Effect of Combination Therapy with Extended-Release Metformine and Glimepiride on Carbohydrate and Lipid Metabolism in Patients with Type 2 Diabetes Mellitus

A sex difference of carbohydrate and lipid metabolism disorders in rats with type 2 diabetes has been studied. It was established that type 2 diabetes leads to a more pronounced deterioration in carbohydrate toleranceand insulin sensitivity in males compared to female rats, but the sex doesn’t affect basal glycemia and fructosamine levels. It was found that the increase of body weight and visceral fat in rats with type 2 diabetes is moremanifested in females than in males. It has been determined that hypertriglyceridemia is higher in diabeticmales compared to diabetic females, and the level of common lipids in the liver, both intact females and femaleswith type 2 diabetes, is lower than that of the males. The obtained results indicate a more expressive impairment of glucose and lipid metabolism in males compared to females with type 2 diabetes

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Impact of hypolipidemic therapy on carbohydrate and lipid metabolism and their hormonal regulators in patients with type diabetes mellitus

Problems of Endocrinology ◽

10.14341/probl11418 ◽

2003 ◽

Vol 49 (1) ◽

pp. 25-27

Author(s):

N. T. Starkova ◽

V. V. Dolgov ◽

A. L. Davydov ◽

A. P. Roitman ◽

L. Yu. Baranova ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lipid Metabolism ◽

Normal Values ◽

Control Group ◽

Obese Patients ◽

Carbohydrate And Lipid Metabolism ◽

Daily Dose

The effects of lipostat and maninil on carbohydrate and lipid metabolisms and their hormonal regulators were studied in 36 obese patients aged 50- 70 years who had type 2 diabetes mellitus concurrent with dyslipidemia. A course of therapy with lipostat in a daily dose of 20 mg for 3 months was shown to lead to normalization of lipid metabolism, to diminished glycemia and hy- perinsulinemia, and to an increase in fasting plasma somatotropic hormone levels to normal values, these were not observed in the control group.

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Status of carbohydrate and lipid metabolism in obese patients with type 2 diabetes mellitus after biliopancreatic diversion surgery

Obesity and metabolism ◽

10.14341/2071-8713-3862 ◽

2013 ◽

pp. 28-36 ◽

Cited By ~ 5

Author(s):

E V Ershova ◽

◽

Yuriy Ivanovich Yashkov

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lipid Metabolism ◽

Biliopancreatic Diversion ◽

Obese Patients ◽

Carbohydrate And Lipid Metabolism ◽

Biliopancreatic Diversion Surgery

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The effect of a single bout of exhaustive exercise on muscle carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus

Acta Diabetologica ◽

10.1007/s005920070035 ◽

2000 ◽

Vol 37 (1) ◽

pp. 47-53 ◽

Cited By ~ 15

Author(s):

M. Strączkowski ◽

I. Kowalska ◽

J. Górski ◽

I. Kinalska

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lipid Metabolism ◽

Rat Model ◽

Exhaustive Exercise ◽

Carbohydrate And Lipid Metabolism ◽

Single Bout

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Effect of testosterone on lipid metabolism and endothelium in men with type 2 diabetes mellitus and hypogonadism

European Heart Journal ◽

10.1093/ehjci/ehaa946.3827 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

I Khripun ◽

S Vorobyev ◽

A Khripun ◽

M Kogan ◽

A Demidova ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lipid Metabolism ◽

