scholarly journals Risk Factors for Primary Open Angle Glaucoma (POAG) Progression: A Study Ruled in Torino

2016 ◽  
Vol 10 (1) ◽  
pp. 129-139 ◽  
Author(s):  
A.G. Actis ◽  
E. Versino ◽  
B. Brogliatti ◽  
T. Rolle
Keyword(s):  
Risk Factors ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Statistical Significance ◽  
Individual Risk ◽  
Mean Deviation ◽  
Automated Perimetry ◽  
Open Angle ◽  
Individual Risk Factors

Purpose: Aim of this retrospective, observational study is to describe features of a population sample, affected by primary open angle glaucoma (POAG) in order to evaluate damage progression on the basis of the emerged individual risk factors. Methods: We included 190 caucasian patients (377 eyes), evaluating relationship between individual risk factors (explicative variables) and MD (Mean Deviation) of standard automated perimetry. We also considered the dependent variable NFI (Neural Fiber Index) of GDx scanning laser polarimetry. Progression has been evaluated through a statistic General Linear Model on four follow up steps (mean follow up 79 months). Results: Factors reaching statistical significance, determining a worsening of the MD variable, are: age (P<0.0001), intraocular pressure (IOP) at follow up (P < 0.0001), female gender (P<0.0001), hypertension (P< 0.0001) and familiarity (P = 0.0006). Factors reaching statistical significance, determining a worsening of the NFI variable, are only IOP at follow up (P = 0.0159) and depression (P = 0.0104). Conclusion: Results of this study confirm and enforce data coming from most recent studies: IOP remains the main risk factor for glaucoma assess and progression; age and familiarity are great risk factors as underlined in the last decades; female sex can be an important risk factors as emerged only in the last years; arterial hypertension should always be evaluated in timing of our clinic follow up.

scholarly journals Comparing the efficacy of trabeculectomy and XEN gel microstent implantation for the treatment of primary open-angle glaucoma: a retrospective monocentric comparative cohort study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Theresa Theilig ◽  
Matus Rehak ◽  
Catharina Busch ◽  
Caroline Bormann ◽  
Marc Schargus ◽  
...  
Keyword(s):  
Visual Field ◽  
Open Angle Glaucoma ◽  
Statistical Significance ◽  
Field Testing ◽  
Automated Perimetry ◽  
Open Angle ◽  
Comparable Group ◽  
Comparative Cohort Study ◽  
Visual Field Indices

Abstract The aim of this study was to compare the efficacy and safety profile of XEN microstent implantation with trabeculectomy (TET) in a comparable group of open-angle glaucoma cases in a retrospective, monocentric, single-surgeon setting. Each treatment group consisted of 100 eyes of 100 patients. At regular follow-up visits during the first 12 months after surgery, the following assessments were conducted and compared: intraocular pressure (IOP), number of IOP-lowering medications applied, best-corrected visual acuity (BCVA) and visual field testing. In both groups mean IOP was significantly reduced (p < 0.001). Mean IOP dropped from 24.8 ± 7.8 to 14.8 ± 4.0 mmHg in the TET and from 24.5 ± 6.7 to 16.6 ± 4.8 mmHg in the XEN group. The number of active compounds in the prescribed medication dropped from 3.3 ± 1.2 to 1.3 ± 1.4 in the TET and from 3.0 ± 1.1 to 1.4 ± 1.5 in the XEN group. BCVA and mean defect of static automated perimetry did not show a change of statistical significance in either group. Complications were more frequent after TET (p = 0.005) while postoperative needling was more frequent in the XEN group (p = 0.021). TET and XEN led to a significant reduction of IOP and IOP-lowering medication, while BCVA and visual field indices remained mostly unaltered over a 12-month postsurgical follow-up.

scholarly journals 5-year outcomes of single iStent (G1) trabecular microbypass implantation with phacoemulsification in moderately advanced primary open angle glaucoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257015
Author(s):  
Ejaz Ansari
Keyword(s):  
Visual Field ◽  
Outcome Measures ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Case Series ◽  
Secondary Outcome ◽  
Mean Deviation ◽  
Open Angle ◽  
Severe Stage

