scholarly journals SELECTION OF A FILLER FOR TABLETS MANUFACTURED WITH DIRECT COMPRESSION METHOD CONTAINING DRY GINGER EXTRACT

2019 ◽  
Vol 3 ◽  
pp. 26-34 ◽  
Author(s):  
Оlena Ruban ◽  
Malek Alkhalaf ◽  
Nataliia Gerbina
Keyword(s):  
Dosage Form ◽  
Moisture Absorption ◽  
Angle Of Repose ◽  
Direct Compression ◽  
Technological Properties ◽  
Ginger Extract ◽  
Dry Extract ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Physico Chemical

The preliminary studies of physico-chemical and pharmaco-technological properties of the dry extract of ginger have determined the need for introduction of different groups of excipients for developing a solid dosage form for the treatment of type II diabetes mellitus. Aim. To choose the rational filler in the composition of tablets with ginger obtained by direct compression. Materials and methods. The study object was the dry extract of ginger (DEG) (producer “Megaprom”, Dnepr,Ukraine) and modern excipients for the production of tablets by direct compression: GalenIQ 721 (BENEO-Palatinit Gmb), Flowlac 100 (Meggle Co.), Tablettose 80 (Meggle Co.), Farmaxx (Merck), Microcelac 100 (Meggle Co.), Vivapur 112 and 102 (JRS Pharm), Prosolv HD 90, Prosolv SMCC 50 (JRS Pharm) manufactured in Germany. Pharmaco-technological and physico-chemical properties of the samples were studied according to conventional methods of the State Pharmacopoeia of Ukraine. Results and discussion. According to the results of the crystallographic analysis, the ability to the moisture absorption, resistance to crushing, disintegration time, fluidity indicators, angle of repose and bulk volume the effect of modern excipients on physicochemical and pharmaco-technological properties of the dry extract of ginger has been studied. Conclusions. According to the results of microscopic analysis, it has been found, that the rational fillers are GalenIQ 721, Prosolv HD 90, Prosolv SMCC 50, Vivapur 102 and Vivapur 112, as they provide a uniform system and the necessary resistance to destruction. The study of the kinetics of the moisture absorption has shown that addition of the fillers significantly reduces the increase in moisture compared to the dry extract. The mixture with GalenIQ 721 has the lowest parameters of moisture absorption at a relative air humidity of 45 %, 75 % and 100 %. In accordance with the results of the pharmaco-technological studies, it has been found that addition of GalenIQ 721 leads to improved flowability, disintegration, settling qualities; it indicates the feasibility of its inclusion into the composition of the solid dosage form.

scholarly journals SELECTED EXCIPIENTS IN ORAL SOLID DOSAGE FORM WITH DRY EXTRACT OF PYROLA ROTUNDIFOLIA L.

2019 ◽  
pp. 210-216 ◽  
Author(s):  
NATALIA DARZULI ◽  
LILIIA BUDNIAK ◽  
TARAS HROSHOVYI
Keyword(s):  
Dosage Form ◽  
Second Order ◽  
Direct Compression ◽  
Optimal Composition ◽  
Compression Method ◽  
Dry Extract ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Croscarmellose Sodium ◽  
Upper Level

Objective: The aim of the present study was to select excipients in an oral solid dosage form with a dry extract of round-leaved wintergreen (Pyrola rotundifolia L.) by using asymmetric, rotatable composite plan of the second-order (uniform plan No. 17). Methods: The tablets were prepared by using a direct compression method. The most important pharmaceutical factors selected were considered in more details at developing the optimal composition and technology of the studied tablets of the round-leaved wintergreen extract. Each one was studied at five levels using asymmetric, rotatable composite plan of the second order. Results: Increasing amounts of PROSOLV® EASYtab SP and croscarmellose sodium in the powder mass, its flowability decreases, and increasing amounts of Tablettose® 80 improves flowability. Increasing the amount of Tablettose® 80 in the tablets composition leads to improved uniformity. The strength of the tablets increased with increasing amounts of Neusilin® US 2 at different combinations of levels of the other three factors. When studying the effect of the amounts of croscarmellose sodium on the disintegration of tablets, it was found that the best disintegration values were obtained in the study of croscarmellose sodium at the upper level. Conclusion: Oral solid dosage form with dry extract of round-leaved wintergreen was successfully prepared by the direct compression method. The optimal composition of tablets was determined by the regression analysis.

