scholarly journals Biosynthesised Drug-Loaded Silver Nanoparticles: A Vivid Agent for Drug Delivery for Human Breast Carcinoma

2021 ◽  
Vol 14 (4) ◽  
pp. 1839-1846
Author(s):  
Pradeepa Varadharajaperumal
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Drug Carriers ◽  
The Body ◽  
Human Breast ◽  
Drug Bioavailability ◽  
Resonance Band

The use of nanoparticles as drug carriers has been investigated, and it offers various benefits, including the controlled and targeted release of loaded or associated drugs, as well as enhanced drug bioavailability. They do, however, have certain disadvantages, such as in vivo toxicity, which affects all organs, including healthy ones, and overall disease treatment improvement, which might be undetectable or limited. Silver nanoparticles are being studied more and more due to their unique physical, chemical, and optical properties, which allow them to be used in a variety of applications, including drug delivery to specific targets in the body. Given the constraints of traditional cancer treatment, such as low bioavailability and the resulting usage of high doses that produce side effects, attempts to address these challenges are essential. In this work, Biocompatible Silver nanoparticles (AgNps) loaded with tamoxifen have been prepared using the gelation process. Tamoxifen-loaded green synthesized AgNps are reported to be amorphous. The phytochemicals present in the extract of Hemionitis arifolia leaf were responsible for the reduction of silver nitrate to AgNPs. The functional groups existing in the particles were identified with FT-IR analysis. XRD analysis state that the particles were crystalline in nature and arranged in quartzite crystal. Particle size and shape were illustrated from SEM analysis and revealed that the particles were amorphous in nature. UV-visible spectrophotometer showed the band around 440nm which was identified as “surface Plasmon resonance band”. The synthesized AgNps loaded with tamoxifen were significantly effective against Human breast cancer cells. The silver nanoparticle loaded with tamoxifen was found to be inducing apoptotic signals in the selected cells. It inhibits the breast cancer cells even at the lower concentration of AgNPs and TAM-AgNPs. Further apoptotic studies (AO/EtBr and DAPI) reveal that cell death is due to the fragmentation of nuclear material of the treated cells.

scholarly journals Biomimetic synthesis of silver nanoparticles from Streptomyces atrovirens and their potential anticancer activity against human breast cancer cells

2017 ◽  
Vol 11 (8) ◽  
pp. 965-972 ◽  
Author(s):  
Ramasamy Subbaiya ◽  
Muthupandian Saravanan ◽  
Andavar Raja Priya ◽  
Konathala Ravi Shankar ◽  
Masilamani Selvam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Silver Nanoparticles ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Biomimetic Synthesis ◽  
Human Breast Cancer Cells ◽  
Human Breast

Green synthesis of anisotropic silver nanoparticles and its potential cytotoxicity in human breast cancer cells (MCF-7)

2013 ◽  
Vol 19 (5) ◽  
pp. 1600-1605 ◽  
Author(s):  
Sangiliyandi Gurunathan ◽  
Jae Woong Han ◽  
Ahmed Abdal Dayem ◽  
Vasuki Eppakayala ◽  
Jung Hyun Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Silver Nanoparticles ◽  
Green Synthesis ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

Tumor-targeted folate-decorated albumin-stabilised silver nanoparticles induce apoptosis at low concentration in human breast cancer cells

RSC Advances ◽  
2015 ◽  
Vol 5 (105) ◽  
pp. 86242-86253 ◽  
Author(s):  
Bharat Bhushan ◽  
P. Gopinath
Keyword(s):  
Breast Cancer ◽  
Silver Nanoparticles ◽  
Bovine Serum Albumin ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Ag Nps ◽  
Specific Targeting

The current study exploits the folate-mediated delivery of bovine serum albumin (BSA) stabilized Ag NPs and thereby overcomes various drawbacks associated with non-specific targeting.

