Treating pregnant women with highly active antiretroviral therapy

2007 ◽  
Vol 1 (2) ◽  
pp. 215-222
Author(s):  
Katherine M Coyne ◽  
Rachael Jones ◽  
David Hawkins
Keyword(s):  
Antiretroviral Therapy ◽  
Pregnant Women ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active

Prenatal screening of HIV positive pregnant women under HAART (highly active antiretroviral therapy)

2019 ◽  
Vol 234 ◽  
pp. e18
Author(s):  
Mircea Onofriescu ◽  
Dragos Nemescu ◽  
Adina Tanase ◽  
Anca Berescu ◽  
Mirabela Petica ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Pregnant Women ◽  
Highly Active Antiretroviral Therapy ◽  
Prenatal Screening ◽  
Hiv Positive ◽  
Highly Active

scholarly journals Fibrinolytic changes in pregnant women on highly active antiretroviral therapy

2015 ◽  
Vol 36 (2) ◽  
pp. 200-203 ◽  
Author(s):  
Odaburhine Osime ◽  
Joseph Ese-Onakewhor ◽  
Samson Kolade
Keyword(s):  
Antiretroviral Therapy ◽  
Pregnant Women ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active

Highly Active Antiretroviral Therapy Does Not Affect Mitochondrial β-Oxidation of Fatty Acids: An in Vitro Study in Fibroblasts

2008 ◽  
Vol 11 (1) ◽  
pp. 35-38
Author(s):  
Yasmeen M. Butt ◽  
Samira A. Kamrudin ◽  
Dinesh Rakheja
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Antiretroviral Therapy ◽  
Pregnant Women ◽  
Highly Active Antiretroviral Therapy ◽  
Culture Media ◽  
Antiretroviral Drugs ◽  
Acid Oxidation ◽  
Highly Active

Preeclampsia is a multifactorial pregnancy-specific disease. In some cases, severe preeclampsia and related disorders of acute fatty liver of pregnancy and hemolysis, elevated liver enzymes, low platelets syndrome are associated with inherited defects in mitochondrial β-oxidation of fatty acids, especially a deficiency of long-chain 3-hydroxyacyl coenzyme A dehydrogenase (LCHAD). Recently, an unexplained increase in the incidence of preeclampsia has been documented in human immunodeficiency virus (HIV)–infected pregnant women on treatment with highly active antiretroviral therapy (HAART). We performed this study to determine if antiretroviral drugs affect mitochondrial β-oxidation fatty acids in vitro. Two normal and 1 heterozygous LCHAD-deficient cell lines were exposed to up to 5 times the therapeutic concentrations of the following antiretroviral drugs: nevirapine, didanosine, lamivudine, and a combination of nelfinavir, zidovudine, and lamivudine. One homozygous LCHAD-deficient cell line served as the positive control. After exposure of the fibroblasts to these drugs for periods ranging from 2 to 10 days, accumulations of even-chain 3-hydroxy fatty acids (3-OH-C6 to 3-OH-C18) in the culture media were measured by stable-isotope dilution gas chromatography/mass spectrometry. Compared to the respective unexposed fibroblasts, there was no significant build-up of 3-hydroxy fatty acids in the culture media of normal or heterozygous LCHAD-deficient fibroblasts exposed to antiretroviral drugs. Our results show that the commonly used antiretroviral drugs do not adversely affect fatty acid oxidation in fibroblasts. Therefore, an altered fatty acid oxidation may not be the mechanism for the reported increased risk of preeclampsia in HIV-infected pregnant women on HAART.

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