scholarly journals The pharmaco-technological studies of the tablet solid dosage form for the treatment of otolarynological diseases

2020 ◽  
pp. 51-60
Author(s):  
М. К. Гулзода ◽  
A. У. Рахмонов ◽  
К. С. Махсудов ◽  
Р. С. Мусоєв ◽  
С. M. Мусозода ◽  
...  
Keyword(s):  
Dosage Form ◽  
Raw Materials ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Technological Properties ◽  
Medicinal Products ◽  
Solid Dosage Form ◽  
Plant Raw Materials ◽  
Solid Dosage ◽  
Active Substances

The prevalence of acute respiratory diseases, the particular severity of their course, as well as the frequent relapses and complications require constant search for new, more effective and safe medicines for their prevention and treatment and introduction of these drugs into clinical practice. Generally, most of the medications used in the treatment of acute respiratory viral infections have a number of side effects. Currently, one of the promising areas of pharmacy is the study of biologically active substances, the medicinal plant raw material, and production of extracts and herbal medicines based on them. Objective – pharmaceutical development of a scientifically based composition, technology for obtaining anti-inflammatory and antimicrobial tablets developed on the basis of a selected and standardized plant substance-a thick extract of the leaves of sage nutmeg, which grows in Tajikistan.  When solving the task used the methods of evaluating the technological properties of LRS, physico-chemical properties of plant extracts, physical and technological properties of the mass for tabletting, pharmaco-technological tests of the developed tabletsa study of quantitative content of biologically active substances was determined by Pharmacopoeia methods. The developed solid dosage form with thick extract of sage leaves can be registered as a medicinal product, and the developed technology of tablets with thick extract of sage leaves can be of interest to manufacturers of medicinal products from plant raw materials. The developed methods can be used in laboratories for the detection and quantitative determination of BAS in plant raw materials of Clary sage leaves and medicinal products from this LRS. Thus, based on the results of pharmacological and technological research, we have developed a technology for obtaining a thick extract of sage nutmeg and tablets based on it for the treatment of otolaryngological diseases, which in turn is of interest for further research of the developed drug and its introduction into production.

scholarly journals Research of physico-chemical and technological properties of thioctic acid

2018 ◽  
pp. 71-78
Author(s):  
I. V. Kovalevska ◽  
O. A. Ruban
Keyword(s):  
Compression Ratio ◽  
Dosage Form ◽  
Solid Dispersions ◽  
Slope Angle ◽  
Chemical Properties ◽  
Thioctic Acid ◽  
Technological Properties ◽  
Solid Dosage ◽  
Physico Chemical ◽  
Solubility Determination

Characteristics and relevance of article topic. Analysis of the literature data shows that the thioctic acid preparations are widely used in the treatment of various diseases. At it’s parenteral application inter- and intraindividual level at the plasma can vary significantly. Therefore, the bioavailability of thioctic acid according to the results of clinical researches is only 30% and efficacy largely dependent on the technological features of the dosage form manufacturing process. The goal of paper was researches of the thioctic acid physico-chemical properties for development of composition and technology of solid dosage form with improved bioavailability. Thioctic acid was the object of the study. The complex of physical, chemical and technological tests were used during researches: microscopic, thermal analyzes studies of bulk density, flowability, compression ratio, hygroscopicity, dissolution. Conclusions. According to thermal analysis, thermal stability of thioctic acid sample has been established within 20–180 °C. The results can be used for explanation the temperature regime in the preparation of solid dispersions of thioctic acid by the melting method. Solubility determination according to SP of Ukraine II-ed. and microscopic method showed that the substance is readily soluble in 96% ethanol, which leads to the conclusion about the possibility of preparation thioctic acid solid dispersions by dissolution method. During researches were established physico-chemical and technological properties of the thioctic acid substance, produced by Shanghai modern pharmaceutical Co., LTD (China). Were established that the substance is hygroscopic as evidenced by the change in appearance and weight. It was determined that the substance does not have a satisfactory yield (Carr index – 1,39, slope angle – 60°), compression ratio is 0,495, which is indicative of the lack of sample strength after the removal of pressure. The results of the studies suggest that the physicochemical properties of the substance needed modifications in the manufacture of solid dosage forms with thioctic acid.

