A Modern Domestic View of the “Black Death” and Major Epidemic Outbreaks of the Plague in the Historical Past

Research objectives: To analyze the main research trends of the last thirty years in the national historiography on the topic of the Black Death and major epidemic outbreaks of plague in the historical past. Research materials: The historiographic analysis was conducted based on both original domestic studies of the topic and those written in co-authorship with Western colleagues. To outline the main theoretical base of the topic, the author used major works on the historical theory, demography, climatology, paleogenetics, and phylogenetics of the plague bacterium Yersinia pestis. Results and novelty of the research: The analysis showed that until the 1980s, the views of Russian historians on the epidemics of the historical past were based on the study of a major German epidemiologist in the second half of nineteenth century, H. Häser. At the same time, the main directions in the research of domestic historians on the topic were developed within the framework of an order from domestic biologists and epidemiologists. This situation began to change when, in the 1980s, Russian historical research took a course towards geographical determinism. From the second half of the 1990s to the 2000s, in connection with the publications of the American Turkologist U. Schamiloglu and French historians, new topics in the field of anthropology, cultural studies, and historical demography began to be addressed in the research of domestic authors. At the same time, all theoretical considerations continued to be formed within the framework of the Marxist theory of the “crisis of the Middle Ages”. Therefore, the “Black Death” was considered exclusively as a concomitant theme attached to the main events. Only in the 2010s, in the light of the growth of joint research with Western specialists in the field of archaeology, paleogenetics, and climatology was it possible to start moving towards the development of a new theoretical and methodological basis for research on the topic in Russian historiography. The result of this process was the publication of new studies which are likely to determine the predominant course of scientific research in the field of historical epidemiology in Russia in the coming years.

Introducing activities of the Archives of Infectious Diseases History (AIDH) project: Historical epidemiology

The AIDH is a project as a historical epidemiology. The AIDH aims to collect, maintain, and manage past epidemiological materials and to offer these materials to persons who are interested in the history and in the fields of tropical medicine and global health. In this paper, we introduce our purpose and activities and show a hypothesis about lymphatic filariasis with Brugia malayi in Japan as a case of historical epidemiology. We hope to build fruitful ties between historians and scholars of tropical medicine and global health workers through an interdisciplinary approach to the history of control of infectious diseases.

Historical epidemiology and global health history

The subdiscipline of historical epidemiology holds the promise of creating a more robust and more nuanced foundation for global public health decision-making by deepening the empirical record from which we draw lessons about past interventions. This essay draws upon historical epidemiological research on three global public health campaigns to illustrate this promise: the Rockefeller Foundation’s efforts to control hookworm disease (1909-c.1930), the World Health Organization’s pilot projects for malaria eradication in tropical Africa (1950s-1960s), and the international efforts to shut down the transmission of Ebola virus disease during outbreaks in tropical Africa (1974-2019).

‘Seq & Destroy’: the full genome sequencing of archived wild type and vaccine rinderpest virus isolates prior to their destruction

Rinderpest, a once much feared livestock disease, was declared eradicated in 2011, however virus-containing material is still held in laboratories worldwide. Prior to the destruction of our institute’s stocks, we determined the full genome sequence of the distinct samples of rinderpest virus (RPV) in our repository. This data would decipher the historical epidemiology of RPV and allow for recovery of the virus should the need arise. For each sample (n=123), sequencing libraries were prepared using either transposon-based fragmentation of cDNA (Nextera XT DNA Library Prep kit) or single primer isothermal amplification (Trio RNA-Seq kit) and sequenced on the Illumina MiSeq. Regions of low or no coverage were re-sequenced using a Sanger sequencing approach. Examination of the sequences of RPV isolates has shown that the African isolates form a single disparate clade, rather than two separate clades as was previously believed. We have also identified two groups of goat-passaged viruses which have acquired an extra 6 bases in the long untranslated region between the matrix and fusion protein coding sequences, and a group of African isolates where translation of the fusion protein begins from a non-standard start codon (AUA). In addition, the viruses that were force-passaged through alternate hosts such as rabbits or goats, appear to diverge from the clades that represent viruses which were maintained in the wild. Our unique set of sequence data will be invaluable for forensic epidemiology investigations in the event of an unforeseen outbreak and aid in the understanding of the evolution of related morbilliviruses.

Spatiotemporal Distribution of Malaria in Spain in a Global Change Context

Malaria is one of the most cited vector-borne infectious diseases by climate change expert panels. Malaria vectors often need water sheets or wetlands to complete the disease life cycle. The current context of population mobility and global change requires detailed monitoring and surveillance of malaria in all countries. This study analysed the spatiotemporal distribution of death and illness cases caused by autochthonous and imported malaria in Spain during the 20th and 21st centuries using multidisciplinary sources, Geographic Information System (GIS) and geovisualisation. The results obtained reveal that, in the 20th and 21st centuries, malaria has not had a homogeneous spatial distribution. Between 1916 and 1930, 77% of deaths from autochthonous malaria were concentrated in only 20% of Spanish provinces; in 1932, 88% of patients treated in anti-malarial dispensaries were concentrated in these same provinces. These last data reveal the huge potential that anti-malarial dispensaries could have as a tool to reconstruct historical epidemiology. Spanish autochthonous malaria has presented epidemic upsurge episodes, especially those of 1917–1922 and 1939–1944, influenced by armed conflict, population movement and damaged health and hygiene conditions. Although meteorological variables have not played a key role in these epidemic episodes, they contributed by providing suitable conditions for their intensification. After the eradication of autochthonous malaria in 1961, imported malaria cases began to be detected in 1973, reaching more than 700 cases per year at the end of the second decade of the 21st century. Therefore, consistent and detailed historical studies are necessary to better understand the drivers that have led to the decline and elimination of malaria in Europe and other temperate countries.

Disease and Epidemiology of Humans and Animals: Methods

Research in the field of historical epidemiology involves a multidisciplinary approach that integrates evidence from the biomedical and public health sciences with other sources for historical analysis. Its principal goal is the understanding of the distribution of disease over time and space and the ways in which disease control efforts have had an impact on disease transmission. Based in part on microbiological data and analysis, the historical burdens of infectious disease for human beings and domesticated livestock in early tropical Africa appear to have been high relative to other world regions. Although Africans developed indigenous treatments that provided relief for many human diseases (and, in the case of smallpox, used variolation with smallpox matter to induce immunity), it was only in the 20th century that major scientific advances in disease control and treatment through the use of antibiotics and vaccines began to substantially reduce the overall burden of human and animal infectious disease. The advances in Western biomedicine did not displace African systems of indigenous medicine, and in most African contexts, different systems of medicine coexist.

Editors Note

In this edition, covering a variety of topics across medical and dental research, as well as materials science and historical epidemiology, we see a strong representation of the value of international and interspecialty collaboration. This issue includes many such collaborative projects, including several projects that utilise developments in technology to further desired medical outcomes, combining the skills of experts in fields as varied as image and gesture interpretation research, systems and information engineering, rehabilitation engineering, medicine and occupational therapy.