SIALIC ACID IN THE PRIMARY AND DIFFERENTIAL DIAGNOSIS OF LUNG CANCER

So far optimization problems for diagnostics and prognostication aids remained relevant for lung cancer as a leader in the structure of cancers. Objective: a search for regularities of changes in the saliva enzyme activity in patients with nonsmall cell lung cancer. In the case-control study, 505 people took part, divided into 2 groups: primary (lung cancer, n=290) and control (conventionally healthy, n=215). All the participants went through a questionnaire survey, saliva biochemical counts, and a histological verification of their diagnosis. The enzyme activity was measured with spectrophotometry. Between-group differences were measured with the nonparametric test. It was shown that in terms of lung cancer, we observe metabolic changes, described with the decreased de Ritis coefficient (p

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The Descriptive Epidemiology of Primary Lung Cancer in an Alberta Cohort with a Mutivariate Analysis of Survival to Two Years

Canadian Respiratory Journal ◽

10.1155/2003/729635 ◽

2003 ◽

Vol 10 (8) ◽

pp. 435-441 ◽

Cited By ~ 3

Author(s):

Sandor J Demeter ◽

Chester Chmielowiec ◽

Wayne Logus ◽

Pauline Benkovska-Angelova ◽

Philip Jacobs ◽

...

Keyword(s):

Lung Cancer ◽

Squamous Cell Carcinoma ◽

American Literature ◽

Cell Carcinoma ◽

Squamous Cell ◽

Primary Lung Cancer ◽

Case Fatality ◽

Nonsmall Cell Lung Cancer ◽

Small Cell ◽

The Impact

BACKGROUND: Lung cancer contributes significantly to cancer morbidity and mortality. Although case fatality rates have not changed significantly over the past few decades, there have been advances in the diagnosis, staging and management of lung cancer.OBJECTIVE: To describe the epidemiology of primary lung cancer in an Alberta cohort with an analysis of factors contributing to survival to two years.PATIENTS AND METHODS: Six hundred eleven Albertans diagnosed with primary lung cancer in 1998 were identified through the Alberta Cancer Registry. Through a chart review, demographic and clinical data were collected for a period of up to two years from the date of diagnosis.RESULTS: The mean age at diagnosis was 66.5 years. The majority of cases (92%) were smokers. Adenocarcinoma, followed by squamous cell carcinoma, were the most frequent nonsmall cell lung cancer histologies. Adenocarcinoma was more frequent in women, and squamous cell carcinoma was more frequent in men. The overall two- year survival rates for nonsmall cell, small cell and other lung cancers were 24%, 10% and 13%, respectively. In multivariate analysis, stage, thoracic surgery and chemotherapy were significantly associated with survival to two years in nonsmall cell carcinoma; only stage and chemotherapy were significant in small cell carcinoma.CONCLUSIONS: This study provides a Canadian epidemiological perspective, which generally concurs with the North American literature. Continued monitoring of the epidemiology of lung cancer is essential to evaluate the impact of advances in the diagnosis, staging and management of lung cancer. Further clinical and economic analysis, based on data collected on this cohort, is planned.

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Case-Control Study on Histologically Determined Multiple Primary Lung Cancer2

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/79.3.435 ◽

1987 ◽

Keyword(s):

Lung Cancer ◽

Case Control Study ◽

Primary Lung Cancer ◽

Case Control ◽

Multiple Primary ◽

Control Study

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Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China

BMC Cancer ◽

10.1186/s12885-018-4361-2 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 6

Author(s):

Fei He ◽

Ren-dong Xiao ◽

Tao Lin ◽

Wei-min Xiong ◽

Qiu-ping Xu ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Chinese Population ◽

Case Control Study ◽

Lung Cancer Risk ◽

Primary Lung Cancer ◽

Case Control ◽

Southeast China ◽

Han Chinese Population ◽

Control Study

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Risk factors for primary lung cancer among never smokers by gender in a matched case–control study

Cancer Causes & Control ◽

10.1007/s10552-012-9994-x ◽

2012 ◽

Vol 24 (3) ◽

pp. 567-576 ◽

Cited By ~ 27

Author(s):