scholarly journals DEVELOPMENT OF TABLET TECHNOLOGY QUALITY CONTROL BASED ON GERANIUM COLLINA (GERANIUM COLLINUM STEPH.)

2019 ◽  
pp. 92-96
Author(s):  
Zamira Tanirbergenovna Pazilbekova ◽  
Feruza Alisherovna Umarova
Keyword(s):  
Quality Control ◽  
Quality Assessment ◽  
Dosage Form ◽  
Raw Materials ◽  
Dosage Forms ◽  
Technological Parameters ◽  
Optimal Method ◽  
Dry Extract ◽  
Solid Dosage Form ◽  
Solid Dosage

The article presents scientific studies of dosage forms obtained on the basis of a plant growing on the Uzbekistan Geranim collina - (Geranium collinum Steph.) Studied obtaining a dry extract from a plant Geranium collina with different extractants, methods for its preparation, the optimal method for obtaining a dry extract is substantiated. The article also describes the phators that influence the production of dry extracts such as the choice of extractant, hydromodule, degree of grinding of raw materials, quality assessment and standardization. Based on the obtained dry extract of Geranium collina, a solid dosage form - tablets, was obtained. Their technological parameters were studied, as well as quality assessment and expiration dates. KEYWORDS: extractant, Geranim collina, dry exstrakt, tablets, percolation, tannins, hydromodule.

scholarly journals DEVELOPMENT OF A SOLID DOSAGE FORM WITH ADSORPTION ACTIVITY

2021 ◽  
Vol 8 (4) ◽  
pp. 233-241
Author(s):  
M. V. Chirkova ◽  
D. K. Gulyaev ◽  
M. P. Chugunova ◽  
V. D. Belonogova
Keyword(s):  
Picea Abies ◽  
Dosage Form ◽  
Raw Materials ◽  
Water Soluble ◽  
Technological Properties ◽  
Adsorption Activity ◽  
Polysaccharide Complex ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Soluble Polysaccharide

Enterosorbents are produced in various dosage forms – powders, tablets, pastes, etc., some of them are also manufactured in the form of capsules. A water-soluble polysaccharide complex (WSPC) manifesting a pronounced adsorption activity, which determines the prospects for the development of dosage forms of sorbents, was obtained from the cones of European Spruce (Picea abies).The aim of the work is to develop a solid dosage form with an adsorption activity based on a water-soluble polysaccharide complex from the cones of European Spruce (Picea abies).Materials and methods. The samples of European Spruce (Picea abies) cones were collected on the territory of Ilyinsky district of the Perm Krai and used as plant raw materials. A water-soluble polysaccharide complex was obtained from the raw materials. In order to improve the technological properties of the substance, (WSPC) granulates were obtained. The granulates were hand-made by wet granulation. The adsorption activity of the obtained granules was determined by the ability to bind methylene blue.Results. As a result of the experiment it has been established, that the WSPC substance of European Spruce (Picea abies) cones needs to be improved in its technological properties. Granulation of the substance led to an improvement in technological properties and an increase in the adsorption activity in most of the selected compositions. It has also been shown that increased moisture content of granulate decreases its adsorption activity. A direct dependence of the adsorption activity on the concentration of the granulating liquid (with the exception of some granulates) has been revealed, but no significant effect of the size of the granulate particles on the manifestation of the adsorption effect has been reported. According to the results of the study, a dosage form “Capsules” has been proposed for the compositions that showed the best results of the adsorption activity, and their biopharmaceutical evaluation was carried out according to the disintegration test.Conclusion. Thus, a solid dosage form with an adsorption activity has been obtained. The study shows the prospects for further research on the preparation of the drug with an adsorption activity based on the water-soluble polysaccharide complex of European Spruce (Picea abies) cones.

