Editors Note

Impact ◽  
2018 ◽  
Vol 2018 (3) ◽  
pp. 1-1 ◽  
Author(s):  
Sonata Winchester

In this edition, covering a variety of topics across medical and dental research, as well as materials science and historical epidemiology, we see a strong representation of the value of international and interspecialty collaboration. This issue includes many such collaborative projects, including several projects that utilise developments in technology to further desired medical outcomes, combining the skills of experts in fields as varied as image and gesture interpretation research, systems and information engineering, rehabilitation engineering, medicine and occupational therapy.

1984 ◽  
Vol 1 (4) ◽  
pp. 143-154
Author(s):  
Susan Johnson Taylor ◽  
Elaine Trefler ◽  
Olunwa Nwaobi

1984 ◽  
Vol 1 (4) ◽  
pp. 143-154
Author(s):  
Susan Johnson Taylor ◽  
Elaine Trefler ◽  
Olunwa Nwaobi

1984 ◽  
Vol 1 (4) ◽  
pp. 117-129
Author(s):  
Ruth Ellen Gordon ◽  
Ken P. Kozole

2021 ◽  
Vol 21 (2) ◽  
pp. 1230-1235
Author(s):  
Jia-Yan Shen ◽  
Ting Dong ◽  
Liang Fang ◽  
Jian-Jun Ma ◽  
Li-Hong Zeng

Nanoscience is a highly comprehensive, interdisciplinary discipline based on many advanced science and technology, and has developed very rapidly in the past few decades. Nanoscience and technology has been widely used in many fields such as biomedicine, materials science, chemistry, physics, and electronic information engineering. Nanomaterials are widely used due to their many excellent properties such as quantum size effects, small size effects, surface effects, and tunneling effects, and have become hot research areas. It is very suitable as a carrier for antitumor drug molecules, which is conducive to improving drug efficacy and reducing drugs side effects. After selective functionalization, it is highly possible to achieve the loading and release of multiple drug molecules. Based on the magnetic mesoporous Fe3O4-MSNs composite nanoparticles, we have modified a series of organosilane coupling agents on its surface. The most commonly used antitumor drug (adriamycin) in clinical was selected as a model to evaluate the loading and release behavior of modified composite nanoparticles Fe3O4-MSNs on this drug. The results indicate that Fe3O4 is selectively modified after appropriate modification of the silane coupling agent. MSNs carrier can effectively regulate the adsorption and release rate of hydrophilic DOX and hydrophobic PTX, and shows a good drug control ability.


1984 ◽  
Vol 1 (4) ◽  
pp. 117-129
Author(s):  
Ruth Ellen Gordon ◽  
Ken Kozole

Author(s):  
C. Colliex ◽  
P. Trebbia

The physical foundations for the use of electron energy loss spectroscopy towards analytical purposes, seem now rather well established and have been extensively discussed through recent publications. In this brief review we intend only to mention most recent developments in this field, which became available to our knowledge. We derive also some lines of discussion to define more clearly the limits of this analytical technique in materials science problems.The spectral information carried in both low ( 0<ΔE<100eV ) and high ( >100eV ) energy regions of the loss spectrum, is capable to provide quantitative results. Spectrometers have therefore been designed to work with all kinds of electron microscopes and to cover large energy ranges for the detection of inelastically scattered electrons (for instance the L-edge of molybdenum at 2500eV has been measured by van Zuylen with primary electrons of 80 kV). It is rather easy to fix a post-specimen magnetic optics on a STEM, but Crewe has recently underlined that great care should be devoted to optimize the collecting power and the energy resolution of the whole system.


Author(s):  
Hannes Lichte ◽  
Edgar Voelkl

The object wave o(x,y) = a(x,y)exp(iφ(x,y)) at the exit face of the specimen is described by two real functions, i.e. amplitude a(x,y) and phase φ(x,y). In stead of o(x,y), however, in conventional transmission electron microscopy one records only the real intensity I(x,y) of the image wave b(x,y) loosing the image phase. In addition, referred to the object wave, b(x,y) is heavily distorted by the aberrations of the microscope giving rise to loss of resolution. Dealing with strong objects, a unique interpretation of the micrograph in terms of amplitude and phase of the object is not possible. According to Gabor, holography helps in that it records the image wave completely by both amplitude and phase. Subsequently, by means of a numerical reconstruction procedure, b(x,y) is deconvoluted from aberrations to retrieve o(x,y). Likewise, the Fourier spectrum of the object wave is at hand. Without the restrictions sketched above, the investigation of the object can be performed by different reconstruction procedures on one hologram. The holograms were taken by means of a Philips EM420-FEG with an electron biprism at 100 kV.


Author(s):  
J.C.H. Spence ◽  
J. Mayer

The Zeiss 912 is a new fully digital, side-entry, 120 Kv TEM/STEM instrument for materials science, fitted with an omega magnetic imaging energy filter. Pumping is by turbopump and ion pump. The magnetic imaging filter allows energy-filtered images or diffraction patterns to be recorded without scanning using efficient parallel (area) detection. The energy loss intensity distribution may also be displayed on the screen, and recorded by scanning it over the PMT supplied. If a CCD camera is fitted and suitable new software developed, “parallel ELS” recording results. For large fields of view, filtered images can be recorded much more efficiently than by Scanning Reflection Electron Microscopy, and the large background of inelastic scattering removed. We have therefore evaluated the 912 for REM and RHEED applications. Causes of streaking and resonance in RHEED patterns are being studied, and a more quantitative analysis of CBRED patterns may be possible. Dark field band-gap REM imaging of surface states may also be possible.


Author(s):  
Robert M. Glaeser ◽  
Bing K. Jap

The dynamical scattering effect, which can be described as the failure of the first Born approximation, is perhaps the most important factor that has prevented the widespread use of electron diffraction intensities for crystallographic structure determination. It would seem to be quite certain that dynamical effects will also interfere with structure analysis based upon electron microscope image data, whenever the dynamical effect seriously perturbs the diffracted wave. While it is normally taken for granted that the dynamical effect must be taken into consideration in materials science applications of electron microscopy, very little attention has been given to this problem in the biological sciences.


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