Yen-Li Lo ◽

Chin-Fu Hsiao ◽

Gee-Chen Chang ◽

Ying-Huang Tsai ◽

Ming-Shyan Huang ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Case Control Study ◽

Primary Lung Cancer ◽

Case Control ◽

Matched Case ◽

Never Smokers ◽

Matched Case Control Study ◽

Control Study

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Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population

Disease Markers ◽

10.1155/2019/4150263 ◽

2019 ◽

Vol 2019 ◽

pp. 1-23

Author(s):

Qi Shen ◽

Wen-xiang Wang ◽

Qiu-ping Xu ◽

Wen-min Xiong ◽

Zhi-qiang Liu ◽

...

Keyword(s):

Lung Cancer ◽

Case Control Study ◽

Cancer Susceptibility ◽

Primary Lung Cancer ◽

Case Control ◽

Single Nucleotide ◽

History Of ◽

Control Study ◽

History Of Cancer ◽

Lung Cancer Susceptibility

The purpose of the current study is to explore the contribution of single-nucleotide polymorphisms (SNPs) of REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 to the risk of lung cancer. A questionnaire survey was used to obtain basic information of the included subjects. A case control study was performed in 1121 patients and 1121 controls. All subjects were subjected to blood sampling for genomic DNA extraction and genotyping of the cancer stem cell-associated gene SNPs, including REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 by real-time PCR. The association with the risk of primary lung cancer and interaction with environmental factors were assessed using unconditional logistic regression for the odds ratios and corresponding 95% confidence intervals. The genotype frequency distribution of OCT4 rs13409 loci was statistically significant, but there was no significant difference in the rest of the loci between lung cancer patients and healthy controls. The OCT4 gene was also related with lung cancer susceptibility in the genetic model after adjusting for lung cancer-related factors. Despite the presence of the dominant or recessive model, the four loci polymorphisms were associated with pollution near the place of residence, house type, worse ventilation situation, smoking, passive smoking, cooking oil fumes (COF), and family history of cancer, which increased the risk of lung cancer. Nonmarried status, 18.5≤BMI, COF, smoking, passive smoking, family history of cancer, and history of lung disease were independent risk factors of lung cancer susceptibility. Additionally, college degree or above, no pollution near the place of residence, protective genotype 1 or 2, and well ventilation can reduce the occurrence of lung cancer. There is an interaction between the four loci and environmental factors, and OCT4 rs13409 is a risk factor of primary lung cancer.

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Physical Activity and Lung Cancer: A Case-Control Study in Brazil

Journal of Physical Activity and Health ◽

10.1123/jpah.2014-0571 ◽

2016 ◽

Vol 13 (3) ◽

pp. 257-261 ◽

Cited By ~ 1

Author(s):

Maria Laura Resem Brizio ◽

Pedro C. Hallal ◽

I-Min Lee ◽

Marlos Rodrigues Domingues

Keyword(s):

Physical Activity ◽

Lung Cancer ◽

Case Control Study ◽

Leisure Time Physical Activity ◽

Cancer Control ◽

Case Control ◽

Control Subjects ◽

History Of ◽

And Control ◽

Control Study

Background:The aim of this study was to investigate the association between lifetime physical activity and risk of lung cancer.Methods:A case-control study was conducted in southern Brazil. Case subjects were recruited from oncology services of 4 hospitals. Control subjects were selected from the same hospitals, but from different services (traumatology and emergency). Both case subjects (n = 81) and control subjects (n = 168) were interviewed using a questionnaire about sociodemographic characteristics, anthropometric information and family history of cancer. Control subjects were matched to case subjects according to sex and age (± 5 years). Detailed information on smoking was collected. Physical activity was measured using the Lifetime Physical Activity Questionnaire.Results:Of the case subjects, 89% were either current or former smokers; among control subjects, this value was 57%. Participants in the second, third, and fourth quartiles of all-domains physical activity had odds ratios of 0.54 (95% CI, 0.21–1.40), 0.25 (95% CI, 0.08–0.72), and 0.24 (95% CI, 0.07–0.83) for lung cancer, compared with the lowest quartile, after adjusting for confounding. In the fully adjusted models, leisure-time physical activity was not associated with lung cancer risk.Conclusion:Lifetime all-domains physical activity may reduce the risk of lung cancer.

