A comparative clinical study of Amavatavidhwansa Rasa and Simhanaada Guggulu in the management of Amavata w.s.r. to Rheumatoid Arthritis

Amavata is the most challenging disease for the medical science, as it causes severe intolerable pain and severe deformities making the patient disable and bedridden. As it is the disease of Rasavaha Srotas and having several features similar to Rheumatoid Arthritis, Amavata can be correlated with Rheumatoid Arthritis (RA). Amavata is the outcome of Agnidushti, Amotpatti and Sandhivikrutti, with the passage of the time most of the dietary habits, changing lifestyle and environment have been contributing to the disease, the risk factor include age, gender, genetics and environmental exposures. Hence Amavata have became a challenge to the human race. Management of the disease is merely insufficient in other system of medicine, in such condition disease which continues to pose challenge to the physician as well as for patients due to severe morbidity and crippling nature. So patients are continuously looking for the treatment from Ayurved to overcome this challenge. It also shows extra articular features like bodyache, stiffness etc. many research have been carried out to solve this clinical enigma.The therapy which normalizes Agni metabolizes Ama and regulates Vata and maintain healthy Sandhi and Sandhistha Shelshma will be the supreme one for this disease. The formulations of Amavatavidhvansa Rasa and Simhanaada Guggula is indicated, especially in treating the Amavata.

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Comparative clinical study of Alambushadi Churna and Dwipanchmuladya Tail Basti in the management of Amavata vis-a–vis Rheumatoid Arthritis

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.5.6.3 ◽

2020 ◽

Vol 5 (06) ◽

pp. 20-35

Author(s):

Sunil Kumar1 ◽

J.P. Singh ◽

O.P. Singh ◽

Mukesh Kumar

Keyword(s):

Rheumatoid Arthritis ◽

Clinical Study ◽

Oral Dose ◽

Joint Pain ◽

Diverse Group ◽

Medical Sciences ◽

Appetite Loss ◽

Text Book ◽

Comparative Clinical Study ◽

Loss Of Appetite

In Ayurvedic text book, Amavata symptom is mentioned as swelling, joint pain, numbness, appetite loss, indigestion and fever. In Charaka Samhita and Sushruta Samhita, Amavata is mentioned as a syndrome called Vatavyadhi, a diverse group of symptoms that are organized according to the systemic and local manifestations of Vata Dosha. According to the Charaka Samhita of Vatavyadhi, when Vata affects the Asthi and Majja there is painful swelling and immobility of the joints. Hence clinical study is planned to evaluate effect of Alambushadi Churna and in the Management of Amavata for that 60 Patients having classical symptomatology of Amavata have been selected from Kayachikitsa OPD and IPD of Sir Sunder Lal Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi and divided in two groups. Results of study shows that the sign and symptoms e.g., Loss of appetite, Angamarda, Alasya etc. due to derangement of Aam are observed to be improved in by Alambushadi Churna oral dose compared to Methotrexate.

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A prospective, randomized, double-blind, comparative clinical study of efficacy and safety of a biosimilar adalimumab with innovator product in patients with active rheumatoid arthritis on a stable dose of methotrexate

Indian Journal of Rheumatology ◽

10.4103/0973-3698.233164 ◽

2018 ◽

Vol 13 (2) ◽

pp. 84

Author(s):

Prasad Apsangikar ◽

Sunil Chaudhry ◽

Manoj Naik ◽

Shashank Deoghare ◽

Jamila Joseph

Keyword(s):

Rheumatoid Arthritis ◽

Clinical Study ◽

Active Rheumatoid Arthritis ◽

Efficacy And Safety ◽

Double Blind ◽

Innovator Product ◽

Stable Dose ◽

Comparative Clinical Study

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A Comparative Clinical Study on Phalatrikadi Kwata and Darvyadi Kwatha in the management of Kamala w.s.r. to Jaundice

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.4.4.20 ◽

2019 ◽

Vol 4 (04) ◽

Author(s):

Kallanagouda H. ◽

S. C. Sarvi

Keyword(s):

