Optimal integration of CDK4/6 inhibitors for treatment of hormone receptor-positive metastatic breast cancer
Keyword(s):
The paper analyzes the effectiveness of a new class of medications — CDK4/6 cyclin-dependent kinases inhibitors and discover the mechanism of its action. The article describes the general results of studies on palbociclib, ribociclib and abemaciclib* for the first- and subsequent-line of the therapy of HR-positive/HER2-negative metastatic breast cancer. The profile of adverse events of approved CDK4/6 inhibitors are considered. The combination of CDK4/6 inhibitors with endocrine therapy was shown to have benefits in survival, potentiality to reduce hormone resistance and great perspectives to improve clinical results of hormone receptor-positive metastatic breast cancer.
2019 ◽
Vol 19
(1)
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pp. e186-e194
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2009 ◽
Vol 27
(33)
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pp. 5529-5537
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2020 ◽
Vol 3
(10)
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pp. e2020312
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2021 ◽
Vol 13
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pp. 175883592098765
2021 ◽
Vol 13
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pp. 175883592110069