scholarly journals PHYSICAL, CHEMICAL CHARACTERISTICS AND RELEASE RATE OF MELOXICAM FROM NANOSTRUCTURED LIPID CARRIERS (NLC) SYSTEM USING SOME CONCENTRATION RATIOS OF MONOSTEARIN AND ALPHA TOCOPHEROL ACETATE LIPID MATRIX

Author(s):  
Yulia Anggraeni ◽  
Isnaeni Isnaeni ◽  
Esti Hendradi

Objective: The objective of this research is to develop nanostructured lipid carriers (NLC) of meloxicam (MLX) for topical application using monostearin and alpha-tocopherol as lipid matrix.Methods: MLX-NLC was prepared by high-shear homogenization, and it was characterized for organoleptic, pH, viscosity, particle size and size distribution, zeta potential, crystallinity, morphology, and entrapment efficiency. The six different ratios of solid and liquid lipid matrix were70:30, 75:25, 80:20, 85:15, 90:10, and 95:5, respectively.Results: The pH value of all formulas met the pH range of topical dosage at 4.5-6.5. Viscosity test showed that a trend toward the decrease in viscosity with the increase in alpha-tocopherol content was observed. The results of particle size test proved that all six NLC system formulas have <1000 nm particle size with a quite narrow particle size distribution. Scanning electron microscope revealed nearly spherical shape NLC with negligible effect ratios of solid and liquid lipid on the particle morphology. The X-ray diffraction result showed the decreasing of peaks intensity of MLX-NLC system. It showed that MLX in NLC system is amorphous. The result showed that the increasing concentration of liquid lipid in NLC system caused the rising entrapment efficiency of MLX.Conclusion: The result of this research indicates that the concentration ratio of monostearin and alpha-tocopherol acetate affects the physical and chemical characteristics of NLC system.Keywords: Nanostructured lipid carriers, Meloxicam, Monostearin, Physical and chemical characteristics, Entrapment efficiency. 

2021 ◽  
Author(s):  
Ivan Kushnov ◽  
Evgeny Abakumov ◽  
Rustam Tembotov ◽  
Viacheslav Polyakov

&lt;p&gt;Cryoconites are a dark-colored granular sediments found in glacial landscapes. Cryoconites are known as a dark colored accumulation of various origin material in superficial holed of the glaciers which formed in polar and mountain regions of the Earth. They can significantly accelerate glacier retreating by reducing the albedo of the glacier and play a significant role in the colonization of the territory after its retreat, being an &quot;oasis&quot; for development of microorganisms on an uninhabited glacier surface. The understanding of key cryoconites properties is necessary to understand their impact on the mountain glaciers of the Central Caucasus, especially taking into account their recent rapid retreat.&lt;/p&gt;&lt;p&gt;The aim of this research is to study the physical and chemical characteristics of various cryoconites and cryoconite derived periglacial soils of the Central Caucasus. Eight cryoconite samples and eight soil samples from three soil sections were selected. The following characteristics of the samples were determined in laboratory conditions: total organic carbon (TOC), basal respiration level, pH H&lt;sub&gt;2&lt;/sub&gt;O and exchangeable soil acidity, solid phase density and particle size distribution.&lt;/p&gt;&lt;p&gt;The results of the analyses showed both differences and some similarities in the physical and chemical characteristics of the cryoconites and soils of periglacial zone which were studied. Cryoconites, on average, are characterized by lower values of basal respiration than more developed soils from this region. The total organic carbon content in most samples was relatively low, but its values increase significantly soils investigated due to accumulation of carbon in fine earth under the influence of primary vegetation. The water extractable acidity values showed a significant similarity between the studied cryoconites and soils, they vary from slightly acidic to slightly alkaline in both groups. At the same time, the variation of exchangeable acidity values between cryoconite samples is significantly greater than in developed soils. Moreover, the density of the solid phase of the studied cryoconites varies in a larger range of values than that of the studied soils due to variety of sources of cryoconite materials. However, the analysis of particle size distribution showed a significant similarity of the studied objects: in almost all samples there is a significant dominance of the sand fraction (d=1-0.05 mm). The obtained data indicate both the difference in the physical and chemical properties of the studied cryoconites among themselves, and the probable influence of cryoconites on soil formation in this region.&lt;/p&gt;&lt;p&gt;This work was supported by Russian Foundation for Basic Research, project No &lt;strong&gt;19-05-50107&lt;/strong&gt; &amp;#160;&amp;#8220;The role of microparticles of organic carbon in degradation of ice cover of polar regions of the Earths and in the process of soil-like bodies formation&amp;#8221;.&lt;/p&gt;