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THE PROCESSES OF LIPOPEROXIDATION AND ENDOGENOUS INTOXICATION IN SALIVA IN CENTRAL AND PERIPHERAL LUNG CANCER

Russian Clinical Laboratory Diagnostics ◽

10.18821/0869-2084-2019-64-5-265-270 ◽

2019 ◽

Vol 64 (5) ◽

pp. 265-270

Author(s):

L. V. Bel’Skaya ◽

V. K. Kosenok ◽

T. V. Postnova

Keyword(s):

Lung Cancer ◽

Control Group ◽

Albumin Concentration ◽

Peripheral Lung Cancer ◽

Hypoxic Conditions ◽

Endogenous Intoxication ◽

Peripheral Lung ◽

And Control ◽

Histological Verification ◽

Control Study

The aim of the study was to establish the patterns of changes in the parameters of endogenous intoxication and lipoperoxidation processes in the saliva of patients with lung cancer, depending on the form of tumor growth (central, peripheral or mediastinal cancer). Materials and methods: in the case - control study was attended by 562 volunteers, who were divided into 2 groups: main (lung cancer, n = 347) and control group (relatively healthy, n = 2015). Questioning, biochemical saliva study and histological verification of the diagnosis carried out to all participants. In peripheral lung cancer, there is a statistically significant increase in the albumin concentration (p˂0.0001), with a central MDA (p=0.0330). The content of secondary lipoperoxidation products compared with the control is increased for all groups (p˂0.0001), however, the differences are most pronounced for the mediastinal growth form. The level of medium molecular toxins is the same for both central and peripheral lung cancer, and the distribution coefficient has a stable value exceeding the corresponding value for the control group (p=0.0002). Thus, in the peripheral form of lung cancer growth under hypoxic conditions lipoperoxidation processes are less pronounced, while endotoxicosis processes are the same in both central and peripheral cancer. For the mediastinal growth, the process of lipoperoxidation is directed towards the formation of toxic Schiff bases, and the low level of medium-molecular toxins indicates a greater resistance of proteins to oxidative stress.

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Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17020591 ◽

2020 ◽

Vol 17 (2) ◽

pp. 591 ◽

Cited By ~ 2

Author(s):

Anna Suraya ◽

Dennis Nowak ◽

Astrid Widajati Sulistomo ◽

Aziza Ghanie Icksan ◽

Elisna Syahruddin ◽

...

Keyword(s):

Lung Cancer ◽

Case Control Study ◽

Risk Model ◽

Asbestos Exposure ◽

Primary Lung Cancer ◽

Case Control ◽

Mean Value ◽

Primary Data ◽

Primary Data Analysis ◽

Control Study

Indonesia has limited data on asbestos-related diseases despite abundant use. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital, Jakarta. The cases had primary lung cancer confirmed by histology, the controls were negative for lung cancer. The cumulative occupational asbestos exposure was calculated by multiplying the exposure intensity by the years of exposure. The exposure intensity was obtained by adopting the weighted arithmetic mean value of asbestos exposure from a job-exposure matrix developed in Korea. The primary data analysis was based on logistic regression. The study included 696 subjects, with 336 cases and 360 controls. The chance of lung cancer for subjects exposed to asbestos was doubled (OR = 2.04, 95% CI = 1.21–3.42) compared with unexposed, and subjects with a cumulative asbestos exposure of 10 fiber-years or more even showed an OR of 3.08 (95% CI = 1.01–9.46). The OR of the combined effect between smoking and asbestos was 8.7 (95% CI = 1.71–44.39); the interaction was consistent with an additive and multiplicative risk model. Asbestos exposure is associated with a higher chance of lung cancer. Improved policies are needed to protect the population from asbestos hazards.

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