Microwave-assisted C-C and C-heteroatom bond formations in aqueous medium

2021 ◽  
Vol 08 ◽  
Author(s):  
Bijeta Mitra ◽  
Pranab Ghosh
Keyword(s):  
Reaction Time ◽  
Aqueous Medium ◽  
Organic Synthesis ◽  
Bioactive Compounds ◽  
Bond Formation ◽  
Reaction Medium ◽  
Microwave Assisted ◽  
Reaction Condition ◽  
Mother Earth ◽  
Bond Formation Reactions

: In recent times, microwave assisted chemistry have gained enormous attraction in organic synthesis owing to its versatile advantages such as avoidance of harsh reaction condition, increase of yield, eliminates of by product, shorter reaction time and removal of wastages. Besides, water as a reaction medium further includes more benefit as it eliminates all the drawbacks of toxic solvent which may cause injuries for our mother earth. Furthermore C-C and C-heteroatom bond formation reactions are very significant as most of the drug as well as bioactive compounds contain heterocycles or C-hetero bond which is a key tool of chemistry. This article demonstrates the advancement on the topic of the microwave assisted C-C and C-heteroatom bond formation reactions in aqueous medium.

scholarly journals Microwave Assisted Synthesis of 1,5-Benzothiazepines Using Greener Reaction Medium

2019 ◽  
Vol 31 (5) ◽  
pp. 993-996 ◽  
Author(s):  
Sanjay S. Kotalwar ◽  
Amol D. Kale ◽  
Ram B. Kohire ◽  
Vasant B. Jagrut
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Reaction Medium ◽  
Microwave Assisted Synthesis ◽  
Reaction Conditions ◽  
Renewable Sources ◽  
Microwave Assisted ◽  
High Yields

An efficient and eco-friendly synthesis of 1,5-benzothiazepines has been developed by the reaction of various 2-propen-1-ones with 2-aminothiophenol using microwave irradiation in greener reaction medium, glycerol. The clean reaction conditions, shorter reaction time, high yields and non-toxic, biodegradable reaction medium manufactured from renewable sources are unique features of this method.

ChemInform Abstract: Microwave Assisted Synthesis of 2-Aminooxazolo[4,5-b]pyridine Derivatives via Intramolecular C-O Bond Formation in Aqueous Medium.

ChemInform ◽  
2014 ◽  
Vol 45 (31) ◽  
pp. no-no
Author(s):  
Umesh B. Kosurkar ◽  
Tulshiram L. Dadmal ◽  
K. Appalanaidu ◽  
Y. Khageswara Rao ◽  
Jagadeesh B. Nanubolu ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Bond Formation ◽  
Microwave Assisted Synthesis ◽  
Pyridine Derivatives ◽  
Microwave Assisted

Repurposing fallen leaves to bio-based reaction medium for hydration, hydroxylation, carbon-carbon and carbon-nitrogen bond formation reactions

2020 ◽  
Vol 15 ◽  
pp. 100225 ◽  
Author(s):  
Sameeran Kumar Das ◽  
Khairujjaman Laskar ◽  
Dipika Konwar ◽  
Aniket Sahoo ◽  
Binoy K. Saikia ◽  
...  
Keyword(s):  
Bond Formation ◽  
Reaction Medium ◽  
Fallen Leaves ◽  
Nitrogen Bond ◽  
Bond Formation Reactions

1.10 Boron-Centered Radicals

2021 ◽  
Author(s):  
F.-L. Zhang ◽  
Y.-F. Wang
Keyword(s):  
Organic Synthesis ◽  
Bond Formation ◽  
Radical Species ◽  
Reduction Reactions ◽  
Radical Intermediates ◽  
Radical Catalysis ◽  
Bond Formation Reactions

AbstractBoryl radicals have emerged as powerful radical intermediates in organic synthesis. This review summarizes recently developed transformations involving boryl radical species, including C—B bond formation reactions, reduction reactions, and radical catalysis.

