Microwave-assisted C-C, C-O, C-N, C-S bond formation and multicomponent reactions using magnetic retrievable nanocatalysts

2021 ◽  
Vol 08 ◽  
Author(s):  
Manavi Yadav ◽  
Mahima Dutta ◽  
Pema Tanwar ◽  
Reena Jain ◽  
Anju Srivastava ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Bond Formation ◽  
Activation Parameters ◽  
Cost Effective ◽  
Molecular Scaffolds ◽  
Bond Forming ◽  
Microwave Assisted ◽  
Work Up ◽  
Reaction Media ◽  
Yield And Purity

: Microwave-assisted organic synthesis has been perceived as one of the most powerful and sustainable tools to accomplish expeditious organic synthesis through a greener way on account of its specific features including targeted heating, reaction homogeneity, rapidity, possible modifications of activation parameters, improved selectivity, yield and purity, along with simpler work-up. Another rapidly growing field for the development of green and sustainable protocol is the application of the magnetic nanocatalysts. They not only meet the need for facile recovery from the reaction media after completion of a reaction but also provide the best attributes of nanotechnology along with the elimination of auxiliary substances and catalyst loss, thereby, making the overall process clean, fast and cost-effective. Thus, the amalgamation of magnetic nanocatalysts and microwave irradiation present an ideal blend for the development of sustainable methods in synthetic organic chemistry. Amidst various bond forming reactions, carbon-carbon (C–C) and carbon-heteroatom (C-X, where X= O, N, S) bond formations are essentially used to devise privileged molecular scaffolds for synthetic organic and medicinal chemistry. This review gives a succinct overview of the synthesis and application of various modified magnetic nanocomposites as task-specific catalysts for microwave assisted C-C and C-X bond formation reactions in recent years. (This review consists of more than 190 references)

Microwave-accelerated Carbon-carbon and Carbon-heteroatom Bond Formation via Multi-component Reactions: A Brief Overview

2020 ◽  
Vol 7 (1) ◽  
pp. 23-39 ◽  
Author(s):  
Kantharaju Kamanna ◽  
Santosh Y. Khatavi
Keyword(s):  
Organic Synthesis ◽  
Bond Formation ◽  
Cycloaddition Reaction ◽  
Nanoparticle Synthesis ◽  
Single Step ◽  
Bioactive Molecules ◽  
One Pot ◽  
Bond Forming ◽  
Material Interest ◽  
Carbon Carbon Bond

Multi-Component Reactions (MCRs) have emerged as an excellent tool in organic chemistry for the synthesis of various bioactive molecules. Among these, one-pot MCRs are included, in which organic reactants react with domino in a single-step process. This has become an alternative platform for the organic chemists, because of their simple operation, less purification methods, no side product and faster reaction time. One of the important applications of the MCRs can be drawn in carbon- carbon (C-C) and carbon-heteroatom (C-X; X = N, O, S) bond formation, which is extensively used by the organic chemists to generate bioactive or useful material synthesis. Some of the key carbon- carbon bond forming reactions are Grignard, Wittig, Enolate alkylation, Aldol, Claisen condensation, Michael and more organic reactions. Alternatively, carbon-heteroatoms containing C-N, C-O, and C-S bond are also found more important and present in various heterocyclic compounds, which are of biological, pharmaceutical, and material interest. Thus, there is a clear scope for the discovery and development of cleaner reaction, faster reaction rate, atom economy and efficient one-pot synthesis for sustainable production of diverse and structurally complex organic molecules. Reactions that required hours to run completely in a conventional method can now be carried out within minutes. Thus, the application of microwave (MW) radiation in organic synthesis has become more promising considerable amount in resource-friendly and eco-friendly processes. The technique of microwaveassisted organic synthesis (MAOS) has successfully been employed in various material syntheses, such as transition metal-catalyzed cross-coupling, dipolar cycloaddition reaction, biomolecule synthesis, polymer formation, and the nanoparticle synthesis. The application of the microwave-technique in carbon-carbon and carbon-heteroatom bond formations via MCRs with major reported literature examples are discussed in this review.

