Advances in Cancer Drug Targets

To define the growing significance of cellular targets and/or effectors of cancer drugs, we examined the fitness dependency of cellular targets and effectors of cancer drug targets across human cancer cells from 19 cancer types. We observed that the deletion of 35 out of 47 cellular effectors and/or targets of oncology drugs did not result in the expected loss of cell fitness in appropriate cancer types for which drugs targeting or utilizing these molecules for their actions were approved. Additionally, our analysis recognized 43 cellular molecules as fitness genes in several cancer types in which these drugs were not approved, and thus, providing clues for repurposing certain approved oncology drugs in such cancer types. For example, we found a widespread upregulation and fitness dependency of several components of the mevalonate and purine biosynthesis pathways (currently targeted by bisphosphonates, statins, and pemetrexed in certain cancers) and an association between the overexpression of these molecules and reduction in the overall survival duration of patients with breast and other hard-to-treat cancers, for which such drugs are not approved. In brief, the present analysis raised cautions about off-target and undesirable effects of certain oncology drugs in a subset of cancers where the intended cellular effectors of drug might not be good fitness genes and that this study offers a potential rationale for repurposing certain approved oncology drugs for targeted therapeutics in additional cancer types.

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Validating cancer drug targets through chemical genetics

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer ◽

10.1016/j.bbcan.2010.08.002 ◽

2010 ◽

Vol 1806 (2) ◽

pp. 251-257

Author(s):

Mark E. Burkard ◽

Prasad V. Jallepalli

Keyword(s):

Drug Targets ◽

Chemical Genetics ◽

Cancer Drug

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Signal Transduction Pathways in Breast Cancer – Drug Targets and Challenges

Breast Cancer - Carcinogenesis, Cell Growth and Signalling Pathways ◽

10.5772/23855 ◽

2011 ◽

Author(s):

Samar Azab ◽

Ayman Al-Hendy

Keyword(s):

Breast Cancer ◽

Signal Transduction ◽

Drug Targets ◽

Cancer Drug ◽

Signal Transduction Pathways

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Synthesis, Spectral, Bio Assay, Chromatographic - Studying of New Imidazole Reagents Via Three Components Reaction

NeuroQuantology ◽

10.14704/nq.2021.19.7.nq21092 ◽

2021 ◽

Vol 19 (7) ◽

pp. 115-122

Author(s):

Mohammed Nawfal Abdul Maged Alkhafaji ◽

Hutham Abd Ali Abd Al Hussain ◽

Dr. Nagham Mahmood Aljamali

Keyword(s):

Nervous System ◽

Drug Targets ◽

Biological Activities ◽

Drug Carrier ◽

Chemical Properties ◽

Cancer Drug ◽

Condensation Process ◽

Chromatographic Study ◽

The Central Nervous System ◽

Physical And Chemical

Imidazoles are part of the theophylline Reagent, found in tea leaves and coffee beans, which stimulates the central nervous system. It is found in the anti-cancer drug mercaptopurine, which fights leukemia by interfering with DNA systems. A number of prepared imidazoles, including clotrimazole, are selective inhibitors of nitric oxide synthase, which makes them interesting drug targets in inflammation, respiratory diseases and tumors of the nervous system. Other biological activities of the drug carrier imidazole relate to deregulation of the intracellular fluxes of (Ca and K) ions. Novel imidazole –heterocyclic reagents were created via cyclization process then condensation process., followed by investigation of all created new reagents via a number of spectral performances (FT.IR, H.NMR)–spectrophotometric, other physical and chemical properties, and chromatographic study with microbial studying for all new created imidazole reagents.

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