scholarly journals RESEARCH ON THE SELECTION OF EXCIPIENTS AS THE RATIONALE FOR THE COMPOSITION OF THE TABLETS WITH DRY EXTRACT OF SANGUISORBA OFFICINALIS

2020 ◽  
Vol 2 ◽  
pp. 66-75
Author(s):  
Lyudmila Shulga ◽  
Kateryna Bezkrovna ◽  
Nina Domar
Keyword(s):  
Bulk Density ◽  
Microcrystalline Cellulose ◽  
Latin Square ◽  
Angle Of Repose ◽  
Direct Compression ◽  
Technological Properties ◽  
Dry Extract ◽  
Technological Characteristics ◽  
Hausner Ratio ◽  
Sanguisorba Officinalis

The aim. The aim of the research was to study the effect of different groups of excipients on the pharmaco-technological propertiesof the powder mass for tabletting in the development of the composition of the tablets with dry extract of Sanguisorba officinalis for complex therapy of the gastrointestinal tract diseases. Materials and methods. Objects of study - dry extract Sanguisorba officinalis, 25 excipients used in the production of tablets by the method of direct compression, grouped into five groups of factors (fillers based on sugars and microcrystalline cellulose, disintegrants, glidants and lubricants), samples of powder masses. Studies on the determination of pharmaco-technological properties (fluidity, bulk density, bulk density after shrinkage, degree of compressibility, Hausner ratio, and angle of repose) of the obtained powder masses were carried out according to the methods of the State Pharmacopoeia of Ukraine, Second edition. The method of mathematical planning of the experiment was used in the work, the obtained results were subjected to variance analysis, and the ranked series of advantages were placed, in which the excipients were placed in the sequence of their influence on the studied pharmaco-tecnological parameters. Results and discussion. The influence of excipients (factors) on the pharmaco-technological properties (responses) of the powdered tablet masses with the construction of ranked benefits was studied using a five-factor experiment, a hyper-Graeco-Latin square. The results of the analysis of variance showed that glidants have the greatest influence on the fluidity, the bulk density and the bulk density after shrinkage. Neusilin US 2 significantly affects the fluidity of the powder masses and Hausner ratio, the talc having the greatest effect on the bulk density and the bulk density after shrinkage of the powder masses. The representative of the disintegrants group – Sodium starch glycolate most influences the compressibility index, the sugar-based filler – Pearlitol 500 DC – on the angle of repose. Conclusions. The effect of 25 excipients on the pharmaco-technological characteristics of the powdered tablet masses with dry extract of Sanguisorba officinalis was studied. It was found that among the sugars-based fillers equally good results were shown in the powder masses with Compri sugar, Tablettose 80 and Pearlitol 500 DC; among the microcrystalline cellulose based fillers is Prosolv 90; among glidants – Neusilin US 2; no comparison was made of the disintegrants and lubricant excipients from the studied list of leader substances. The results of the studies indicate the possibility of obtaining tablets by the direct compression method, and further study of their pharmaco-technological characteristics will allow to establish the optimal composition of excipients.

Study of technological characteristics of the Health in gum® base for chewing gum

2020 ◽  
pp. 18-21
Author(s):  
E. Blynskaya ◽  
S. Tishkov ◽  
V. Bueva ◽  
K. Alekseev ◽  
V. Alekseev ◽  
...  
Keyword(s):  
Dosage Form ◽  
Patent Protection ◽  
Chewing Gum ◽  
Direct Compression ◽  
Technological Properties ◽  
Technological Characteristics ◽  
Chewing Gums

Medicated chewing gum is a convenient dosage form that allows to expand the range of medicines, ensure adherence of patients to the treatment and extend patent protection for well-known names of medicines. This article describes the technological properties of the Health in Gum® chewing gum base, which provides medicinal chewing gums with minimal addition of excipients by direct compression.

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