Recent Advances in C–Br Bond Formation

Synlett ◽  
2021 ◽  
Author(s):  
Ying-Yeung Yeung ◽  
Jonathan Wong
Keyword(s):  
Organic Synthesis ◽  
Aromatic Compounds ◽  
Bond Formation ◽  
Cross Coupling ◽  
Catalytic Site ◽  
Atom Transfer ◽  
Bond Forming ◽  
Recent Advances ◽  
Catalytic Asymmetric ◽  
Site Selective

AbstractOrganobromine compounds are extremely useful in organic synthesis. In this perspective, a focused discussion on some recent advancements in C–Br bond-forming reactions is presented.1 Introduction2 Selected Recent Advances2.1 Catalytic Asymmetric Bromopolycyclization of Olefinic Substrates2.2 Catalytic Asymmetric Intermolecular Bromination2.3 Some New Catalysts and Reagents for Bromination2.4 Catalytic Site-Selective Bromination of Aromatic Compounds2.5 sp3 C–H Bromination via Atom Transfer/Cross-Coupling3 Outlook

Hydrolase-catalyzed asymmetric carbon–carbon bond formation in organic synthesis

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 16801-16814 ◽  
Author(s):  
Zhi Guan ◽  
Ling-Yu Li ◽  
Yan-Hong He
Keyword(s):  
Organic Synthesis ◽  
Bond Formation ◽  
Carbon Bond ◽  
Bond Forming ◽  
Carbon Carbon Bond ◽  
Bond Forming Reactions ◽  
Asymmetric Carbon

This article reviews the hydrolase-catalyzed asymmetric carbon–carbon bond-forming reactions for the preparation of enantiomerically enriched compounds in organic synthesis.

Microwave-Assisted Tandem Processes for the Synthesis of N-Heterocycles

2009 ◽  
Vol 62 (3) ◽  
pp. 208 ◽  
Author(s):  
Mohammed Abid ◽  
Béla Török ◽  
Xudong Huang
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Significant Contribution ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Reaction Rates ◽  
Phase Synthesis ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
Reaction Media

Over the years, microwave-assisted organic synthesis (MAOS) became a commonly applied mainstream tool for the synthesis of heterocyclic compounds. The broad range of emerging applications in this field is mainly due to the significant contribution of MAOS to the development of ecofriendly processes. Various transformations have been developed for the synthesis of N-heterocycles under microwave conditions, including fast and selective processes. Tandem reactions involving greener reaction media, solvent-free conditions, and solid-phase synthesis are of exceptional interest in this area. In most transformations, microwave conditions dramatically enhanced reaction rates, as well as provided improved yields. This account highlights the most recent advancements in MAOS-based tandem processes for the synthesis of N-heterocycles.

Microwave-assisted C-C and C-heteroatom bond formations in aqueous medium

2021 ◽  
Vol 08 ◽  
Author(s):  
Bijeta Mitra ◽  
Pranab Ghosh
Keyword(s):  
Reaction Time ◽  
Aqueous Medium ◽  
Organic Synthesis ◽  
Bioactive Compounds ◽  
Bond Formation ◽  
Reaction Medium ◽  
Microwave Assisted ◽  
Reaction Condition ◽  
Mother Earth ◽  
Bond Formation Reactions

: In recent times, microwave assisted chemistry have gained enormous attraction in organic synthesis owing to its versatile advantages such as avoidance of harsh reaction condition, increase of yield, eliminates of by product, shorter reaction time and removal of wastages. Besides, water as a reaction medium further includes more benefit as it eliminates all the drawbacks of toxic solvent which may cause injuries for our mother earth. Furthermore C-C and C-heteroatom bond formation reactions are very significant as most of the drug as well as bioactive compounds contain heterocycles or C-hetero bond which is a key tool of chemistry. This article demonstrates the advancement on the topic of the microwave assisted C-C and C-heteroatom bond formation reactions in aqueous medium.

A Review on Recent Advances in the Synthesis of Aziridines and their Applications in Organic Synthesis

2021 ◽  
Vol 25 ◽  
Author(s):  
Tanzeela Qadir ◽  
Andleeb Amin ◽  
Deeptanu Sarkar ◽  
Praveen Kumar Sharma
Keyword(s):  
Organic Synthesis ◽  
Cost Effective ◽  
High Reactivity ◽  
Small Ring ◽  
Cyclic Amines ◽  
Electrophilic Reagents ◽  
Synthetic Intermediates ◽  
Synthetic Approaches ◽  
Work Up ◽  
Stable Ring