scholarly journals Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells

2008 ◽  
Vol 197 (3) ◽  
pp. 503-515 ◽  
Author(s):  
D Pugazhendhi ◽  
K A Watson ◽  
S Mills ◽  
N Botting ◽  
G S Pope ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
The Body ◽  
Hydroxyl Groups ◽  
Agonist Activity ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

The phytoestrogens genistein, daidzein and the daidzein metabolite equol have been shown previously to possess oestrogen agonist activity. However, following consumption of soya diets, they are found in the body not only as aglycones but also as metabolites conjugated at their 4′- and 7-hydroxyl groups with sulphate. This paper describes the effects of monosulphation on the oestrogen agonist properties of these three phytoestrogens in MCF-7 human breast cancer cells in terms of their relative ability to compete with [3H]oestradiol for binding to oestrogen receptor (ER), to induce a stably transfected oestrogen-responsive reporter gene (ERE-CAT) and to stimulate cell growth. In no case did sulphation abolish activity. The 4′-sulphation of genistein reduced oestrogen agonist activity to a small extent in whole-cell assays but increased the relative binding affinity to ER. The 7-sulphation of genistein, and also of equol, reduced oestrogen agonist activity substantially in all assays. By contrast, the position of monosulphation of daidzein acted in an opposing manner on oestrogen agonist activity. Sulphation at the 4′-position of daidzein resulted in a modest reduction in oestrogen agonist activity but sulphation of daidzein at the 7-position resulted in an increase in oestrogen agonist activity. Molecular modelling and docking studies suggested that the inverse effects of sulphation could be explained by the binding of daidzein into the ligand-binding domain of the ER in the opposite orientation compared with genistein and equol. This is the first report of sulphation enhancing activity of an isoflavone and inverse effects of sulphation between individual phytoestrogens.

Curcumin intercalated layered double hydroxide nanohybrid as a potential drug delivery system for effective photodynamic therapy in human breast cancer cells

RSC Advances ◽  
2015 ◽  
Vol 5 (114) ◽  
pp. 93987-93994 ◽  
Author(s):  
Khatereh Khorsandi ◽  
Reza Hosseinzadeh ◽  
Mohsen Fateh
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Potential Drug ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Double Hydroxide

Curcumin intercalated layered double hydroxide nanohybrid as a potential drug delivery system has been used for effective photodynamic therapy (PDT) in human breast cancer cells.

scholarly journals Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1717
Author(s):  
Yedi Herdiana ◽  
Nasrul Wathoni ◽  
Shaharum Shamsuddin ◽  
I Made Joni ◽  
Muchtaridi Muchtaridi
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Drug Carriers ◽  
Efficient Treatment ◽  
Targeted Drug

Breast cancer remains one of the world’s most dangerous diseases because of the difficulty of finding cost-effective and specific targets for effective and efficient treatment methods. The biodegradability and biocompatibility properties of chitosan-based nanoparticles (ChNPs) have good prospects for targeted drug delivery systems. ChNPs can transfer various antitumor drugs to targeted sites via passive and active targeting pathways. The modification of ChNPs has attracted the researcher to the loading of drugs to targeted cancer cells. The objective of our review was to summarize and discuss the modification in ChNPs in delivering anticancer drugs against breast cancer cells from published papers recorded in Scopus, PubMed, and Google Scholar. In order to improve cellular uptake, drug accumulation, cytotoxicity, and selectivity, we examined different kinds of modification of ChNPs. Notably, these forms of ChNPs use the characteristics of the enhanced permeability and retention (EPR) effect as a proper parameter and different biological ligands, such as proteins, peptides, monoclonal antibodies, and small particles. In addition, as a targeted delivery system, ChNPs provided and significantly improved the delivery of drugs into specific breast cancer cells (MDA-MB-231, 4T1 cells, SK-BR-3, MCF-7, T47D). In conclusion, a promising technique is presented for increasing the efficacy, selectivity, and effectiveness of candidate drug carriers in the treatment of breast cancer.

Sign in / Sign up

Export Citation Format

Share Document