Optimizing trans-arterial drug delivery using mono-disperse emulsion

Impact ◽  
2019 ◽  
Vol 2019 (8) ◽  
pp. 9-11
Author(s):  
Daisuke Yasui
Keyword(s):  
Anticancer Agents ◽  
Anticancer Agent ◽  
Transcatheter Arterial Chemoembolization ◽  
Human Cancer ◽  
Standard Of Care ◽  
Tumor Control ◽  
Metastatic Liver Cancer ◽  
Curative Therapy ◽  
Emulsion Droplets ◽  
Arterial Chemoembolization

Hepatocellular carcinoma is one of the most common human cancer and is the 5th cause of mortality in men and the 7th in female. Surgical resection and tumor ablation (radiofrequency or microwave) are curative therapy; however, some patients are not indicated to these treatments, mainly due to large number or size of the lesions. Transcatheter arterial chemoembolization is a standard of care for these patients. In this treatment, mixture of various anticancer agent (Doxorubicin, Cisplatin, Miriplatin) and lipophilic contrast media (Lipiodol) is administered via catheter inserted into tumor feeding arteries, followed by embolization. Tumor control can be obtained in 50-90 % of the patients and there is a room for improvement. One major cause of poor tumor control is uneven large-sized emulsion droplets, which are now used in clinical practice. The aim of this project is to improve accumulation of anticancer agents/lipiodol in the tumor by using even small-sized emulsion (mono-dispersed emulsion) which is obtained by utilizing cutting-edge technology called 'membrane emulsification'. The application can be also widened to metastatic liver cancer.

scholarly journals Immunocytes as a Biocarrier to Delivery Therapeutic and Imaging Contrast Agents to Tumors

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Jinhyang Choi ◽  
Ha-Na Woo ◽  
Eun Jin Ju ◽  
Joohee Jung ◽  
Hye-Kyung Chung ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Ionizing Radiation ◽  
Mouse Model ◽  
Cancer Treatment ◽  
Anticancer Agents ◽  
Anticancer Agent ◽  
Human Cancer ◽  
Genetic Alterations ◽  
Therapeutic Effects ◽  
Ionizing Radiation Exposure

Radiotherapy for cancer treatment has been used for primary or adjuvant treatment in many types of cancer, and approximately half of all cancer patients are undergoing radiation. However, ionizing radiation exposure induces genetic alterations in cancer cells and results in recruitment of monocytes/macrophages by triggering signals released from these cells. Using this characteristic of monocytes/macrophages, we have attempted to develop a biocarrier loading radiosensitizing anticancer agents that can lead to enhance the therapeutic effect of radiation in cancer treatment. The aim of this study is to demonstrate the proof of this concept. THP-1 labeled with Qdot 800 or iron oxide (IO) effectively migrated into tumors of subcutaneous mouse model and increased recruitment after ionizing radiation. Functionalized liposomes carrying a radiosensitizing anticancer agent, doxorubicin, are successfully loaded in THP-1 (THP-1-LP-Dox) with reduced cytotoxicity, and THP-1-LP-Dox also was observed in tumors after intravenous administration. Here, we report that monocytes/macrophages as a biocarrier can be used as a selective tool for amplification of the therapeutic effects on radiotherapy for human cancer treatment.

scholarly journals Liver abscesses after transcatheter arterial embolization

2019 ◽  
Vol 47 (3) ◽  
pp. 1124-1130 ◽  
Author(s):  
Muhammet Arslan ◽  
Serkan Degirmencioglu
Keyword(s):  
Risk Factors ◽  
Medical Records ◽  
Transcatheter Arterial Chemoembolization ◽  
Arterial Embolization ◽  
Metastatic Liver Cancer ◽  
Radiological Findings ◽  
Bilioenteric Anastomosis ◽  
Liver Abscesses ◽  
Metastatic Liver ◽  
Arterial Chemoembolization

Objective This study aimed to evaluate the clinical features, radiological findings, risk factors, and management of liver abscesses following transcatheter arterial chemoembolization (TACE) therapy in patients with primary and metastatic liver cancer. Methods The medical records of 163 patients who were treated with TACE in our hospital for a total of 313 times between January 2012 and January 2018 were reviewed. The incidence rate of patients who developed liver abscesses after undergoing treatment, the computed tomography findings of the abscesses, predisposing risk factors, and the method of treatment were evaluated. Results Formation of liver abscesses was observed after treatment in four of the 163 (2.4%) patients and in four (1.3%) of the 313 chemoembolization procedures. Additionally, bilioenteric anastomosis was found in two patients and diabetes mellitus in two patients. Conclusion Formation of liver abscesses after TACE is a rare, but serious, complication. Physicians should be aware of the predisposing risk factors of TACE because of the possibility of death.