Purpose To evaluate the safety and efficacy of combined phacoemulsification and single iStent (G1) (iStent, Glaukos Corp. San Clemente, USA), implantation in moderately advanced primary open angle glaucoma (POAG) with 5-years follow-up. Methods Retrospective, interventional case series. All subjects had POAG and underwent single iStent implantation+ phaco+IOL by a single surgeon, with 5 years follow-up. Primary outcome measures: reduction in intraocular pressure (IOP) and proportion of eyes achieving at least 20% reduction of IOP at 5 years. Secondary outcome measures: number of glaucoma drops at 1 through to 5 years; change in visual field mean deviation (MD) at year 5 compared to baseline. Results 35 eyes of 26 patients were included. Mean (sd) medicated pre-op IOP was 18.5 (3.2) mm Hg on mean (sd) 2.3 (1.0) medications. Mean IOP was reduced to 15.9 (4.5) mm Hg on 2.2 (0.9) drops, 15.0mm (4.5) mm Hg on 2.3 (0.9) drops, 15.6 (3.6) mm Hg on 2.5 (1.0) drops, 15.7 (4.43) mmHg on 2.6 (1.0) drops and 14.7 (3.02) mmHg (P<0.001) on 2.7 (1.14) drops (P = 0.06) from 1 through to 5 years. At year 5, 62% of eyes had achieved at least 20% reduction in IOP. MD reduced from -8 (8.1) dB to -10.7 (13.4) dB over 5 years (p = 0.8) at 0.54dB/ annum. One eye required filtering surgery. There were no sight-threatening complications. Conclusion This study showed sustained IOP reduction and excellent safety profile for single iStent implantation. Uniquely it provides data for a more severe stage of glaucoma, and also visual field data, which indicated no significant change through 5 years.

scholarly journals Clinico-Social Profile of Patients Presenting with Primary Open Angle Glaucoma – A Retrospective Study from Paschim Midnapore, West Bengal

2021 ◽  
Vol 8 (22) ◽  
pp. 1792-1796
Author(s):  
Sanjib Kumar Purkait ◽  
Avik Dey Sarkar ◽  
Anil Kumar Ghanta ◽  
Sanchari Sarkar
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Positive Family History ◽  
Visual Fields ◽  
Anterior Segment ◽  
Educational Status ◽  
Automated Perimetry ◽  
Open Angle

BACKGROUND Glaucoma is the second most leading cause of visual loss in the world. Different socio epidemiological parameters like gender, age, socio-economic status, educational status etc. has been directly linked to occurrence of glaucoma in previous studies. Review of the western literature showed that the risk factors associated with glaucoma were high intra ocular pressure (IOP), low blood pressure, low ocular perfusion pressure, narrow anterior chamber angles, thin corneas, pseudoexfoliation, a low body mass index (BMI), and myopia. We need to evaluate the clinical and epidemiological factors affecting primary open angle glaucoma. METHODS Records of patients with a diagnosis of primary open-angle glaucoma (POAG) were studied. All data, addressing demographics (gender, age and skin colour), socioeconomic status, educational status, emotional status and clinical information concerning risk factors for developing glaucoma (family history of glaucoma, hypertension and diabetes mellitus) and any treatment history (e.g., corticosteroid intake) were noted. Findings from visual acuity examination, refraction, detailed anterior segment examination by slit lamp, fundus examination with 90 D, gonioscopy, applanation tonometry, VF examination by automated perimetry and A-scan USG were also carefully taken into account. RESULTS A total 920 patients were enrolled of which 67.94 % were males and 57.6 % were from urban population. 18.7 % cases had positive family history. Most of the patients came from lower and middle-income group (43.48 % and 48.37 % respectively). Cup-disc ratio of majority of eyes was found to be more than 0.30 (97.29 %). Different grades of disc changes and field changes were noted. Cupdisc ratio asymmetry of more than 0.20 was found in 355 (38.59 %) eyes. Paracentral and / or arcuate scotoma was detected in 585 eyes (31.80 %). CONCLUSIONS Understanding the socio-demography and socio-economy helps in early diagnosis and better assessment of the disease severity in POAG. KEYWORDS Glaucoma, POAG, CDR, Visual Fields

Topical Bimatoprost Insert for Primary Open-Angle Glaucoma and Ocular Hypertension Treatment - A Phase II Controlled Study

