Post-Mortem Comparison of the Incidence and the Distribution of Cerebrovascular Lesions Using Additional 7.0-Tesla Magnetic Resonance Imaging in Cognitive Normal Young, Middle-Aged, and Elderly Persons

Neuropathological examination of post-mortem brains of patients with dementia due to neurodegenerative and cerebrovascular changes remains important, as the family wants to be sure about the clinical diagnosis and the risk of a hereditary disease. 7.0-tesla magnetic resonance imaging (MRI) can be applied as an additional tool to examine post-mortem brains of patients with neurodegenerative and cerebrovasular diseases. It allows examination of serial coronal sections of a cerebral hemisphere and horizontal sections of brainstem and cerebellum and comparison with the neuropathological lesions. Post-mortem MRI can show the degree and the distribution of the cerebral atrophy. Additional small cerebrovascular lesions can be quantified. The degree of iron load, not due to microbleeds, can be evaluated in different basal ganglia and brainstem structures. Three to six serial sections of a cerebral hemisphere and one section of brainstem and cerebellum allow the evaluation of the most important brain changes and to select the small samples to be used for histological diagnostic purposes. These correlation studies are extremely important for the future, when more 7.0-tesla MRI machines will be available forin vivoclinical-radiological diagnosis. This article is a review of post-mortem MRI data in the brains of patients with neurodegenerative and vascular dementias.

Download Full-text

Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathy

10.21926/obm.geriatr.2004142 ◽

2020 ◽

Vol 4 (4) ◽

Author(s):

Jacques De Reuck ◽

◽

Florent Auger ◽

Nicolas Durieux ◽

Claude-Alain Maurage ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Cerebral Amyloid Angiopathy ◽

Amyloid Angiopathy ◽

Post Mortem ◽

Resonance Imaging ◽

Cerebrovascular Lesions ◽

Mri Sequences ◽

Cerebral Amyloid ◽

Magnetic Resonance Imaging Mri

Purpose: The influence of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD) remains unexplored. The present post-mortem study investigated possible differences in the degree of hippocampal atrophy (HA) between AD patients with and without CAA using 7.0-tesla magnetic resonance imaging (MRI). Also, the incidence of the hippocampal cortical micro-infarcts (HCoMIs) and hippocampal cortical micro-bleeds (HCoMBs) is compared to those in the neocortex. Methods: The examined post-mortem brains included 30 AD-CAA cases and 20 AD without CAA cases. The samples of the hippocampus were evaluated on the most representative coronal section with T2 and T2* MRI sequences. The average degree of HA was determined in both groups. The incidences of HCoMIs and HCoMBs, along with the frequency of CoMIs and CoMBs in the neocortex were compared in both groups: AD-with CAA and AD without CAA cases. Results: No significant differences were observed in the degree of HA and the incidence of hippocampal micro-infarcts (HMIs) and hippocampal micro-bleeds (HMBs) between the AD-CAA and the AD brains in contrast to the higher incidence of these cerebrovascular lesions in the neocortex of AD-CAA brains. The incidence of CoMIs and CoMBs in the neocortex showed similarity to that in the hippocampus of AD patients without CAA. Conclusions: CAA does not influence the degree of HA and the incidence of micro-infarcts (MIs) and micro-bleeds (MBs) in the hippocampus, in contrast to the high contribution of the latter with CAA in the neocortex. The hippocampus seems to be more spared from cerebrovascular involvement than the other parts of the brain.

Download Full-text

The Incidence of Cerebrovascular Lesions in Vascular Dementia Due to Arteriosclerosis and Due to Cerebral Amyloid Angiopathy: A Post-Mortem Neuropathological Study With 7.0-Tesla Magnetic Resonance Imaging

Acta Scientific Neurology ◽

10.31080/asne.2020.03.0163 ◽

2020 ◽

Vol 3 (3) ◽

pp. 01-06

Author(s):

Jacques De Reuck ◽

Florent Auger ◽

Nicolas Durieux ◽

Claude Alain Maurage ◽

Vincent Deramecourt ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Vascular Dementia ◽

Cerebral Amyloid Angiopathy ◽

Amyloid Angiopathy ◽

Post Mortem ◽

Resonance Imaging ◽

Cerebrovascular Lesions ◽

Cerebral Amyloid

Download Full-text

The prevalence of periarticular lesions detected on magnetic resonance imaging in middle-aged and elderly persons: a cross-sectional study

BMC Musculoskeletal Disorders ◽

10.1186/s12891-016-1035-6 ◽

2016 ◽

Vol 17 (1) ◽

Cited By ~ 3

Author(s):

In Je Kim ◽

Dong Hyun Kim ◽

Yeoung Wook Song ◽

Ali Guermazi ◽

Michel D. Crema ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Cross Sectional Study ◽

Elderly Persons ◽

Sectional Study ◽

Resonance Imaging ◽

Middle Aged ◽

Cross Sectional

Download Full-text

Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia: a post-mortem 7-tesla magnetic resonance imaging study with neuropathological correlates