: Aziridines are the saturated three-membered cyclic amines that constitute an important group of synthetic intermediates. These could act as a precursor for diverse organic compounds owing to the reactivity due to the ring strain associated with them. The outstanding property of aziridines is their high reactivity towards various nucleophilic and electrophilic reagents to acquire more stable ring-opened or ring-expanded amines that could be obtained from the release of strain energy intrinsic in a small ring. As such, aziridines could be used in the synthesis of 4-7 membered heterocycles of biological and industrial significance, such as azetidines, imidazoles, thiazoles, pyrazines, pyrimidines, benzothiazines, benzodiazepines, etc. Earlier synthesis of aziridines was considered a laborious task due to their instability. However, various synthetic approaches leading to the formation of aziridines are now available in the literature. Recently, green, cost-effective and approaches based on simpler work-up for these reactions have attracted researcher's attention. This review article deals with synthetic routes of aziridines and aziridine applications in organic synthesis.

scholarly journals Nucleophilic Trifluoromethylation Reactions Involving Copper(I) Species: From Organometallic Insights to Scope

Synthesis ◽  
2019 ◽  
Vol 51 (14) ◽  
pp. 2809-2820 ◽  
Author(s):  
Ángel L. Mudarra ◽  
Sara Martínez de Salinas ◽  
Mónica H. Pérez-Temprano
Keyword(s):  
Organic Synthesis ◽  
Historical Perspective ◽  
Short Review ◽  
Copper Species ◽  
Bond Forming ◽  
Comprehensive Picture ◽  
Real Behavior ◽  
In Situ Generation ◽  
Reaction Media

Over the last decades, trifluoromethyl copper(I) complexes have played a key role as reactive species in C–CF3 bond-forming reactions. This Short Review not only covers selected examples of relevant copper-mediated or catalyzed nucleophilic trifluoromethylation reactions, which is one of the most active fields in organic synthesis, but also provides a comprehensive picture of the real behavior of these copper species, including ubiquitous cuprates, in the reaction media.1 Introduction2 Historical Perspective of the Identification of Relevant Trifluoro- methyl Copper(I) Species3 In Situ Generation of Active Trifluoromethyl Copper(I) Species 4 Well-Defined Active Trifluoromethyl Copper(I) Complexes5 Recent Advances on the Performance of Trifluoromethylation Protocols6 Conclusions

Corrigendum to: Microwave-Assisted Tandem Processes for the Synthesis of N-Heterocycles

2009 ◽  
Vol 62 (4) ◽  
pp. 392
Author(s):  
Mohammed Abid ◽  
Béla Török ◽  
Xudong Huang
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Significant Contribution ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Reaction Rates ◽  
Phase Synthesis ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
Reaction Media

Over the years, microwave-assisted organic synthesis (MAOS) became a commonly applied mainstream tool for the synthesis of heterocyclic compounds. The broad range of emerging applications in this field is mainly due to the significant contribution of MAOS to the development of ecofriendly processes. Various transformations have been developed for the synthesis of N-heterocycles under microwave conditions, including fast and selective processes. Tandem reactions involving greener reaction media, solvent-free conditions, and solid-phase synthesis are of exceptional interest in this area. In most transformations, microwave conditions dramatically enhanced reaction rates, as well as provided improved yields. This account highlights the most recent advancements in MAOS-based tandem processes for the synthesis of N-heterocycles.

scholarly journals Potassium Carbonate Assisted Synthesis Of α, β, γ, δ-Unsaturated Ketones

2020 ◽  
Vol 8 (2) ◽  
pp. 17-25
Author(s):  
Pramod Kulkarni ◽  
Sammer Gawade
Keyword(s):  
Organic Synthesis ◽  
Potassium Carbonate ◽  
Reaction Times ◽  
High Yield ◽  
Direct Reaction ◽  
Purification Process ◽  
Unsaturated Ketones ◽  
Medicinal Properties ◽  
Work Up ◽  
Yield And Purity

The Cinnamylideneacetophenones derivative is shows important medicinal properties and intermediate in organic synthesis. Several substituted α, β, γ, δ-Unsaturated Ketones were prepared in high yield and purity by direct reaction of substituted cinnamaldehyde and ketones in the presence of potassium carbonate as a base in ethanol at 50ºC. The merit of the method is short reaction times, high yield, easy work-up and purification process, inexpensive and easily available catalyst.

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