Abstract:
A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic moiety 5-pyrazolone
is well known five membered ring containing nitrogen. Derivatives of this wonder nucleus have exhibited activities as
diverse as antimicrobial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic,
antiviral, antitubercular, antioxidant, anticancer and antiviral including action against severe acute respiratory syndrome
(SARS) or 3C protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard texts
and literature on medicinal chemistry cite different approaches for the synthesis of 5-pyrazolones. The present review
provides an insight view to 5-pyrazolone synthesis, their biological profile and structure activity relationship studies.