3-T MRI: Usefulness for Evaluating Primary Lung Cancer and Small Nodules in Lobes Not Containing Primary Tumors

2007 ◽  
Vol 189 (2) ◽  
pp. 386-392 ◽  
Author(s):  
Chin A Yi ◽  
Tae Yeon Jeon ◽  
Kyung Soo Lee ◽  
Jung Hee Lee ◽  
Joon Beom Seo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Primary Tumors

scholarly journals Expression of Five Target Proteins Related to Human Cytomegalovirus Infection in Brain Metastases of Lung Cancer

2021 ◽  
Author(s):  
Jie Wu ◽  
Haifeng Zhao ◽  
Ke Yan ◽  
Xiangtong Xie ◽  
Donghua Gu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Human Cytomegalovirus ◽  
Hcmv Infection ◽  
Primary Lung Cancer ◽  
Molecular Therapy ◽  
Early Gene ◽  
Primary Tumors ◽  
Target Molecules

Abstract Background: The links between brain metastases of lung cancer and human cytomegalovirus (HCMV) infection have been controversial for a long time. This study aims to explore the links between brain metastases of lung cancer and HCMV infection from the perspective of expression and detection of HCMV immediate early gene (IE), guanine nucleotide-binding protein 4 (GBP4), CXC chemokine receptor 4 (CXCR4), thyroid transcription factor 1 (TTF1) and epidermal growth factor receptor (EGFR) proteins. Methods: We collected brain metastases specimens and lung primary tumor specimens of a series of patients that have not undergone any treatment. Conventional hematoxylin and eosin staining and immunohistochemical staining of target molecules was performed. We used the ImageJ software to process the average optical density value of immune complexes and GraphPad Prism 8.0.1 to perform image analysis, and the SPSS 22.0 statistics package (t test) to analyze the expression differences of target molecules.Results: Based on five cases of brain metastases and two cases of lung primary tumors, a total of seven samples were investigated. Conventional pathology diagnosis reported four cases of brain metastases of lung adenocarcinoma and one case of brain metastases of mixed small cell lung cancer with adenocarcinoma. Among the 19 molecular immunopathological test samples, only GBP4, related to HCMV infection, and TTF1, related to metastases, were highly expressed in all seven samples. A comparison of the AOD values of the primary lung cancer to the AOD values of brain metastases, yielded statistically significant differences as follows: in Case No.1, GBP4 (p=0.016), EGRF (p<0.001); in Case No. 2, IE (p<0.001), CXCR4 (p=0.005), EGFR (p=0.023), TTF1 (p=0.004). Conclusions: Although TTF1 is known to be a kinesin for brain metastases of lung cancer cells and it is associated with poor survival prognosis, the role of GBP4, which is closely related to HCMV infection and a key protein of brain metastases of lung cancer, remains unknown. The findings provide new knowledge into the role of GBP4 and could provide clues for devising novel strategies for target molecular therapy research in brain metastases of lung cancer in the context of HCMV infection.

scholarly journals Expression of Five Target Proteins Related to Human Cytomegalovirus Infection in Brain Metastases of Lung Cancer

2021 ◽  
Author(s):  
Jie Wu ◽  
Haifeng Zhao ◽  
Ke Yan ◽  
Xiangtong Xie ◽  
Donghua Gu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Human Cytomegalovirus ◽  
Hcmv Infection ◽  
Primary Lung Cancer ◽  
Molecular Therapy ◽  
Early Gene ◽  
Primary Tumors ◽  
Target Molecules

Abstract Background: The links between brain metastases of lung cancer and human cytomegalovirus (HCMV) infection have been controversial for a long time. This study aims to explore the links between brain metastases of lung cancer and HCMV infection from the perspective of expression and detection of HCMV immediate early gene (IE), guanine nucleotide-binding protein 4 (GBP4), CXC chemokine receptor 4 (CXCR4), thyroid transcription factor 1 (TTF1) and epidermal growth factor receptor (EGFR) proteins. Methods: We collected brain metastases specimens and lung primary tumor specimens of a series of patients that have not undergone any treatment. Conventional hematoxylin and eosin staining and immunohistochemical staining of target molecules was performed. We used the ImageJ software to process the average optical density value of immune complexes and GraphPad Prism 8.0.1 to perform image analysis, and the SPSS 22.0 statistics package (t test) to analyze the expression differences of target molecules.Results: Based on five cases of brain metastases and two cases of lung primary tumors, a total of seven samples were investigated. Conventional pathology diagnosis reported four cases of brain metastases of lung adenocarcinoma and one case of brain metastases of mixed small cell lung cancer with adenocarcinoma. Among the 19 molecular immunopathological test samples, only GBP4, related to HCMV infection, and TTF1, related to metastases, were highly expressed in all seven samples. A comparison of the AOD values of the primary lung cancer to the AOD values of brain metastases, yielded statistically significant differences as follows: in Case No.1, GBP4 (p=0.016), EGRF (p<0.001); in Case No. 2, IE (p<0.001), CXCR4 (p=0.005), EGFR (p=0.023), TTF1 (p=0.004). Conclusions: Although TTF1 is known to be a kinesin for brain metastases of lung cancer cells and it is associated with poor survival prognosis, the role of GBP4, which is closely related to HCMV infection and a key protein of brain metastases of lung cancer, remains unknown. The findings provide new knowledge into the role of GBP4 and could provide clues for devising novel strategies for target molecular therapy research in brain metastases of lung cancer in the context of HCMV infection.

scholarly journals Lung Cancer That Extended to the Left Atrium Through the Pulmonary Vein: A Case Report