2021 ◽  
Vol 19 (01) ◽  
pp. 97-105
Author(s):  
RUS DINA RUS DIN ◽  
SERI MIRIANTI ISHAR ◽  
HEMANANTHINI NAGANATHAN

Soil sample is one of the important evidence that can be found in crime scene. Unknown soil sample can be analysed and compared with reference sample in order to determine the origin as its physical and chemical components possess unique characteristics. The purpose of this study is to determine the physical and chemical characteristics of soil from oil palm plantations in Perak, Malaysia to assist forensic investigation. Total of 97 topsoil samples were collected from three different oil palm plantations in Perak. Particle size distribution was obtained using dry sieving technique and colour of soil sample was examined under three conditions that are dry, moist and ashed. Soil pH was measured using pH meter and percentage of composition of soil organic matter (SOM) was determined by weighing the sample before and after ignition. Result showed that the composition of particle size <0.18mm was within the range of 5.57-21.11% whereas for particle size between 0.18mm - 0.6mm was within 31.62 - 52.96% and 25.78-66.86% for particle size >0.6mm. The color mode of soil after oven dried, moistened and ashed was greyish brown (10YR 5/2), very dark greyish brown (10YR 3/2) and light yellowish brown (10YR 6/4) respectively. Soil pH was in the range of 5.79 – 6.70. The percentage of SOM was between 3.29 - 20.48%. The physical and chemical characteristics of soil analysed in this study from three different locations of oil palm plantations varied and it is possible to discriminate these locations based on the analysis highlighted in this study.


2010 ◽  
Vol 113-116 ◽  
pp. 639-643
Author(s):  
Laid Baali ◽  
A. Naceri ◽  
Z. Rahmouni ◽  
S. Sekhara

Siliceous sand (dune sand) was partially replaced by slag sand (SS) at different proportions (0, 5, 10, 15, 20 and 25%). Using two types of fine aggregates, dune sand (DS) and slag sand (SS), grading, compressive and flexural strengths are measured on mortar. Physical and chemical characteristics of dune sand (DS), slag sand (SS) and cement were determined in this study. The results obtained indicate that the mechanical strength of mortar made with binary sand (DS/SS) depends of the nature and particle size distribution of sand studied.


Food Industry ◽  
2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Nataliia V. Nepovinnykh ◽  
Yuri A. Kodatsky ◽  
Oksana N. Klyukina ◽  
Nataliia M. Ptichkin ◽  
Samira Yeganehzad

2013 ◽  
Vol 39 (6) ◽  
pp. 1089
Author(s):  
Qian ZHANG ◽  
Ming-Cai ZHANG ◽  
Hai-Yan ZHANG ◽  
Wei-Ming TAN ◽  
Zhao-Hu LI ◽  
...  

The objective of this present study was to investigate the effect of feeding fermented mixture of papaya leaf and seed meal (FERM) on the physical and chemical characteristics of meats of the Indonesian indigenous crossbred chicken (IICC). The study was carried out with 300 day-old IICC. The chicks were randomly distributed to five treatment groups, i.e., CONT (control diet based on corn-soybean- diet), FERMA (diet containing 1% FERM), FERMB (2.5% FERM), FERMC (5% FERM) and FERMD (7.5% FERM). Each treatment group consisted of 6 replicates with 10 IICC in each. At week 8, one chick from each replicate was randomly taken and slaughtered. After being de-feathered and eviscerated, samples from breast and thigh meats were obtained. Results showed that the increased levels of FERM was followed by the increased (P<0.05) pH values, moisture and crude protein content of breast meats of the IICC. Dietary incorporation of FERM especially at the level of 2.5% increased (P<0.05) the content of fat in the breast meat of IICC, while further increased levels of FERM did not alter (P>0.05) the fat content of the IICC breast meat. Dietary treatment did not have any effect (P>0.05) on the lightness (L*) values of breast meat of the IICC. The redness (a*) values were higher (P<0.05) in FERMD breast meat than other. FERM diet resulted in lower (P<0.05) yellowness (b*) values in the IICC breast meat. The pH values and moisture content of thigh meat increased (P<0.05) with the increased level of FERM. The WHC decreased (P<0.05) with the elevated levels of FERM in the diets. There was an increase (P<0.05) in crude protein concentration in FERMA as compared to the other meats. Crude fat and ash concentrations in thigh meat were affected (P<0.05) by the treatments. Dietary treatments had no impact (P>0.05) on L* values of thigh meats. Feeding FERM at 7.5% from diets increased (P<0.05) and decreased (P<0.05) the redness and yellowness of meats. In conclusion, dietary inclusion of FERM especially at the level of 7.5% from diets improved the physical and chemical characteristics of the IICC meats.


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