shao ◽  
Christie M. Ballantyne ◽  
Philip J. Barter ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Statin Therapy ◽  
Coronary Syndrome ◽  
Intensive Statin Therapy
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