2021 ◽  
Author(s):  
Xin Xu ◽  
Ping Xu ◽  
Ting Ting Wu ◽  
Guo Dong Shang
Keyword(s):  
Lung Cancer ◽  
Left Atrium ◽  
Pulmonary Vein ◽  
Multimodality Imaging ◽  
Pulmonary Veins ◽  
Primary Lung Cancer ◽  
Cardiac Tumors ◽  
Primary Tumors ◽  
Routine Work ◽  
Cardiac Masses

Abstract Background: Metastatic cardiac tumors have been reported in up to 25% of patients with lung cancer, but detection of cardiac involvement via pulmonary veins is neither uncommon nor easy in the routine work. Case presentation: A 68-year-old woman with primary lung cancer was admitted to the hospital with pain in her left leg for 6 months and hemoptysis for one week. TTE detected that a hyperechoic mass in the left atrium which was come from the left inferior pulmonary vein. The result was confirmed by computed tomography.Conclusions: Multimodality imaging should be advocated in the evaluation of cardiac masses especially for patient who has primary tumors.

scholarly journals [18F]AlF-NOTA-FAPI-04 PET/CT uptake in metastatic lesions on PET/CT imaging might distinguish different pathological types of lung cancer

2021 ◽  
Author(s):  
Yuchun Wei ◽  
Kai Cheng ◽  
Zheng Fu ◽  
Jinsong Zheng ◽  
Zhengshuai Mu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Microenvironment ◽  
Lymph Nodes ◽  
Bone Metastases ◽  
Primary Lung Cancer ◽  
Ct Scanning ◽  
Ct Imaging ◽  
Primary Tumors ◽  
Metastatic Lesions ◽  
Pet Ct

Abstract Purpose Heterogeneity is found in the tumor microenvironment among different pathological types of tumors. Radionuclide-labeled fibroblast-activation-protein inhibitor (FAPI), as an important tracer for non-invasive imaging of the tumor microenvironment, can be used to evaluate the expression of FAP in cancer-associated fibroblasts, macrophages, and tumor cells. Our aim was to explore the ability of [18F]AlF-NOTA-FAPI-04 positron emission tomography (PET)/computed tomography (CT) to distinguish different types of lung cancer by evaluating the uptake of this tracer in primary and metastatic lesions. Methods We prospectively enrolled 61 patients with histopathologically proven primary lung cancer with metastases. PET/CT scanning was performed before any antitumor therapy and 1 h after injection of 235.10 ± 3.89 MBq of [18F]AlF-NOTA-FAPI-04. Maximum standard uptake values (SUVmax) were calculated for comparison among primary and metastatic lesions. Immunohistochemical staining for FAP was performed on tumor specimens. Results Sixty-one patients with adenocarcinoma (ADC, n = 30), squamous cell carcinoma (SCC, n = 17), and small cell lung cancer (SCLC, n = 14) were enrolled in this study, and 61 primary tumors and 199 metastases were evaluated. No difference in [18F]AlF-NOTA-FAPI-04 uptake was observed among primary ADC, SCC, and SCLC tumors (P = 0.198). Additionally, no difference in uptake was found between primary and metastatic lesions of lung cancer with the same pathological type (P > 0.05). However, uptake did differ among metastases of differing pathological types (P < 0.001). The SUVmax of metastatic lymph nodes was highest for SCC, followed by ADC and then SCLC (P < 0.001). The SUVmax of bone metastases also was highest for SCC, followed by ADC and SCLC (P < 0.05), but no difference was observed between ADC and SCLC. The SUVmax of metastases in other organs was higher in SCC cases than in ADC cases but did not differ between SCC and SCLC or ADC and SCLC. Bone metastases exhibited higher uptake than those of lymph nodes and other organs in SCC and ADC (P < 0.05) but not in SCLC. Positive correlations were found between FAPI uptake and FAP expression in surgical plus biopsy specimens (r = 0.439, P = 0.012) and surgical specimens (r = 0.938, P = 0.005). Conclusion [18F]AlF-NOTA-FAPI-04 PET/CT imaging revealed differences in FAP expression in metastases of lung cancer, with the highest expression specifically in bone metastases, and thus, may be valuable for distinguishing different pathological types of lung cancer.

Radiographic Findings of Primary Lung Cancer with Delayed Detection on Chest Radiographs

1999 ◽  
Vol 40 (5) ◽  
pp. 879
Author(s):  
Young Min Kim ◽  
Jin Hwan Kim ◽  
Chang Kyu Yang ◽  
Bin Young Jung ◽  
Kwang Jin Jun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Chest Radiographs ◽  
Radiographic Findings

SIALIC ACID IN THE PRIMARY AND DIFFERENTIAL DIAGNOSIS OF LUNG CANCER

2017 ◽  
Vol 63 (6) ◽  
pp. 926-932
Author(s):  
Lyudmila Belskaya ◽  
Viktor Kosenok ◽  
Ж. Массард
Keyword(s):  
Lung Cancer ◽  
Enzyme Activity ◽  
Optimization Problems ◽  
Primary Lung Cancer ◽  
Nonparametric Test ◽  
Nonsmall Cell Lung Cancer ◽  
Group Differences ◽  
Diagnosis Of Lung Cancer ◽  
And Control ◽  
Control Study

So far optimization problems for diagnostics and prognostication aids remained relevant for lung cancer as a leader in the structure of cancers. Objective: a search for regularities of changes in the saliva enzyme activity in patients with nonsmall cell lung cancer. In the case-control study, 505 people took part, divided into 2 groups: primary (lung cancer, n=290) and control (conventionally healthy, n=215). All the participants went through a questionnaire survey, saliva biochemical counts, and a histological verification of their diagnosis. The enzyme activity was measured with spectrophotometry. Between-group differences were measured with the nonparametric test. It was shown that in terms of lung cancer, we observe metabolic changes, described with the decreased de Ritis coefficient (p

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