Possibility of detecting intraductal papillary mucinous neoplasms using metabolite biomarkers for pancreatic cancer

2020 ◽  
Vol 14 (11) ◽  
pp. 1009-1020
Author(s):  
Ryota Nakano ◽  
Shin Nishiumi ◽  
Takashi Kobayashi ◽  
Takuya Ikegawa ◽  
Yuzo Kodama ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
High Risk ◽  
Multiple Logistic Regression Analysis ◽  
High Sensitivity ◽  
Plasma Samples ◽  
Multiple Logistic Regression ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Detection Model ◽  
High Risk Factors ◽  
Mucinous Neoplasms

Aim: The aim of this study was to identify whether metabolite biomarker candidates for pancreatic cancer (PC) could aid detection of intraductal papillary mucinous neoplasms (IPMN), recognized as high-risk factors for PC. Materials & methods: The 12 metabolite biomarker candidates, which were found to be useful to detect PC in our previous study, were evaluated for plasma samples from patients with PC (n = 44) or IPMN (n = 24) or healthy volunteers (n = 46). Results: Regarding the performance of individual biomarkers of PC and PC high-risk IPMN, lysine exhibited the best performance (sensitivity: 67.8%; specificity: 86.9%). The multiple logistic regression analysis-based detection model displayed high sensitivity and specificity values of 92.5 and 90.6%, respectively. Conclusion: Metabolite biomarker candidates for PC are useful for detecting high-risk IPMN, which can progress to PC.

scholarly journals SATB2 in Neoplasms of Lung, Pancreatobiliary, and Gastrointestinal Origins

2020 ◽  
Vol 155 (1) ◽  
pp. 124-132 ◽  
Author(s):  
Simona De Michele ◽  
Helen E Remotti ◽  
Armando Del Portillo ◽  
Stephen M Lagana ◽  
Matthias Szabolcs ◽  
...  
Keyword(s):  
Small Bowel ◽  
Colorectal Adenocarcinoma ◽  
High Sensitivity ◽  
Staining Intensity ◽  
Nuclear Staining ◽  
Intensity Analysis ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Score Threshold ◽  
Mucinous Neoplasms ◽  
Colorectal Origin

Abstract Objectives Special AT-rich binding protein 2 (SATB2) immunohistochemistry (IHC) has high sensitivity and specificity for colorectal adenocarcinoma (CRC), but data on its expression in specific subsets of pulmonary, gastric, small bowel, and pancreatobiliary adenocarcinomas (ADCAs) are relatively limited or discordant. We assessed SATB2 expression in a large cohort of ADCAs from these sites to determine its reliability in distinguishing CRC from them. Methods SATB2 IHC was performed on 335 neoplasms, including 40 lung ADCAs, 165 pancreatobiliary neoplasms (34 intraductal papillary mucinous neoplasms [IPMNs], 19 pancreatic ADCAs, 112 cholangiocarcinomas [CCs]), and 35 gastric, 13 small bowel, 36 ampullary (AMP), and 46 CRC ADCAs. The cases were evaluated for positivity (defined as ≥5% nuclear staining), and an H-score was calculated based on the percentage of SATB2+ cells and staining intensity. Analysis was performed to determine the optimal H-score threshold to separate CRC and non-CRC. Results SATB2 was positive in 3% of lung, 2% of CC, 17% of gastric, 38% of small bowel, and 6% of AMP ADCAs. All pancreatic ADCA/IPMNs were negative, and 87% CRCs were positive. Conclusions SATB2 is not entirely specific for colorectal origin and can be expressed in a subset of gastrointestinal ADCAs. It is most useful in the differential of CRC vs lung and pancreatobiliary ADCAs.

Patients with pancreatic intraductal papillary mucinous neoplasms are at high risk of colorectal cancer development

Surgery ◽  
2006 ◽  
Vol 139 (6) ◽  
pp. 749-754 ◽  
Author(s):  
H EGUCHI ◽  
O ISHIKAWA ◽  
H OHIGASHI ◽  
Y TOMIMARU ◽  
Y SASAKI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Cancer Development ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms

Cancer of the Pancreas: Clinical Outcome in 76 Cases

1986 ◽  
Vol 72 (6) ◽  
pp. 601-607 ◽  
Author(s):  
Vittorio Pugliese ◽  
Sebastiano Saccomanno ◽  
Luigina Bonelli ◽  
Daniela Barone ◽  
Massimo Conio ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
High Risk ◽  
Clinical Outcome ◽  
Clinical Presentation ◽  
High Sensitivity ◽  
Radical Resection ◽  
Final Diagnosis ◽  
Diagnostic Techniques ◽  
Tissue Diagnosis ◽  
Cancer Of The Pancreas

A final diagnosis of pancreatic cancer was established in 76 consecutive patients during 4 years. The clinical outcome was evaluated retrospectively, as well as clinical presentation and its impact on the rate of resectability. Even though the diagnostic techniques showed a high sensitivity, only 18.4% of patients had a radical resection performed. In 77.6% of the cases a tissue diagnosis had been obtained. However, in only 1/5 of them was the tissue proof obtained preoperatively. This review confirms that the survival of patients with pancreatic cancer is poor, with slight advantages in the few resectable cases. Therefore, an earlier diagnosis should be attempted in high-risk symptomatic patients, selected by means of nonaggressive tests and evaluated by means of more accurate diagnostic techniques, when suitable.

Long non-coding RNA HSAT II as a new biomarker for the identification of high risk intraductal papillary mucinous neoplasms (IPMNs).

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e15246-e15246
Author(s):  
Francesco Pantano ◽  
Giuseppe Perrone ◽  
Bruno Vincenzi ◽  
Michele Iuliani ◽  
Marco Fioramonti ◽  
...  
Keyword(s):  
High Risk ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Non Coding Rna ◽  
Mucinous Neoplasms ◽  
Long Non Coding Rna

Noninvasive Discrimination of Low and High-risk Pancreatic Intraductal Papillary Mucinous Neoplasms

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Susanne Roth ◽  
Promita Bose ◽  
Mohamed S. S. Alhamdani ◽  
Shakhawan A. Mustafa ◽  
Christine Tjaden ◽  
...  
Keyword(s):  
High Risk ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms

scholarly journals Metachronous multicentric pancreatic cancer with multiple intraductal papillary mucinous neoplasms (IPMN)

Suizo ◽  
2016 ◽  
Vol 31 (1) ◽  
pp. 93-100
Author(s):  
Mitsuhiro SHIMURA ◽  
Masamichi MIZUMA ◽  
Takaho OKADA ◽  
Munetoshi KATAGIRI ◽  
Naoaki SAKATA ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Mucinous Neoplasms
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