scholarly journals SELECTED EXCIPIENTS IN ORAL SOLID DOSAGE FORM WITH DRY EXTRACT OF PYROLA ROTUNDIFOLIA L.

2019 ◽  
pp. 210-216 ◽  
Author(s):  
NATALIA DARZULI ◽  
LILIIA BUDNIAK ◽  
TARAS HROSHOVYI
Keyword(s):  
Dosage Form ◽  
Second Order ◽  
Direct Compression ◽  
Optimal Composition ◽  
Compression Method ◽  
Dry Extract ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Croscarmellose Sodium ◽  
Upper Level

Objective: The aim of the present study was to select excipients in an oral solid dosage form with a dry extract of round-leaved wintergreen (Pyrola rotundifolia L.) by using asymmetric, rotatable composite plan of the second-order (uniform plan No. 17). Methods: The tablets were prepared by using a direct compression method. The most important pharmaceutical factors selected were considered in more details at developing the optimal composition and technology of the studied tablets of the round-leaved wintergreen extract. Each one was studied at five levels using asymmetric, rotatable composite plan of the second order. Results: Increasing amounts of PROSOLV® EASYtab SP and croscarmellose sodium in the powder mass, its flowability decreases, and increasing amounts of Tablettose® 80 improves flowability. Increasing the amount of Tablettose® 80 in the tablets composition leads to improved uniformity. The strength of the tablets increased with increasing amounts of Neusilin® US 2 at different combinations of levels of the other three factors. When studying the effect of the amounts of croscarmellose sodium on the disintegration of tablets, it was found that the best disintegration values were obtained in the study of croscarmellose sodium at the upper level. Conclusion: Oral solid dosage form with dry extract of round-leaved wintergreen was successfully prepared by the direct compression method. The optimal composition of tablets was determined by the regression analysis.

scholarly journals SELECTION OF A FILLER FOR TABLETS MANUFACTURED WITH DIRECT COMPRESSION METHOD CONTAINING DRY GINGER EXTRACT

2019 ◽  
Vol 3 ◽  
pp. 26-34 ◽  
Author(s):  
Оlena Ruban ◽  
Malek Alkhalaf ◽  
Nataliia Gerbina
Keyword(s):  
Dosage Form ◽  
Moisture Absorption ◽  
Angle Of Repose ◽  
Direct Compression ◽  
Technological Properties ◽  
Ginger Extract ◽  
Dry Extract ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Physico Chemical

The preliminary studies of physico-chemical and pharmaco-technological properties of the dry extract of ginger have determined the need for introduction of different groups of excipients for developing a solid dosage form for the treatment of type II diabetes mellitus. Aim. To choose the rational filler in the composition of tablets with ginger obtained by direct compression. Materials and methods. The study object was the dry extract of ginger (DEG) (producer “Megaprom”, Dnepr,Ukraine) and modern excipients for the production of tablets by direct compression: GalenIQ 721 (BENEO-Palatinit Gmb), Flowlac 100 (Meggle Co.), Tablettose 80 (Meggle Co.), Farmaxx (Merck), Microcelac 100 (Meggle Co.), Vivapur 112 and 102 (JRS Pharm), Prosolv HD 90, Prosolv SMCC 50 (JRS Pharm) manufactured in Germany. Pharmaco-technological and physico-chemical properties of the samples were studied according to conventional methods of the State Pharmacopoeia of Ukraine. Results and discussion. According to the results of the crystallographic analysis, the ability to the moisture absorption, resistance to crushing, disintegration time, fluidity indicators, angle of repose and bulk volume the effect of modern excipients on physicochemical and pharmaco-technological properties of the dry extract of ginger has been studied. Conclusions. According to the results of microscopic analysis, it has been found, that the rational fillers are GalenIQ 721, Prosolv HD 90, Prosolv SMCC 50, Vivapur 102 and Vivapur 112, as they provide a uniform system and the necessary resistance to destruction. The study of the kinetics of the moisture absorption has shown that addition of the fillers significantly reduces the increase in moisture compared to the dry extract. The mixture with GalenIQ 721 has the lowest parameters of moisture absorption at a relative air humidity of 45 %, 75 % and 100 %. In accordance with the results of the pharmaco-technological studies, it has been found that addition of GalenIQ 721 leads to improved flowability, disintegration, settling qualities; it indicates the feasibility of its inclusion into the composition of the solid dosage form.

scholarly journals DEVELOPMENT OF TABLET TECHNOLOGY QUALITY CONTROL BASED ON GERANIUM COLLINA (GERANIUM COLLINUM STEPH.)

2019 ◽  
pp. 92-96
Author(s):  
Zamira Tanirbergenovna Pazilbekova ◽  
Feruza Alisherovna Umarova
Keyword(s):  
Quality Control ◽  
Quality Assessment ◽  
Dosage Form ◽  
Raw Materials ◽  
Dosage Forms ◽  
Technological Parameters ◽  
Optimal Method ◽  
Dry Extract ◽  
Solid Dosage Form ◽  
Solid Dosage

The article presents scientific studies of dosage forms obtained on the basis of a plant growing on the Uzbekistan Geranim collina - (Geranium collinum Steph.) Studied obtaining a dry extract from a plant Geranium collina with different extractants, methods for its preparation, the optimal method for obtaining a dry extract is substantiated. The article also describes the phators that influence the production of dry extracts such as the choice of extractant, hydromodule, degree of grinding of raw materials, quality assessment and standardization. Based on the obtained dry extract of Geranium collina, a solid dosage form - tablets, was obtained. Their technological parameters were studied, as well as quality assessment and expiration dates. KEYWORDS: extractant, Geranim collina, dry exstrakt, tablets, percolation, tannins, hydromodule.

scholarly journals Evaluation of Tropaeolin 000-1 as a Colorimetric Reagent for Assay of Duloxetine and Escitalopram in Solid Dosage Form

2016 ◽  
Vol 15 (3) ◽  
pp. 613
Author(s):  
Mani Ganesh ◽  
Abidov Sh Aziz ◽  
Mei Mei Peng ◽  
Ramaswamy Ravikumar ◽  
Kalaimani Sakthimanigandan ◽  
...  
Keyword(s):  
Dosage Form ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Colorimetric Reagent

Formulation and Evaluation of Orodispersble Tablet

2021 ◽  
pp. 267-272
Author(s):  
Pratiksha S. Deore ◽  
Yashpal M. More ◽  
Avish D. Maru
Keyword(s):  
Rapid Onset ◽  
Nausea And Vomiting ◽  
Direct Compression ◽  
Compression Method ◽  
Onset Of Action ◽  
Orodispersible Tablet ◽  
Croscarmellose Sodium

The aim of present work is to formulate and develop tablets of promethazine HCL.by using various superdisintegrating agent by direct compression method. The main objective of the study is to increase rapid onset of action of promethazine HCL in the treatment of nausea and vomiting. The orodispersible tablet of promethazine hcl is were prepared by direct compression method. Using different concentration of Crospovidone, croscarmellose sodium Mannitol, lactose, maltose, mg. stearate. The tablet was evaluated by various parameters and result are found to be satisfactory.

scholarly journals Comparison of UV-spectrophotometric and RP-HPLC methods for estimation of deflazacort in solid dosage form

2020 ◽  
Author(s):  
Puranik Manisha ◽  
Shambharkar Samta ◽  
Nimbalkar Shantanu ◽  
Mahapatra Debarshi Kar
Keyword(s):  
Dosage Form ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Rp Hplc
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