scholarly journals Effects of ADAM10 and ADAM17 Inhibitors on Natural Killer Cell Expansion and Antibody-dependent Cellular Cytotoxicity Against Breast Cancer Cells In Vitro

2017 ◽  
Vol 37 (10) ◽  
Keyword(s):  
Breast Cancer ◽  
Natural Killer Cell ◽  
Cancer Cells ◽  
Natural Killer ◽  
Cell Expansion ◽  
Breast Cancer Cells ◽  
Killer Cell ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity

scholarly journals Resveratrol promotes MICA/B expression and natural killer cell lysis of breast cancer cells by suppressing c-Myc/miR-17 pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (39) ◽  
pp. 65743-65758 ◽  
Author(s):  
Jie Pan ◽  
Jiaying Shen ◽  
Wengong Si ◽  
Chengyong Du ◽  
Danni Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Natural Killer Cell ◽  
Cancer Cells ◽  
Natural Killer ◽  
Breast Cancer Cells ◽  
Killer Cell ◽  
Cell Lysis ◽  
Natural Killer Cell Lysis

scholarly journals Malignant monoblasts can function as effector cells in natural killer cell and antibody-dependent cellular cytotoxicity assays

Blood ◽  
1981 ◽  
Vol 57 (5) ◽  
pp. 972-974 ◽  
Author(s):  
P Hokland ◽  
M Hokland ◽  
J Ellegaard
Keyword(s):  
Natural Killer ◽  
Killer Cell ◽  
Present Knowledge ◽  
In Vitro Cultures ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Effector Cells ◽  
Cytotoxicity Assays ◽  
Acute Monoblastic Leukemia

Abstract This is the first report describing natural killer (NK) and antibody- dependent cellular cytotoxicity (ADCC) of malignant monoblasts. Pure acute monoblastic leukemia was diagnosed in bone marrow aspirations from two patients by use of conventional cytochemical methods as well as multiple immunologic techniques including detection of ALL antigens and terminal transferase. The malignant cells were subsequently found to be potent effectors in NK and ADCC assays. Addition of partially purified alpha-interferon to the in vitro cultures was found to have an enhancing effect on NK activity, whereas no modulation was seen in ADCC. These findings are discussed in the light of our present knowledge of lymphoid NK cells.

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