Control Group ◽

Funding Source ◽

Carbohydrate And Lipid Metabolism ◽

Time Point

Abstract Background To date, knowledge about the effects of testosterone (T) on the cardiovascular system of men remains controversial and requires additional research. Especially the putative impact of T replacement therapy (TRT) on lipid metabolism and endothelial dysfunction as a starting mechanism for the development of cardiovascular pathology in men with type 2 diabetes mellitus (T2DM) presenting with T deficiency has to be elucidated. The aim of this work was to evaluate the effect of T replacement therapy on lipid metabolism and function of endothelium in men with T2DM and hypogonadism. Methods The study included 95 men (mean age 55,3±2,4 years) with T2DM and late onset hypogonadism, established according to EAU 2015 criteria. Parameters of carbohydrate and lipid metabolism, as well as ultrasound assessment of flow-mediated dilatation of the brachial artery (FMD-BA) and intima-media thickness (IMT) of brachial arteries were performed at baseline and after 9 months. Patients were randomized into 2 groups: 1 - 45 men receiving TRT, using 1% transdermal T-gel and 2 (control group) - 50 men, who were not assigned to TRT. Statistical analysis was carried out using the Wilcoxon - test for repeated measurements (STATISTICA 10 software package). Results During the treatment period no serious adverse events were registered. The study revealed a significant decrease in HbA1c (p<0.001), total cholesterol (p=0.009), triglycerides (p=0.004) and LDL (p=0.01) levels as well as an increase in HDL level (p=0.001) in the 1st group vs baseline and compared to the 2nd one. There was a decrease in IMT (from 1.0 [0.8; 1.1] to 0.7 [0.6; 0.9] mm, p=0.002) in the 1st group compared to the 2nd (p<0.001). The endothelium-dependent FMD-BA increased 1.5 - fold in men applying T-Gel vs baseline as well as compared to the control group at the time point of follow- up (p<0.001). At the same time TRT leaded to acceleration of the time until maximal vasodilation – it became twice faster (from 120 [90; 120] to 60 [60; 90] sec, p<0.001) compared to baseline and the 2nd group (p<0.001). Linear blood flow velocity increased markedly in the 1st group compared to the 2nd at the time point of follow-up (p=0.03). Conclusion TRT in men with T2DM and T deficiency leads to an improvement in carbohydrate and lipid metabolism together with a significant decrease in IMT and enhancement of endothelium vasomotor function, seems to facilitate a reduction in cardiovascular risk. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Russian Science Foundation

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The epifamin effect on values of immune status, carbohydrate and lipid metabolism in the patients with non-alcoholic steatohepatitis developing at type 2 diabetes mellitus

Journal of New Medical Technologies eJournal ◽

10.12737/5038 ◽

2014 ◽

Vol 8 (1) ◽

pp. 1-7

Author(s):

Золоедов ◽

V. Zoloedov ◽

Агарков ◽

A. Agarkov ◽

Попов ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lipid Metabolism ◽

Immune Status ◽

Atherogenic Index ◽

Alcoholic Steatohepatitis ◽

Carbohydrate And Lipid Metabolism ◽

Basic Treatment

The study is devoted to the Epifamin effect on values of carbohydrate and lipid metabolism, immune status in blood, and also content of 6-sulfatohymelatonin as the main metabolite of melatonin, in urine of the patients with non-alcoholic steatohepatitis developing at type 2 diabetes mellitus. It is shown that fasting glucose, postprandial glucose level and glycated hemoglobin content in the blood of patients decreased significantly during combined treatment with the Epifamin compared to the basic therapy. The results of the Epifamin reception are as follows: more expressed normalization of lipid metabolism, and content of β -lipoproteins, cholesterol, lipoproteins of low density and high density lipoprotein, and atherogenic index in comparison with the results obtained after basic treatment. The obtained results testify to positive Epifamin effect on values of the immune status of patients: level of circulating immune complexes, the main classes of immunoglobulins – IgA, IgM, IgG. It was established that in the patients with non-alcoholic steatohepatitis developing at type 2 diabetes mellitus, 6-sulfatohymelatonin level in urine was lowered on the average by 1,2 times in comparison with control. After basic treatment the reliable changes of the 6-sulfatohymelatonin content in the patients didn’t reveal. After the combined therapy with the Epifamin, the 6-sulfatohymelatonin content in the patients increased on the average for 13.9%. The obtained results allow to conclude about correction the Epifamin effect on melatonin content as a hormone, which able to participate in regulation of carbohydrate and lipid metabolism and to have immune modulating action. The Epifamin use in basic treatment had favorable influence on the immune status, values of carbohydrate and lipid metabolism in blood in the patients with non-alcoholic steatohepatitis developing at type 2 diabetes mellitus that was apparently due to melatonin-corrective effect of this drug.

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