“Ô DIDE” an application designed for patients suffering from co-occurring substance use and borderline personality disorder to facilitate the care observance (Preprint)

2020 ◽  
Author(s):  
Juliette Salles ◽  
Antoine Stocker ◽  
Nicolas Navarro ◽  
Laurent Schmitt

UNSTRUCTURED Background: Substance Use Disorders (SUD) are frequently associated with other mental disorders, especially Borderline Personality Disorder, thus defining co-occurring substance use and mental disorders with borderline personality disorders (COD-BPD). Due to their personality disorder, patients with COD-BPD often present cognitive schemas that lead to care attrition and mistrust towards care. The comprehension of the construction and the treatment of those cognitive schemas were most notably modelized by the attachment theory that differentiates between a secure attachment style that is established through a sensitive, supportive, and caregiving environment and insecure attachment styles that are the result of an inconsistent, insensitive, or dismissive attachment figure. Considering this theory within SUD management, the goal of the care intervention is to help the patient to switch from an insecure to a secure attachment style in order to reduce the use of dysfunctional coping strategies involving substance use. Indeed, the establishment of a confident relation between the patient and the care team participate into building a secure attachment towards care that could secondly be generalized in other situations. However, the development of a secure relationship in the care demands an important availability of the healthcare team, allowing for frequent interactions at all times, including at night and during days off, in order to build an adequate secure base. We consider that Electronic health (eHealth) and mobile health (mHealth) could also help achieve this goal by improving healthcare worker’s availability. We thus designed an application for patients with COD-BPD that aims to help the caregivers maintaining a link with the patient in order to facilitate confidence in the relationship, help install a secure attachment and favorize care observance. Methods : The application, called Ô DIDE for Digital Interaction for Detoxification Engagement, consists in i) a patient dedicated interface developed according to psychopathological considerations (attachment theory) as well as neurobiological findings (dedicated craving or relapse report system adapted to the alteration of the circadian rhythm, implementation of rewards and motivational messages to reinforce the reward system and the use of declarative memory systems by creating content related to the care), ii) a clinician dedicated interface which has been designed as a decision-making support system for care. Results: The application is currently under development, and is scheduled for the end of 2020. We will be using patients’ feedback during development to ensure the final product is as close as possible to their needs and to maximize their engagement. After the development we will evaluate the application effect on care by using a single case experimental design (SCED) method. We will use a multiple baseline design and will monitor various aspects of the use of the application (e.g. connections, report of relapses, communication with the healthcare team). Conclusion: We designed an application by using pathopsychological as well as neurobiological models and by including patients’ feedback throughout the development process. We intend to evaluate the use of this application by using the SCED method.

Author(s):  
Christian E. Deuter ◽  
Moritz Duesenberg ◽  
Julian Hellmann-Regen ◽  
Sophie Metz ◽  
Stefan Roepke ◽  
...  

Abstract Background The gonadal hormone testosterone not only regulates sexual behavior but is also involved in social behavior and cognition in both sexes. Changes in testosterone secretion in response to stress have been reported. In addition, stress associated mental disorders such as borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) are characterized by alterations in basal testosterone metabolism. However, testosterone changes to stress have not been investigated in mental disorders such as BPD and PTSD so far. Methods In the study described, we investigated testosterone reactivity to an acute psychosocial stressor, the Trier Social Stress Test (TSST). Our sample consisted of young adult women with BPD (n = 28), PTSD (n = 22) or both disorders (n = 22), and healthy control (n = 51). Based on previous studies on basal testosterone secretion in these disorders, we expected the stress-associated testosterone reactivity to be higher in the BPD group and lower in the PTSD group, when compared to the healthy control group. Results The study could demonstrate an increase in testosterone after acute stress exposure across all groups and independent of BPD or PTSD status. Different possible explanations for the absence of a group effect are discussed. Conclusions From the results of this study, we conclude that stress-related changes in testosterone release are not affected by BPD or PTSD status in a female patient population. This study expands the knowledge about changes in gonadal hormones and stress reactivity in these disorders.


Author(s):  
Timothy J. Trull ◽  
Lindsey K. Freeman ◽  
Tayler J. Vebares ◽  
Alexandria M. Choate ◽  
Ashley C. Helle ◽  
...  

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