Fluorinated-NHC Transition Metal Complexes Leading Characters as Potential Anticancer Metallodrugs

2020 ◽  
Vol 20 ◽  
Author(s):  
Ernesto Rufino-Felipe ◽  
Raúl Colorado-Peralta ◽  
Viviana Reyes-Márquez ◽  
Hugo Valdés ◽  
David Morales-Morales
Keyword(s):  
Transition Metal ◽  
Cancer Treatment ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Medicinal Chemistry ◽  
Biological Properties ◽  
Anticancer Metallodrugs

: In the last 20 years, N-heterocyclic carbene (NHC) ligands have been ubiquitous in biological and medicinal chemistry. Part of their success lays in the tremendous number of topologies that can be synthesized and thus finely tuned that have been described so far. This being particularly true in the case of those derivatives including fluorine or fluorinated fragments on their NHC moieties, attracting much attention due to their enhanced biological properties and turning them in excellent candidates for the development of novel metallodrugs. Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and their impact in cancer treatment.

Novel Chemotherapeutic Agents - The Contribution of Scorpionates

2020 ◽  
Vol 26 (41) ◽  
pp. 7452-7475 ◽  
Author(s):  
Marta A. Andrade ◽  
Luísa M.D.R.S. Martins
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Anticancer Agents ◽  
Medicinal Chemistry ◽  
Bioinorganic Chemistry ◽  
Chemotherapeutic Agents ◽  
Great Role ◽  
Anticancer Properties ◽  
Scorpionate Ligands

: The development of safe and effective chemotherapeutic agents is one of the uppermost priorities and challenges of medicinal chemistry and new transition metal complexes are being continuously designed and tested as anticancer agents. Scorpionate ligands have played a great role in coordination chemistry, since their discovery by Trofimenko in the late 1960s, with significant contributions in the fields of catalysis and bioinorganic chemistry. Scorpionate metal complexes have also shown interesting anticancer properties, and herein, the most recent (last decade) and relevant scorpionate complexes reported for application in medicinal chemistry as chemotherapeutic agents are reviewed. The current progress on the anticancer properties of transition metal complexes bearing homo- or hetero- scorpionate ligands, derived from bis- or tris-(pyrazol-1-yl)-borate or -methane moieties is highlighted.

Spectral, XRD, SEM and biological properties of new mononuclear Schiff base transition metal complexes

2013 ◽  
Vol 35 ◽  
pp. 104-109 ◽  
Author(s):  
M.I. Khan ◽  
Ayub Khan ◽  
Iqbal Hussain ◽  
Murad Ali Khan ◽  
Saima Gul ◽  
...  
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Biological Properties ◽  
Base Transition

scholarly journals Crystal structure, physicochemical properties, Hirshfeld surface analysis and antibacterial activity assays of transition metal complexes of 6-methoxyquinoline

2018 ◽  
Vol 42 (9) ◽  
pp. 7166-7176 ◽  
Author(s):  
C. Villa-Pérez ◽  
I. C. Ortega ◽  
A. Vélez-Macías ◽  
A. M. Payán ◽  
G. A. Echeverría ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Antibacterial Activity ◽  
Transition Metal ◽  
Physicochemical Properties ◽  
Metal Complexes ◽  
Surface Analysis ◽  
Transition Metal Complexes ◽  
Biological Properties ◽  
Hirshfeld Surface ◽  
Hirshfeld Surface Analysis

Five complexes with 6-methoxyquinoline have been synthesized; their structural, spectroscopic, photophysical and biological properties have been studied.

Mechanochemical changes on cyclometalated Ir(iii) acyclic carbene complexes – design and tuning of luminescent mechanochromic transition metal complexes

2020 ◽  
Vol 7 (3) ◽  
pp. 786-794 ◽  
Author(s):  
Jingqi Han ◽  
Kin-Man Tang ◽  
Shun-Cheung Cheng ◽  
Chi-On Ng ◽  
Yuen-Kiu Chun ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Carbene Complexes ◽  
New Class

A new class of luminescent cyclometalated Ir(iii) complexes with readily tunable mechanochromic properties derived from the mechanically induced trans-to-cis isomerization have been developed.

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