Clinical Study ◽

Dietary Habits ◽

Clinical Signs ◽

Signs And Symptoms ◽

Mucous Membranes ◽

Comparative Clinical Study ◽

Group A ◽

Clinical Signs And Symptoms ◽

Ayurvedic Treatment ◽

Group B

Background: Jaundice (Kamala) is a yellowish pigmentation of the skin, the conjunctival membranes over the sclera (whitish of the eyes), and other mucous membranes caused by hyperbilirubinemia (increased levels of bilirubin in the blood). Today’s lifestyle with unhygienic and poor dietary habits and alcoholic habits etc. are responsible factors to promote hepatic damage which clinically reflects as Kamala Roga. The incidence of such causes resulting in Jaundice. In India it is 2.37-3.15 per 1000 population. The effect of Ayurvedic treatment was assessed in relation to improvement in overall clinical signs and symptoms. Objectives: To evaluate the effect of Phalatrikaadi Kwatha and Darvyadi Kwatha in Kamala Roga. Methodology: A comparative clinical study was conducted on Kamala for period of 15 days. The patients were divided into 2 groups. In Group A 20 patients were administered with Phalatrikadi Kwatha internally and in Group B 20 patients were administered with Darvyadi Kwatha internally. Results: Group A and Group B have shown statistically significant result. Group B treated with Darvyadi Kwatha showed better result compared with Group B treated with Phalatrikadi Kwatha.

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A COMPARATIVE CLINICAL STUDY ON THE EFFECTIVENESS OF RASONA TAILA AND GANDHARVAHASTADI ERANDA TAILA IN GRIDHRASI (SCIATICA)

International Journal of Ayurveda and Pharma Research ◽

10.47070/ijapr.v8i10.1632 ◽

2020 ◽

pp. 15-22

Author(s):

Athira.C ◽

Ajay Bhat U

Keyword(s):

Clinical Study ◽

Sciatic Nerve ◽

Statistical Tests ◽

Medical Science ◽

Signs And Symptoms ◽

Lateral Aspect ◽

Painful Condition ◽

Comparative Clinical Study ◽

Group A ◽

Group B

Gridhrasi is a Vyadhi characterized by Stambha (stiffness), Ruk (pain), Toda (pricking pain), Spandana (twitching) etc. Though it is of two types – Vataja and Vatakaphaja, Vata being the prime cause for this condition has to be tackled to gain relief. Gridhrasi, according to its signs and symptoms can be compared to sciatica in modern medical science which is a painful condition in which pain commences from the buttock and radiates into the lower extremity along its posterior or lateral aspect, more or less comprising of the area of distribution of the sciatic nerve. Thus, this study was taken up to evaluate the efficacy of Rasona taila and Gandharvahastadi eranda taila in the management of Gridhrasi (Sciatica). Methods: In the present study, 60 subjects diagnosed with Gridhrasi were randomly selected and assigned into two equal groups Group A and Group B comprising 30 subjects each. Subjects of Group A received Rasona taila 10ml orally in morning before food and subjects of Group B received Gandharvahastadi eranda taila 10 ml orally in morning before food, both for duration of 21 days. The data obtained in both the groups were recorded, tabulated and statistically analyzed using appropriate statistical methods. Results: After obtaining all the necessary data, the results were formulated by applying suitable statistical tests. Group A showed better results statistically when compared to Group B. Conclusion: Rasona taila has better effects than Gandharvahastadi eranda taila both clinically and statistically in reducing the signs and symptoms of Gridhrasi.

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A Clinical Study on the Effect of Vaitaran Basti in the Management of Amavata vis-a-vis Rheumatoid Arthritis

AYUSHDHARA ◽

10.47070/ayushdhara.v8i3.729 ◽

2021 ◽

pp. 3270-3275

Author(s):

Gulhane Harshad ◽

Bhople Sunanda ◽

Sangita Vidhale ◽

Anjali Deshmukh ◽

Anup Pande

Keyword(s):

Rheumatoid Arthritis ◽

Clinical Study ◽

Disease Activity ◽

Medical Science ◽

Treatment Protocol ◽

Signs And Symptoms ◽

International Norms ◽

T Test ◽

Challenging Problem ◽

Paired T Test

The disease Amavata described in classical Ayurvedic literature is closely mimic with Rheumatoid Arthritis (RA) in modern medical science. Amavata is the challenging problem for medical science with different treatment protocol. In this clinical study 15 patients were included having typical symptoms. All the included patients treated with Vaitaran Basti (medicated enema) to evaluate its efficacy in said disease. The patients were diagnosed on the basis of American criteria of Rheumatoid Arthritis as well as signs and symptoms mentioned in the classics. Aim: To assess the efficacy of Vaitaran Basti in the patients of Amavata, reveal the probable action of Vaitarana Basti in the management of Amavata. Materials and Methods: In the present study 15 patients of Amavata were studied. These patients were selected irrespective of sex, religion and economical status. The patients were diagnosed on the basis of American criteria of Rheumatoid Arthritis as well as signs and symptoms mentioned in the classics. American is mentioned criteria of Rheumatoid. Result: Paired t test was applied to this BT and AT scores as these grades are accepted as per international norms. It showed that administered therapy reduced degree of disease activity significantly as P < 0.001. Conclusion: It showed that administered therapy reduced degree of disease activity significantly as P < 0.001.

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