Eudragit, a Nifty Polymer for Anticancer Preparations: A Patent Review

2021 ◽  
Vol 16 ◽  
Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve
Keyword(s):  
Drug Delivery ◽  
Methacrylic Acid ◽  
Drug Delivery Systems ◽  
Pharmaceutical Formulations ◽  
Delivery Systems ◽  
Ionic Polymers ◽  
Site Specific ◽  
Patent Review ◽  
The Matrix ◽  
Prevention Of Cancer

Background: Polymers are the backbone of modern pharmaceutical formulations and drug delivery technologies. Polymers that may be natural, synthetic, or semisynthetic are used to control the release of drugs in a pre-programmed fashion. The drug delivery systems are mainly prepared to enhance the bioavailability, site-specific release, sustained release, controlled release, i.e., to modify the release of drug from dosage form may be a tablet, capsule, etc. Objective: The objective of the present study is to overview the recent patents concerning the application of eudragit in the prevention of cancer and other ailments. Eudragit polymers are polymethacrylates and may be anionic, cationic, or non-ionic polymers of methacrylic acid, dimethyl-aminoethyl methacrylates, and methacrylic acid esters in varying ratios. Eudragit is available in various grades with solubilities at different pH, thus helping the formulators design the preparation to have a well-defined release pattern. Method: In this review, patent applications of eudragit in various drug delivery systems employed to cure mainly cancer are covered. Results : Eudragit has proved its potential as a polymer to control the release of drugs as coating polymer and formation of the matrix in various delivery systems. It can increase the bioavailability of the drug by site-specific drug delivery and can reduce the side effects/toxicity associated with anticancer drugs. Conclusion: The potential of eudragit to carry the drug may unclutter novel ways for therapeutic intercessions in various tumors.

Site Specific Chronotherapeutic Drug Delivery Systems: A Patent Review

2009 ◽  
Vol 3 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Nitin Saigal ◽  
Sanjula Baboota ◽  
Alka Ahuja ◽  
Javed Ali
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Site Specific ◽  
Patent Review

Chitosan- A Potential Polymer to Prepare Anticancer Drug Delivery Systems- Patent Review

2021 ◽  
Vol 16 ◽  
Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Patent Application ◽  
Delivery Systems ◽  
Therapeutic Interventions ◽  
Natural Polymers ◽  
Cellular Functions ◽  
Anticancer Drug Delivery ◽  
Patent Review ◽  
Prevention Of Cancer

Background: Polymers are used in drug delivery systems to encapsulate and release the drug. Natural polymers have the advantages such as biodegradability, biocompatibility, biological recognizable moieties that maintain cellular functions as compared to synthetic polymers. Chitosan is a natural polycationic linear polysaccharide originated from chitin. Its easy modification, release rate of drug, ability to cross link with other polymers, gelling ability, immunostimulation, bioadhesion, biocompatibility and biodegrability has increased its application in various drug delivery systems. Objective: The objective of the present study is to overview the recent patents of application of chitosan in various drug delivery systems and their use in the prevention of cancer and other ailments. Methods: In this review patent application of chitosan in various drug delivery systems employed to cure mainly cancer has been covered with particular emphasis on their scientific impact and novelty. Results: Chitosan has proved its potential as a polymer to control and target the drug at the site of action. Conclusion: The potential of chitosan and its derivatives to deliver and target the drug may open new avenues for therapeutic interventions in different tumors.

Biosurfactants as a Novel Additive in Pharmaceutical Formulations: Current Trends and Future Implications

2020 ◽  
Vol 21 (11) ◽  
pp. 885-901
Author(s):  
Shubham Thakur ◽  
Amrinder Singh ◽  
Ritika Sharma ◽  
Rohan Aurora ◽  
Subheet Kumar Jain
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Toxicity Testing ◽  
Pharmaceutical Formulations ◽  
Delivery Systems ◽  
Surface Active Agents ◽  
Regulatory Status ◽  
Different Temperatures ◽  
High Production Cost ◽  
New Generation

