Would Polymorphic Variants of Dopamine-2 Receptor Gene (DRD2) and Serotonin Transporter Gene (SERT) be a Common Genetic Risk Factor for Comorbid Drug Abuse and Myocardial Ischemia? A Hypothesis- generating Study

2018 ◽  
Vol 15 (2) ◽  
pp. 129-143 ◽  
Author(s):  
Yasmeen M. Taalab ◽  
Doaa A. Elmorsi ◽  
Imke Puls ◽  
Andreas Heinz ◽  
Abdel-Aziz Ghanem ◽  
...  
Keyword(s):  
Risk Factor ◽  
Drug Abuse ◽  
Myocardial Ischemia ◽  
Serotonin Transporter ◽  
Genetic Risk ◽  
Receptor Gene ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Polymorphic Variants ◽  
Dopamine 2 Receptor

Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene ⋆

2003 ◽  
Vol 18 (2) ◽  
pp. 77-81 ◽  
Author(s):  
Hasan Herken ◽  
M. Emin Erdal ◽  
Ömer Böke ◽  
Haluk A. Savaş
Keyword(s):  
Tardive Dyskinesia ◽  
Serotonin Transporter ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Comt Gene ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Methyltransferase Gene ◽  
Schizophrenic Patients ◽  
And Control

AbstractBackgroundThe pathophysiology of tardive dyskinesia (TD) is not completely understood.AimTo assess the relationship of TD with 5-HT2A receptor gene, serotonin transporter gene (5 HTT), and catechol-o-methyltransferase (COMT) gene polymorphisms.MethodsOur study comprised 111 unrelated subjects who strictly met DSM-IV criteria for schizophrenia and 32 TD, and 79 healthy unrelated controls; all the subjects were of Turkish origin. The analyses of 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were performed using polymerase chain reaction (PCR) technique.ResultsThe polymorphisms of these genes were not significantly different between the schizophrenic patients, TD and control subjects.ConclusionsOur findings indicated that 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were similar in schizophrenia with non-TD, schizophrenia with TD, and healthy controls. These polymorphisms, though, do not help to evaluate the susceptibility to TD.

Serotonin Transporter Gene Variation Is a Risk Factor for Sudden Infant Death Syndrome in the Japanese Population

PEDIATRICS ◽  
2001 ◽  
Vol 107 (4) ◽  
pp. 690-692 ◽  
Author(s):  
Naoko Narita ◽  
Masaaki Narita ◽  
Sachio Takashima ◽  
Masahiro Nakayama ◽  
Toshiro Nagai ◽  
...  
Keyword(s):  
Risk Factor ◽  
Serotonin Transporter ◽  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Japanese Population ◽  
Sudden Infant Death ◽  
Serotonin Transporter Gene ◽  
Sudden Infant ◽  
Transporter Gene ◽  
Gene Variation

Association of anxiety level with polymorphic variants of serotonin transporter gene in Russians and Tuvinians

2015 ◽  
Vol 5 (6) ◽  
pp. 656-665 ◽  
Author(s):  
A. N. Savostyanov ◽  
V. S. Naumenko ◽  
N. A. Sinyakova ◽  
M. N. L’vova ◽  
E. A. Levin ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Anxiety Level ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Polymorphic Variants

scholarly journals Short Allele of Serotonin Transporter Gene Promoter Is a Risk Factor for Obesity in Adolescents*

Obesity ◽  
2007 ◽  
Vol 15 (2) ◽  
pp. 271-276 ◽  
Author(s):  
Silvia Sookoian ◽  
Carolina Gemma ◽  
Silvia I. García ◽  
Tomas Fernández Gianotti ◽  
Guillermo Dieuzeide ◽  
...  
Keyword(s):  
Risk Factor ◽  
Serotonin Transporter ◽  
Gene Promoter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Short Allele

scholarly journals Allelic polymorphism in the serotonin transporter gene in major depression patients*

2011 ◽  
pp. 48-53 ◽  
Author(s):  
Carlos H Escobar ◽  
Jorge Hernán Calderón ◽  
Germán Alberto Moreno
Keyword(s):  
Risk Factor ◽  
Major Depression ◽  
Confidence Interval ◽  
Mood Disorders ◽  
Serotonin Transporter ◽  
Protective Factor ◽  
Serotonin Transporter Gene ◽  
Allelic Polymorphism ◽  
Transporter Gene ◽  
Wide Confidence Interval

Introduction: Major depression (MD), like other mood disorders, is considered a worldwide endemic pathology, becoming one of the biggest public health problems. The hereditary factors of mood disorders have been studied for many years and different chromosomal regions and genes have been involved in this physiopathological process. Objective: To establish the association between allelic variants of the serotonin transporter gene (5-HTTLPR and VNTR) and MD in a population with this diagnostic in the department of Caldas, Colombia. Materials and methods: A case-control study was conducted with individuals older than 16 years of age born in the department of Caldas. The sample was composed of 59 patients with the MD with family antecedents of the pathology and 59 controls paired by precedence, age, and gender. For the cases and controls selection the Diagnostic Interview for Genetic Studies (DIGS) was used. Using the Hranilovic et al. protocol, the polymorphic regions in the promoter and third intron of the Serotonin Transporter gene was amplified. Results: It was not possible to find association between MD and the genetic or clinical variables. The absence of the short allele of the promoter could act as a protective factor (OR=0.70 CI 95%=0.313 to 1.604), for the development of the pathology in this population, and the presence of at least one copy of the 10 repetition alleles of the third intron could act as a risk factor (OR: 1.25), but the wide confidence interval (CI 95%=0.38 to 2.64) does not permit supporting these conclusions. Discussion: The results obtained in this population do not yield conclusive information related with the etiopathogeny of MD, but do not contradict those obtained in other studies with bigger samples than ours. The broad confidence interval does not support conclusions about the role as a risk factor for the 10 repetition alleles of the intron or the absence of the S allele of the promoter as a protector factor. Further studies with larger population samples may help to clarify these facts.

Sign in / Sign up

Export Citation Format

Share Document