scholarly journals Crisaborole: Application Pain and Prevention

2019 ◽  
Vol 13 (1) ◽  
pp. 55-57
Author(s):  
Madison Anzelc ◽  
Craig G. Burkhart
Keyword(s):  
Effective Treatment ◽  
Treatment Modality ◽  
Calcineurin Inhibitors ◽  
Pde4 Inhibitor ◽  
Application Site ◽  
Phosphodiesterase 4 ◽  
Effective Treatment Modality ◽  
Increased Sensitivity ◽  
First Time ◽  
Sensitivity To Pain

In 2016, a new drug, crisaborole, was developed and approved, for the first time in 15 years, as an effective treatment for Atopic Dermatitis (AD). Crisaborole is a topical phosphodiesterase 4 (PDE4) inhibitor, which alleviates AD symptoms, such as pruritis, inflammation, and flares. Similar to other topical treatments like corticosteroids and calcineurin inhibitors, crisaborole has been found to cause pain during application. The pain felt during a topical application can be attributed to many possible causes, such as increased sensitivity to pain-provoking and itch-provoking stimuli, prior inflammation, prior damage, and hypersensitized skin of the patient to which the topical cream is applied. Crisaborole has been reported to be effective, yet the application site pain is a major road bump in the effective treatment of some patients. Some possible ways to circumvent this pain are letting the epidermis soothe and heal before starting crisaborole, starting this treatment modality before the skin has a chance to become irritated and inflamed, and numbing the area with an ice pack prior to topical crisaborole application. Overall, crisaborole has been an effective treatment modality, but further research is necessary to allow for safe use of this life-changing AD topical medication.

Benign Intracranial Lesions - Radiotherapy: An Overview of Treatment Options, Indications and Therapeutic Results

2020 ◽  
Vol 15 (2) ◽  
pp. 93-121
Author(s):  
Vasileios Tzikoulis ◽  
Areti Gkantaifi ◽  
Filippo Alongi ◽  
Nikolaos Tsoukalas ◽  
Haytham Hamed Saraireh ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Treatment Modality ◽  
Radiation Effects ◽  
Treatment Options ◽  
Proton Beam Therapy ◽  
Tumor Control ◽  
Control Growth ◽  
Effective Treatment Modality ◽  
Intracranial Lesions

Background: Radiation Therapy (RT) is an established treatment option for benign intracranial lesions. The aim of this study is to display an update on the role of RT concerning the most frequent benign brain lesions and tumors. Methods: Published articles about RT and meningiomas, Vestibular Schwannomas (VSs), Pituitary Adenomas (PAs), Arteriovenous Malformations (AVMs) and craniopharyngiomas were reviewed and extracted data were used. Results: In meningiomas RT is applied as an adjuvant therapy, in case of patientrefusing surgery or in unresectable tumors. The available techniques are External Beam RT (EBRT) and stereotactic ones such as Stereotactic Radiosurgery (SRS), Fractionated Stereotactic RT (FSRT), Intensity Modulated RT (IMRT) and proton-beam therapy. The same indications are considered in PAs, in which SRS and FSRT achieve excellent tumor control rate (92-100%), acceptable hormone remission rates (>50%) and decreased Adverse Radiation Effects (AREs). Upon tumor growth or neurological deterioration, RT emerges as alone or adjuvant treatment against VSs, with SRS, FSRT, EBRT or protonbeam therapy presenting excellent tumor control growth (>90%), facial nerve (84-100%), trigeminal nerve (74-99%) and hearing (>50%) preservation. SRS poses an effective treatment modality of certain AVMs, demonstrating a 3-year obliteration rate of 80%. Lastly, a combination of microsurgery and RT presents equal local control and 5-year survival rate (>90%) but improved toxicity profile compared to total resection in case of craniopharyngiomas. Conclusion: RT comprises an effective treatment modality of benign brain and intracranial lesions. By minimizing its AREs with optimal use, RT projects as a potent tool against such diseases.

scholarly journals THE EFFECTIVENESS OF USAGE TRIACORTUM, CLOTRIMAZOLE AND DOXYCYCLINE FOR CHRONIC APICAL PERIODONTITIS TREATMENT

World Science ◽  
2019 ◽  
Vol 3 (6(46)) ◽  
pp. 18-21
Author(s):  
Korniichuk O. E.
Keyword(s):  
Effective Treatment ◽  
Treatment Modality ◽  
Antifungal Agent ◽  
Apical Periodontitis ◽  
Clinical Judgement ◽  
Doppler Flowmetry ◽  
Effective Treatment Modality

This article represents the work for searching new and effective treatment modality for chronic forms of periodontitis with application of the antibiotic doxycycline, antifungal agent clotrimazole and glucocorticosteroid triacortum.It was made the clinical judgement of treatment of 150 patients with chronic apical periodontitis. It was indicated an improvement of microcirculation in periodontitis tissue by Lazer Doppler flowmetry method by those patients who received therapy using proposed method of treatment and set of medication.

Total contact casting

1995 ◽  
Vol 85 (3) ◽  
pp. 172-176 ◽  
Author(s):  
RE Baker
Keyword(s):  
Effective Treatment ◽  
Diabetic Foot ◽  
Treatment Modality ◽  
Treatment Method ◽  
Complex Treatment ◽  
Effective Treatment Modality ◽  
Total Contact Casting ◽  
Neuropathic Foot

The treatment of diabetic foot ulcerations has been a difficult task for podiatrists. Numerous methods and materials have been used in an attempt to alleviate this frustrating and complex treatment dilemma. However, there is one treatment method that has been used successfully for decades on plantar ulcerations of the neuropathic foot. Total contact casting has been an easily applicable and effective treatment modality for neuropathic ulcerations of the diabetic foot.

Peroral Endoscopic Myotomy (POEM) Is an Effective Treatment Modality for All Subtypes of Achalasia

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S236-S237
Author(s):  
Madhusudhan R. Sanaka ◽  
Malav P. Parikh ◽  
Subanandhini Subramaniam ◽  
Prasanthi N. Thota ◽  
Niyati M. Gupta ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Treatment Modality ◽  
Peroral Endoscopic Myotomy ◽  
Effective Treatment Modality ◽  
Endoscopic Myotomy
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