2021 ◽  
Vol 18 ◽  
Author(s):  
Francine Rubião ◽  
Alan Cezar Faria Araújo ◽  
João Bernardo Sancio ◽  
Bárbara Silva Nogueira ◽  
Juçara Ribeiro Franca ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
T Test ◽  
Controlled Study ◽  
Therapeutic Drug ◽  
Eye Drops ◽  
Open Angle ◽  
Drug Concentrations

Background: The most common treatment for primary open-angle glaucoma (POAG) is the daily use of eye drops. Sustained-release drug delivery systems have been developed to improve patient adherence by achieving prolonged therapeutic drug concentrations in ocular target tissues while limiting systemic exposure. The purpose of this study is to compare the efficacy and safety of bimatoprost inserts with bimatoprost eye drops in patients with POAG and ocular hypertension (OH). Methods: We include OH and POAG patients aged between 40 and 75 years-old. Both OH and POAG patients had intraocular pressure (IOP) greater than 21 and ≤30 mmHg at 9:00 am without glaucoma medication and normal biomicroscopy. Five normal patients with IOP≤14 mmHg constitute the control group. A chitosan-based insert of bimatoprost was placed at the upper conjunctival fornix of the right eye. In the left eye, patients used one drop of LumiganTM daily at 10:00 pm. For statistical analysis, we used a two-way analysis of variance (ANOVA), Student t-test, and paired t-test. Results: Sixteen POAG and 13 OH patients with a mean age of 61 years were assessed. In both eyes, IOP reduction was similar during three weeks of follow-up (19.5±2.2 mmHg and 16.9±3.1 mmHg), insert, and eye drop, respectively; P=0.165). The percentage of IOP reduction in the third week was 30% for insert and 35% for eye drops (P=0.165). No intolerance or discomfort with the insert was reported. Among the research participants, 58% preferred the use of the insert while 25% preferred eye drops, and 17% reported no preference. Conclusions: Bimatoprost-loaded inserts showed similar efficacy to daily bimatoprost eye drops during three weeks of follow up, without major side effects. This might suggest a possible change in the daily therapeutic regimen for the treatment of POAG and OH.

scholarly journals The Role of Optical Coherence Tomography Angiography in Moderate and Advanced Primary Open-Angle Glaucoma

2021 ◽  
Author(s):  
Yadollah Eslami ◽  
Sepideh Ghods ◽  
Massood Mohammadi ◽  
Mona Safizadeh ◽  
Ghasem Fakhraie ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Vessel Density ◽  
Mean Deviation ◽  
Optical Coherence ◽  
Open Angle ◽  
The Mean ◽  
Inferior Quadrant

Abstract Purpose: To evaluate the relationship between structure and function in moderate and advanced primary open-angle glaucoma (POAG) and to determine the accuracy of structure and vasculature for discriminating moderate from advanced POAG.Methods: In this cross-sectional study 25 eyes with moderate and 40 eyes with advanced POAG were enrolled. All eyes underwent measurement of the thickness of circumpapillary retinal nerve fiber layer (cpRNFL) and macular ganglion cell complex (GCC), and optical coherence tomography angiography (OCTA) of the optic nerve head (ONH) and macula. Visual field (VF) was evaluated by Swedish interactive threshold algorithm and 24-2 and 10-2 patterns. The correlation between structure and vasculature and the mean deviation (MD) of the VFs was evaluated by a partial correlation coefficient. The area under the receiver operating characteristic curve (AUC) was applied for assessing the power of variables for discrimination moderate from advanced POAG.Results: Superior cpRNFL, superior GCC, whole image vessel density (wiVD) of the ONH area, and vessel density in inferior quadrant of perifovea had the strongest correlation with the mean deviation (MD) of the VF 24-2 (r= .351, .558, .649 and .397; p< .05). The greatest AUCs belonged to inferior cpRNFL (.789), superior GCC (.818), vessel density of the inferior hemifield of ONH area (.886), and vessel density in inferior quadrant of perifovea (.833) without statistically significant difference in pairwise comparison.Conclusion: Vasculature has a stronger correlation than the structure with MD in moderate and advanced POAG and is as accurate as structure in discrimination moderate from advanced POAG.

scholarly journals Systemic risk factors for developing of primary open-angle glaucoma

2018 ◽  
pp. 140-145
Author(s):  
E.A. Egorov ◽  
◽  
V.P. Erichev ◽  
A.L. Onishchenko ◽  
S.Yu. Petrov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Risk ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Systemic Risk Factors
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