Folia Neuropathologica ◽

10.5114/fn.2017.66711 ◽

2017 ◽

Vol 1 ◽

pp. 31-37 ◽

Cited By ~ 4

Author(s):

Jacques De Reuck ◽

Florent Auger ◽

Nicolas Durieux ◽

Vincent Deramecourt ◽

Claude-Alain Maurage ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Imaging Study ◽

7 Tesla ◽

Post Mortem ◽

Magnetic Resonance Imaging Study ◽

Resonance Imaging ◽

Mixed Dementia ◽

Cerebrovascular Lesions

Download Full-text

Post-Mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Progressive Supranuclear Palsy with and without Cerebral Amyloid Angiopathy

NeuroSci ◽

10.3390/neurosci1020011 ◽

2020 ◽

Vol 1 (2) ◽

pp. 115-120

Author(s):

Jacques De Reuck ◽

Florent Auger ◽

Nicolas Durieux ◽

Claude-Alain Maurage ◽

Vincent Deramecourt ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Progressive Supranuclear Palsy ◽

Cerebral Amyloid Angiopathy ◽

Amyloid Angiopathy ◽

Post Mortem ◽

Resonance Imaging ◽

Cerebral Amyloid ◽

Magnetic Resonance Imaging Mri ◽

Neuropathological Examination

Introduction and Purpose: Cerebral amyloid angiopathy (CAA) can be observed in patients with progressive supranuclear palsy (PSP), though to a lesser degree than in Alzheimer’s disease. The present post-mortem 7.0-tesla magnetic resonance imaging (MRI) evaluates whether CAA has an influence on the degree of hippocampal atrophy (HA) and on the incidence of associated micro-infarcts (HMIs) and cortical micro-bleeds (HMBs). Material and Methods: Eight brains with PSP-CAA were compared to 20 PSP brains without CAA. In addition to the neuropathological examination, the hippocampus was evaluated on the most representative coronal section with T2 and T2*-weighted MRI sequences. The average degree of HA was determined in both groups. The incidence of HMIs and HMBs was also compared as well as the frequency of cortical micro-infarcts (CoMIs) and cortical micro-bleeds (CoMBs) in the hemispheric neocortex. Results: The neuropathological examination showed a higher incidence of lacunar infarcts in the PSP-CAA brains compared to the PSP ones. With magnetic resonance imaging (MRI), the severity of HA and the incidence of HMIs and HMBs was similar between both groups. Additionally, the frequency of CoMIs and CoMBs in the neocortex was comparable. Conclusions: The association of CAA in PSP brains has no influence on the degree of HA and on the incidence of the small cerebrovascular lesions in the hippocampus as well as in the neocortex.

Download Full-text

The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease

Neuroscience ◽

10.1016/s0306-4522(99)00476-5 ◽

1999 ◽

Vol 95 (3) ◽

pp. 721-725 ◽

Cited By ~ 238

Author(s):

M. Bobinski ◽

M.J. de Leon ◽

J. Wegiel ◽

S. DeSanti ◽

A. Convit ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Magnetic Resonance ◽

Hippocampal Volume ◽

Post Mortem ◽

Resonance Imaging ◽

Histological Validation

Download Full-text

Visualisation of fetal meconium on post-mortem magnetic resonance imaging scans: a retrospective observational study

Acta Radiologica Open ◽

10.1177/2058460120970541 ◽

2020 ◽

Vol 9 (11) ◽

pp. 205846012097054

Author(s):

Georgia Hyde ◽

Andrew Fry ◽

Ashok Raghavan ◽

Elspeth Whitby

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Signal Intensity ◽

Interrater Reliability ◽

Hepatic Flexure ◽

Radiology Department ◽

High Signal ◽

Post Mortem ◽

Resonance Imaging ◽

Tertiary Referral Centre

Background Less invasive techniques for fetal post-mortems are increasingly used to correlate with parental wishes. With the use of post-mortem magnetic resonance imaging (MRI), normal appearance of the organs must be established. Purpose To investigate the after death appearance of the fetal meconium throughout gestation using the hyperintense appearance of meconium on T1 weighted MRI. Material and Methods This was a retrospective study that took place in a tertiary referral centre radiology department. Sixty-two fetal body post-mortem MRI scans (January 2014 to May 2018) between 12 and 41 weeks gestation were reviewed. Signal intensity of meconium at the rectum, sigmoid colon, splenic flexure and hepatic flexure was evaluated and correlated with gestational age. Interrater reliability was calculated. Results Meconium did not consistently have high signal intensity on T1 scans and was not always obvious. Rectal meconium had the highest intensity, and the more proximal the bowel the lower the intensity. The meconium had higher intensity at earlier gestations. Interrater reliability for rectal meconium gradings was excellent. Conclusion This study provides the first published primary research on the appearance of fetal meconium on post-mortem MRI. Overall, results were variable and suggest an alteration of bowel contents after death, but further investigation is needed to effectively inform practice.

Download Full-text