Background: Surfactants are an important category of additives that are used widely in most of the formulations as solubilizers, stabilizers, and emulsifiers. Current drug delivery systems comprise of numerous synthetic surfactants (such as Cremophor EL, polysorbate 80, Transcutol-P), which are associated with several side effects though used in many formulations. Therefore, to attenuate the problems associated with conventional surfactants, a new generation of surface-active agents is obtained from the metabolites of fungi, yeast, and bacteria, which are termed as biosurfactants. Objectives: In this article, we critically analyze the different types of biosurfactants, their origin along with their chemical and physical properties, advantages, drawbacks, regulatory status, and detailed pharmaceutical applications. Methods: 243 papers were reviewed and included in this review. Results: Briefly, Biosurfactants are classified as glycolipids, rhamnolipids, sophorolipids, trehalolipids, surfactin, lipopeptides & lipoproteins, lichenysin, fatty acids, phospholipids, and polymeric biosurfactants. These are amphiphilic biomolecules with lipophilic and hydrophilic ends and are used as drug delivery vehicles (foaming, solubilizer, detergent, and emulsifier) in the pharmaceutical industry. Despite additives, they have some biological activity as well (anti-cancer, anti-viral, anti-microbial, P-gp inhibition, etc.). These biomolecules possess better safety profiles and are biocompatible, biodegradable, and specific at different temperatures. Conclusion: Biosurfactants exhibit good biomedicine and additive properties that can be used in developing novel drug delivery systems. However, more research should be driven due to the lack of comprehensive toxicity testing and high production cost which limits their use.

scholarly journals A bio-orthogonal functionalization strategy for site-specific coupling of antibodies on vesicle surfaces after self-assembly

2020 ◽  
Vol 11 (2) ◽  
pp. 527-540 ◽  
Author(s):  
Meiyu Gai ◽  
Johanna Simon ◽  
Ingo Lieberwirth ◽  
Volker Mailänder ◽  
Svenja Morsbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Site Specific ◽  
Self Assembled

Attaching targeting ligands on the surface of self-assembled drug delivery systems is one of the key requests for a controlled transport of the drug to a desired location.

Taylor dispersion analysis in fused silica capillaries: a tutorial review

2021 ◽  
Author(s):  
Meagan Rhyne Moser ◽  
Christopher Anthony Baker
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Pharmaceutical Formulations ◽  
Taylor Dispersion ◽  
Dispersion Analysis ◽  
Delivery Systems ◽  
Fused Silica ◽  
Biomimetic Models ◽  
Fused Silica Capillaries ◽  
Silica Capillaries

Biological and pharmaceutical analytes like liposomes, therapeutic proteins, nanoparticles, and drug-delivery systems are utilized in applications, such as pharmaceutical formulations or biomimetic models, in which controlling their size is often...

scholarly journals Clay-Based Pharmaceutical Formulations and Drug Delivery Systems

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1142
Author(s):  
Fátima García-Villén ◽  
César Viseras
Keyword(s):  
Drug Delivery ◽  
Health Care ◽  
Drug Delivery Systems ◽  
Pharmaceutical Formulations ◽  
Delivery Systems

The use of minerals as ingredients in health care products is a classical and active pharmaceutical subject [...]

scholarly journals A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 661 ◽  
Author(s):  
Jan Konasch ◽  
Alexander Riess ◽  
Robert Mau ◽  
Michael Teske ◽  
Natalia Rekowska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Additive Manufacturing ◽  
Inkjet Printing ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Blue Dye ◽  
Glycol Diacrylate ◽  
Coomassie Blue ◽  
The Matrix ◽  
Model Drug

Here, we present a new hybrid additive manufacturing (AM) process to create drug delivery systems (DDSs) with selectively incorporated drug depots. The matrix of a DDS was generated by stereolithography (SLA), whereas the drug depots were loaded using inkjet printing. The novel AM process combining SLA with inkjet printing was successfully implemented in an existing SLA test setup. In the first studies, poly(ethylene glycol) diacrylate-based specimens with integrated depots were generated. As test liquids, blue and pink ink solutions were used. Furthermore, bovine serum albumin labeled with Coomassie blue dye as a model drug was successfully placed in a depot inside a DDS. The new hybrid AM process makes it possible to place several drugs independently of each other within the matrix. This allows adjustment of the release profiles of the drugs depending on the size as well as the position of the depots in the DDS.

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