Microwave-Assisted Synthesis of 2-(2-Nitroethenly)thiophene from 2-Thiophenecarboxaldehyde and Nitromethane

2012 ◽  
Vol 268-270 ◽  
pp. 500-503
Author(s):  
Jun De Xing ◽  
Zhi Liu ◽  
Zhao Yu Zhang ◽  
Xiao Fei Jia
Keyword(s):  
Energy Source ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Knoevenagel Condensation ◽  
Microwave Assisted Synthesis ◽  
Beta Alanine ◽  
Microwave Assisted ◽  
Reaction Condition ◽  
Efficient Access

2-(2-Nitroethenly)thiophene can be obtained from 2-thiophenecarboxaldehyde and nitromethane under Knoevenagel condensation conditions. We used beta-alanine as a catalyst and microwave irradiation as the energy source. Different reaction condition, such as beta-alanine consumption and reaction time were studied. The results indicate that the application of microwave irradiation increases the yield of desired compound. beta-Alanine-catalyzed activation of 2-thiophenecarboxaldehyde provides an efficient access to 2-(2-nitroethenly)thiophene with reusability of the catalyst.

Microwave-assisted C-C, C-O, C-N, C-S bond formation and multicomponent reactions using magnetic retrievable nanocatalysts

2021 ◽  
Vol 08 ◽  
Author(s):  
Manavi Yadav ◽  
Mahima Dutta ◽  
Pema Tanwar ◽  
Reena Jain ◽  
Anju Srivastava ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Bond Formation ◽  
Activation Parameters ◽  
Cost Effective ◽  
Molecular Scaffolds ◽  
Bond Forming ◽  
Microwave Assisted ◽  
Work Up ◽  
Reaction Media ◽  
Yield And Purity

: Microwave-assisted organic synthesis has been perceived as one of the most powerful and sustainable tools to accomplish expeditious organic synthesis through a greener way on account of its specific features including targeted heating, reaction homogeneity, rapidity, possible modifications of activation parameters, improved selectivity, yield and purity, along with simpler work-up. Another rapidly growing field for the development of green and sustainable protocol is the application of the magnetic nanocatalysts. They not only meet the need for facile recovery from the reaction media after completion of a reaction but also provide the best attributes of nanotechnology along with the elimination of auxiliary substances and catalyst loss, thereby, making the overall process clean, fast and cost-effective. Thus, the amalgamation of magnetic nanocatalysts and microwave irradiation present an ideal blend for the development of sustainable methods in synthetic organic chemistry. Amidst various bond forming reactions, carbon-carbon (C–C) and carbon-heteroatom (C-X, where X= O, N, S) bond formations are essentially used to devise privileged molecular scaffolds for synthetic organic and medicinal chemistry. This review gives a succinct overview of the synthesis and application of various modified magnetic nanocomposites as task-specific catalysts for microwave assisted C-C and C-X bond formation reactions in recent years. (This review consists of more than 190 references)

Nano Copper Catalyzed Microwave Assisted Coupling of Benzene Boronic Acids with Thiophenols

2019 ◽  
Vol 16 (6) ◽  
pp. 491-494
Author(s):  
Dinesh S. Gavhane ◽  
Aniket P. Sarkate ◽  
Kshipra S. Karnik ◽  
Shritesh D. Jagtap ◽  
Sajed H. Ansari ◽  
...  
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Bond Formation ◽  
Boronic Acids ◽  
Conventional Heating ◽  
Microwave Technique ◽  
Microwave Assisted ◽  
Measurable Amount ◽  
Ligand Free

A proficient, microwave mediated methodology using CuFe2O4 nanoparticle as the catalyst for S-arylation of substituted benzene boronic acids with thiophenol has been developed. In this method, the substituted thioethers were easily obtained through a C-S bond formation using microwave irradiation technique as well as conventional heating in the presence of CuFe2O4 nanoparticles with modest to excellent yields with the less reaction time. The ligand free microwave technique helped in the preparation of substituted thioethers in measurable amount within 10 mins. The same results were obtained with conventional heating in 12h. The reported method is economically efficient and an alternative to the initial existing method for the preparation of substituted thioethers.

Microwave-Assisted Cp*CoIII-Catalyzed C–H Activation/Double C–N Bond Formation Reactions to Thiadiazine 1-Oxides

2017 ◽  
Vol 19 (5) ◽  
pp. 1128-1131 ◽  
Author(s):  
Jiapian Huang ◽  
Yangfei Huang ◽  
Tao Wang ◽  
Qin Huang ◽  
Zhihua Wang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Microwave Assisted ◽  
Bond Formation Reactions
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