Potential Risk Factors Influencing the Formation of Postoperative Seroma After Breast Surgery – A Prospective Study

2021 ◽  
Vol 41 (2) ◽  
pp. 859-867
Author(s):  
JULIA UNGER ◽  
RICO RUTKOWSKI ◽  
THOMAS KOHLMANN ◽  
STEFAN PAEPKE ◽  
MAREK ZYGMUNT ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prospective Study ◽  
Potential Risk ◽  
Breast Surgery ◽  
Factors Influencing ◽  
Potential Risk Factors ◽  
A Prospective Study

scholarly journals Lipid profile as a predictor of Neuropathy: The Sheffield Prospective Diabetes Study

2018 ◽  
Vol 2 (2) ◽  
pp. 47-51
Author(s):  
Satyan Rajbhandari ◽  
Fahad Syed Hamid ◽  
Nigel Harris ◽  
Solomon Tesfaye
Keyword(s):  
Risk Factors ◽  
Prospective Study ◽  
Epidemiological Studies ◽  
Base Line ◽  
Perception Threshold ◽  
Reduction Strategies ◽  
Potential Risk Factors ◽  
A Prospective Study

Background : Despite being a very common complication, the aetiology and potential risk factors of diabetic neuropathy (DN) have not been clearly determined in a prospective study. Aims: The aim of Sheffield Prospective Diabetes Study was to identify the abnormalities of physiological, biochemical, haemorrhelogical and cellular function for complications of diabetes in type 1 diabetes. Materials and Methods: 66 newly diagnosed type 1 diabetic subjects (mean age 31 ± 9 (SD) duration (3 years ± 2) were identified and followed for 9 years. They had detailed neurological assessment (symptoms and signs score, nerve conduction, vibration perception threshold, warm thermal discrimination threshold and autonomic function tests) and blood samples taken for detail biochemical and haemorrheological analysis at base line and at follow up. Results: At the 9 years follow up, 51 subjects were studied of whom 18 were found to have DN using Dyck’s criteria. As expected subjects with DN had significantly higher (p <0.01) mean HbA1 over 9 years of follow up (11.8% vs 9.8%), but it was not significantly different at base line (10.2% vs 8.9%; p= 0.37). In addition, total cholesterol and LDL cholesterol at baseline were found to be risk factors for the development of neuropathy (5.9 vs 4.7 mmol; p=0.01 and 3.7 vs 2.8 mmol; p=0.03 respectively). Conclusions: This prospective study confirms the findings of recent large epidemiological studies linking cardiovascular risk factors to the development of DN, and perhaps suggest a vascular aetiology for DN. Improvement of potentially modifiable risk factors for neuropathy may be useful for the development of risk reduction strategies.

scholarly journals Longitudinal changes in the antecedent and early manifest course of bipolar disorder—A narrative review of prospective studies

2017 ◽  
Vol 51 (5) ◽  
pp. 509-523 ◽  
Author(s):  
Andrea Pfennig ◽  
Karolina Leopold ◽  
Philipp Ritter ◽  
Anne Böhme ◽  
Emanuel Severus ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Prospective Study ◽  
Potential Risk ◽  
Prospective Studies ◽  
Bipolar Disorders ◽  
Childhood Anxiety ◽  
Narrative Review ◽  
Character Traits ◽  
Potential Risk Factors

Objective: Prospective study designs ideally allow patients to be followed from the first manifestations of the illness or even from an at-risk stage. It can thus provide data on the predictive value of changes in clinical symptomatology, cognition or further biological markers to broaden our understanding of the etiopathology and symptomatic trajectory of bipolar disorders. The scope of this narrative review is to summarize evidence from prospectively collected data on psychopathological and other clinical and biological changes in the early developmental course of bipolar disorders. Methods: The narrative review was based on a literature search conducted in February 2016 within the PubMed library for prospective study data of persons in antecedent and early manifest stages of manifest bipolar disorder published within the last 15 years. Results: A total of 19 prospective studies were included. Regarding psychopathological features; personality, temperament and character traits as well as changes in sleep and circadian rhythm, the evidence suggests that risk factors for the development of bipolar disorder can already be described and should be studied further to understand their interaction, mediation with other factors and timing in the developmental process of bipolar disorder. Apart from the positive family history, childhood anxiety, sleep problems, subthreshold (hypo)manic symptoms and certain character traits/emotionality should be identified and monitored already in clinical practice as their presence likely increases risk of bipolar disorder. Up to date no substantiated evidence was found from prospective studies addressing cognitive features, life events, immunological parameters and morphological central nervous system changes as potential risk factors for bipolar disorder. Conclusion: For an improved understanding of episodic disorders, longitudinal data collection is essential. Since the etiology of bipolar disorders is complex, a number of potential risk factors have been proposed. Prospective studies addressing this spectrum and resilience factors are critical and will be best conducted within multi-site research networks or initiatives.

Premature Arterial Disease Associated with Familial Antithrombin III Deficiency

1990 ◽  
Vol 63 (01) ◽  
pp. 013-015 ◽  
Author(s):  
E J Johnson ◽  
C R M Prentice ◽  
L A Parapia
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Potential Risk ◽  
Antithrombin Iii ◽  
Arterial Disease ◽  
Coagulation System ◽  
Early Age ◽  
Arterial Thromboembolism ◽  
Potential Risk Factors ◽  
Antithrombin Iii Deficiency

SummaryAntithrombin III (ATIII) deficiency is one of the few known abnormalities of the coagulation system known to predispose to venous thromboembolism but its relation to arterial disease is not established. We describe two related patients with this disorder, both of whom suffered arterial thrombotic events, at an early age. Both patients had other potential risk factors, though these would normally be considered unlikely to lead to such catastrophic events at such an age. Thrombosis due to ATIII deficiency is potentially preventable, and this diagnosis should be sought more frequently in patients with arterial thromboembolism, particularly if occurring at a young age. In addition, in patients with known ATIII deficiency, other risk factors for arterial disease should be eliminated, if possible. In particular, these patients should be counselled against smoking.

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