Preclinical Evaluation of Cardiovascular, Hepato-protective, Anti-cancer, Analgesic, Anti-inflammatory and Anti-oxidant Agents Using Animal Models: An Over View

Author(s):  
Dawood Shaik ◽  
Mohammad Yusufuddin
Author(s):  
Varun Garg ◽  
Barinder Kaur ◽  
Sachin Kumar Singh ◽  
Bimlesh Kumar

ABSTRACTTerminalia chebula (TC) is a unique herb having various therapeutic potentials as anti-inflammatory, antioxidant, anticancer, and digestant. It belongsto family Combretaceae. In the present review, an attempt has been made to decipher classification, chemical constituents, therapeutic uses, andpatents that have been reported for TC. Various pharmacological activities of TC that make it as potential medicine and its Ayurvedic formulationsare highlighted.Keywords: Terminalia chebula, Anti-oxidant, Anti-cancer, Ayurvedic formulations, Anti-oxidant.


2015 ◽  
Vol 25 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Seung Geun Yun ◽  
Soojung Jin ◽  
Hyun Young Jeong ◽  
Hee Jung Yun ◽  
Mi young Do ◽  
...  

Author(s):  
S Rajeshwari ◽  
SP Sevarkodiyone

Abutilon indicum is a common Indian shrub, belonging to the family Malvaceae; Also known as Mallow in english, Abutilon indicum is used as a medicinal plant. It has been extensively used as a traditional medicine as a laxative, emollient, analgesic, anti-diabetic, anti-inflammatory and blood tonic agent and also in the treatment of leprosy, urinary disease, jaundice, piles, relieving thirst, cleaning wounds and ulcers, vaginal infections, diarrhea, rheumatism, mumps, pulmonary tuberculosis, bronchitis, allergy, blood dysentery, some nervous and some ear problems. Various studies on the plant extract have been performed to confirm the anti-oxidant, anti-bacterial, analgesic, anti-inflammatory, anti-cancer, hepato-protective, immuno-modulatory and larvicidal activities of the plant. This plant is often used as a medicinal plant and is considered invasive on certain tropical islands. In traditional medicine, A. indicum is used as a aphrodisiac, demulcent, diuretic, laxative, pulmonary and sedative (leaves). The bark is astringent and diuretic; laxative, expectorant and demulcent (seeds); laxative and tonic, anti-inflammatory and anthelmintic (plant); analgesic (fixed oil); diuretic and for leprosy (roots). The plant is very much used in Siddha medicines. In fact, the bark, root, leaves, flowers and seeds are all used for medicinal purposes by Tamils. The leaves are also used to treat for pile complaints. The flowers are traditionally used to increase semen in men. The phytochemical analysis showed the Presence of Alkaloid, Saponins, Amino acid, Flavonoids, Glycosides and steroids. This plant exhibits several potential pharmacological activities. A review on the various studies on the plant has been provided for the purpose of understanding its medicinal properties.


INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (09) ◽  
pp. 15-22
Author(s):  
M. K Gadhwal ◽  
◽  
S. C Patil ◽  
P Dmello ◽  
U Joshi .

Flavonoids are a group of polyphenolic compounds with multiple biological activities including antioxidant, anti-inflammatory and anti-cancer activities. The reduced bioavailability of flavonoids, however calls for structural modifications. Quercetin possesses multiple hydroxyl groups and an ability to chelate metal ions. Transition metal complexes have shown therapeutic promises in treatment of both inflammation and cancer. The present work describes synthesis of transition metal complexes of quercetin which resulted in the synthesis of the complexes of the type M2L which were characterized by IR and proton NMR. Although anti-oxidant and anti-inflammatory activity of the quercetin-Cu complex was higher than quercetin, the anticancer activity of the quercetin-Zn complex was much higher. A mechanism of action for the same is proposed.


Author(s):  
Waseem Ahmad Ansari ◽  
Tanveer Ahamad ◽  
Mohsin Ali Khan ◽  
Zaw Ali Khan ◽  
Mohammad Faheem Khan

Abstract Luteolin (Lut) is an important plant-derived flavonoid that is widely distributed in edible herbs and vegetables. Studies on animal and human models have shown that Lut exhibits various pharmacological properties, viz. anti-inflammatory, anti-cancer, anti-oxidant, anti-apoptotic, and neurotrophic actions. The ongoing pandemic coronavirus disease-2019 (COVID-19), is a disease of the respiratory tract that consists of mild to severe symptoms of pneumonia including fever, muscle aches, sore throat, coughing, and shortness of breath. It is of particular concern in older people and patients with chronic diseases having cardiovascular and blood clotting issues or who have compromised immune. This situation prompted us to evaluate the bioactive compounds which are being used to prevent respiratory-related illness. Lut is one such compound which is used as an anti-inflammatory agent. Several studies have explained the protective nature of Lut by inhibiting virus entry and fusion with human receptors in old SARS-CoV that had emerged in 2003. Thus, regular consumption of foods having adequate amount of Lut in our diet may be helpful in inhibiting the SARS-CoV-2 infection as well and may prevent the consequent symptoms in COVID-19 patients. In present work, we have carried out the molecular docking studies of Lut with six different SARS-CoV-2 encoded key proteins. The FDA-approved drug remdesivir was also evaluated as control to compare the results. Lut showed excellent inhibitory action against papain-like proteinase, a main protease of SARS-CoV-2. Lut was also many times more active than remdesivir. Therefore, the foods which have Lut in adequate amount might be explored further for potential use against COVID-19


2013 ◽  
Vol 55 ◽  
pp. 202-208 ◽  
Author(s):  
Daycem Khlifi ◽  
Rabiaa Manel Sghaier ◽  
Sameh Amouri ◽  
Dhafer Laouini ◽  
Mokhtar Hamdi ◽  
...  

Author(s):  
Sushma M ◽  
Lahari S ◽  
Mounika A ◽  
Sailaja K.E

This study aims to extract the phytochemical constituents and in-vitro evaluation of   anti-inflammatory activity of roots of clerodendrum Indicum. Clerodendrum indicum (L.) kuntz. Commonly known as bharangi or chingari, belongs to the family verbenaceae. The plant is expectorant, stomachic, Anti-bronchitis, Anti-nociceptive, Anti-microbial, Anti-diarrheal, anti-oxidant and anti-cancer. Preliminary phytochemical screening revealed the presence of flavonoids, steroids, steroid glycosides, terpenoids etc. This study has taken with the Anti-inflammatory  activity and preliminary phytochemical screening on the clerodendrum indicum. In the present study, qualitative study of    the phytochemicals present in the sample was determined, Anti-inflammatory  activity  were carried out. On the premise of the prevailing study, the outcomes eventually concluded that the ethanolic extract of clerodendrum indicum own anti inflammatory pastime. This evaluation offers an concept that the compound of the plant clerodendrum indicum may be used as lead compound for designing robust pills which may be used for remedy of diverse diseases.


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