Phase II study of segmental transcatheter arterial chemoembolization using ethiodized oil mixed with cisplatin powder for unresectable hepatocellular carcinoma.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 292-292
Author(s):  
H. Anai ◽  
T. Tanaka ◽  
H. Nishiofuku ◽  
S. Sueyoshi ◽  
K. Yamamoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Phase Ii ◽  
Transcatheter Arterial Chemoembolization ◽  
Phase Ii Study ◽  
Gelatin Sponge ◽  
Tumor Control ◽  
Transaminase Elevation ◽  
Ethiodized Oil ◽  
Cisplatin Powder ◽  
Arterial Chemoembolization

292 Background: Conventional transcatheter arterial chemoembolization (TACE) using with ethiodized oil mixed with epirubicin or doxorubicin hydrochloride mainly has been widely adapted for intermediate-stage hepatocellular carcinoma (HCC). However, cisplatin has stronger effect for HCC than epirubicin and in the recent years cisplatin powder was commercially available in Japan and then we can use cisplatin powder mixed with ethiodized oil for HCC. We conducted a phase II study to assess the safety and efficacy of segmental or subsegmental (Seg/Subseg) TACE using a suspension of cisplatin powder mixed with ethiodized oil for unresectable HCC. Methods: Twenty patients with single-nodule HCC that was not indicated for surgical treatment or local ablation therapy were enrolled in this study. Seg/Subseg-TACE was performed by using a 2-F tip microcatheter at a distal portion of the subsegmental artery supplying the tumor. Subsequently, the feeding artery was embolized with gelatin sponge particles. The suspension was prepared by mixing 100 mg of cisplatin powder with 10 ml of ethiodized oil. Primary endpoint of this phase II trial was 2-year local disease free survival (DFS); secondary endpoints evaluated were the safety, time to progression (TTP), and 2-year overall survival (OS) rate. Results: A total of 20 patients (male 15, female 5; mean age 72.4, range 62-83; Child Pugh's A 20) were treated single nodule HCC with Seg/subseg TACE. Median tumor size was 2.6cm (range1.2-5.0cm). The 2-year local DFS was 63.2 %. The following grade 3 or 4 toxicities were observed: platelets reduction 5%, aspartate transaminase elevation 55%, alanine transaminase elevation 40% and alkaline phosphatase elevation 5%. The median TTP was 17.6 months (95%CI, 5.25 to 29.9) and the 2-year OS rate was 94.7%. Conclusions: This phase II study demonstrates that segmental or subsegmental transcatheter arterial chemoembolization using a suspension of cisplatin powder mixed with ethiodized oil is well tolerable, and may achieve significant local tumor control and prolong survival. Further clinical trials are warranted. No significant financial relationships to disclose.

Carboplatin as an Anticancer Agent for Transcatheter Arterial Chemoembolization in Patients with Hepatocellular Carcinoma

Oncology ◽  
1997 ◽  
Vol 54 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Fumihiko Yamashita ◽  
Masatoshi Tanaka ◽  
Eiji Andou ◽  
Shigeru Yutani ◽  
Osamu Kato ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Anticancer Agent ◽  
Transcatheter Arterial Chemoembolization ◽  
Arterial Chemoembolization

Radial Artery Approach for Transcatheter Arterial Chemoembolization in Patients with Hepatocellular Carcinoma

2002 ◽  
Vol 46 (3) ◽  
pp. 229
Author(s):  
Seung Hun Ryu ◽  
Hyung Jin Shim ◽  
Byung Kook Kwak ◽  
Gi Hyun Kim ◽  
Hwa Yeon Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radial Artery ◽  
Transcatheter Arterial Chemoembolization ◽  
Arterial Chemoembolization
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