New biomarkers to fight urogenital schistosomiasis: a major neglected tropical disease

2014 ◽  
Vol 8 (9) ◽  
pp. 1061-1063 ◽  
Author(s):  
Mónica C Botelho ◽  
Mário Sousa
Keyword(s):  
Tropical Disease ◽  
Neglected Tropical Disease ◽  
Urogenital Schistosomiasis ◽  
New Biomarkers

scholarly journals In-depth proteomic characterization of Schistosoma haematobium: towards the development of new tools for elimination

2018 ◽  
Author(s):  
Javier Sotillo ◽  
Mark S. Pearson ◽  
Luke Becker ◽  
Gebeyaw G. Mekonnen ◽  
Abena S. Amoah ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Schistosoma Haematobium ◽  
Human Subjects ◽  
Antibody Responses ◽  
Tropical Disease ◽  
Neglected Tropical Disease ◽  
Urogenital Schistosomiasis ◽  
Clinical Complications

AbstractBackgroundSchistosomiasis is a neglected disease affecting hundreds of millions worldwide. Of the three main species affecting humans, Schistosoma haematobium is the most common, and is the leading cause of urogenital schistosomiasis. S. haematobium infection can cause different urogential clinical complications, particularly in the bladder, and furthermore, this parasite has been strongly linked with squamous cell carcinoma. A comprehensive analysis of the molecular composition of its different proteomes will contribute to developing new tools against this devastating disease.Methods and FindingsBy combining a comprehensive protein fractionation approach consisting of OFFGEL electrophoresis with high-throughput mass spectrometry, we have performed the first in-depth characterisation of the different discrete proteomes of S. haematobium that are predicted to interact with human host tissues, including the secreted and tegumental proteomes of adult flukes and secreted and soluble egg proteomes. A total of 662, 239, 210 and 138 proteins were found in the adult tegument, adult secreted, soluble egg and secreted egg proteomes, respectively. In addition, we probed these distinct proteomes with urine to assess urinary antibody responses from naturally infected human subjects with different infection intensities, and identified adult fluke secreted and tegument extracts as being the best predictors of infection.ConclusionWe provide a comprehensive dataset of proteins from the adult and egg stages of S. haematobium and highlight their utility as diagnostic markers of infection intensity for the development of novel tools to control this important neglected tropical disease.Author SummarySchistosomiasis is a neglected tropical disease affecting millions of people worldwide. Of the main three species affecting humans, Schistosoma haematobium is the most common, and is the leading cause of urogenital schistosomiasis. This parasite can cause a range of clinical complications associated with bladder pathogenesis, including squamous cell carcinoma as well as genital malignancy in women. Herein, we have performed the first comprehensive characterisation of the proteins implicated in host-parasite interactions (secreted and surface proteins from the adult flukes and secreted and soluble egg proteins) in order to advance our understanding of the parasite’s biology. Furthermore, we have characterised the different antibody responses in urine from infected human subjects from an endemic area presenting different infection intensities. The data obtained in this study can be used as a first step towards the development of novel tools for the control of urogenital schistosomiasis.

scholarly journals Evaluating the potential impact of interruptions to neglected tropical disease programmes due to COVID-19

2021 ◽  
Vol 115 (3) ◽  
pp. 201-204
Author(s):  
T Déirdre Hollingsworth ◽  
Pauline Mwinzi ◽  
Andreia Vasconcelos ◽  
Sake J de Vlas
Keyword(s):  
Tropical Disease ◽  
Neglected Tropical Disease ◽  
Potential Impact

scholarly journals Using Co-authorship Networks to Map and Analyse Global Neglected Tropical Disease Research with an Affiliation to Germany

2015 ◽  
Vol 9 (12) ◽  
pp. e0004182 ◽  
Author(s):  
Max Ernst Bender ◽  
Suzanne Edwards ◽  
Peter von Philipsborn ◽  
Fridolin Steinbeis ◽  
Thomas Keil ◽  
...  
Keyword(s):  
Tropical Disease ◽  
Neglected Tropical Disease ◽  
Disease Research

scholarly journals Genome Sequence ofMadurella mycetomatismm55, Isolated from a Human Mycetoma Case in Sudan

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Sandra Smit ◽  
Martijn F. L. Derks ◽  
Sander Bervoets ◽  
Ahmed Fahal ◽  
Willem van Leeuwen ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Causative Agent ◽  
Tropical Disease ◽  
Neglected Tropical Disease ◽  
Madurella Mycetomatis

We present the first genome sequence for a strain of the main mycetoma causative agent,Madurella mycetomatis. This 36.7-Mb genome sequence will offer new insights into the pathogenesis of mycetoma, and it will contribute to the development of better therapies for this neglected tropical disease.

scholarly journals Distinct Presentation of a Neglected Tropical Disease on Screening Colonoscopy

2018 ◽  
Vol 16 (9) ◽  
pp. e91-e92
Author(s):  
Rebekah S. Wieland ◽  
Richard S. Zubarik ◽  
Maryam J. Zenali
Keyword(s):  
Tropical Disease ◽  
Screening Colonoscopy ◽  
Neglected Tropical Disease

scholarly journals Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art

Parasitology ◽  
2017 ◽  
Vol 145 (2) ◽  
pp. 219-236 ◽  
Author(s):  
REBECCA L. CHARLTON ◽  
BARTIRA ROSSI-BERGMANN ◽  
PAUL W. DENNY ◽  
PATRICK G. STEEL
Keyword(s):  
State Of The Art ◽  
Drug Repurposing ◽  
Tropical Disease ◽  
Neglected Tropical Disease ◽  
Current State ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Vector Borne ◽  
Faster Development ◽  
New Treatments

SUMMARYLeishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs. There are 1·3 million new cases each year causing considerable socio-economic hardship, best measured in 2·4 million disability adjusted life years, with greatest impact on the poorest communities, which means that desperately needed new antileishmanial treatments have to be both affordable and accessible. Established medicines with cheaper and faster development times may hold the cure for this neglected tropical disease. This concept of using old drugs for new diseases may not be novel but, with the ambitious target of controlling or eradicating tropical diseases by 2020, this strategy is still an important one. In this review, we will explore the current state-of-the-art of drug repurposing strategies in the search for new treatments for leishmaniasis.

scholarly journals Colaboración entre el sector de WASH y el sector de la salud: Guía práctica para los programas de lucha contra las enfermedades tropicales desatendidas.

2020 ◽  
Keyword(s):  
World Health Organization ◽  
Tropical Disease ◽  
World Health ◽  
Neglected Tropical Disease ◽  
Working Together ◽  
Health Organization ◽  
Buenas Prácticas

Este documento presenta un conjunto de herramientas para ayudar a los países y los programas de lucha contra la ETD, a colaborar con la comunidad relacionada con las acciones de agua, saneamiento e higiene, y guía en la creación de alianzas, en la movilización de recursos y en el diseño, la aplicación y la evaluación de las intervenciones. Más que una guía de “buenas prácticas”, se trata de un conjunto de herramientas basadas en la experiencia adquirida en la realidad de un programa. Se espera que los interesados en usar este documento puedan elegir las herramientas y adaptarlas a sus necesidades y al contexto local. Estas herramientas ayudarán a 1) crear alianzas multisectoriales con los interesados directos clave: ministerios, agencias de WASH nacionales y locales, empresas, grupos locales activos en cuestiones de salud, expertos en cambio de comportamientos y en comunicación, etc.; 2) a formar estructuras de programa inteligentes centradas en la rendición de cuentas y en los objetivos comunes; 3) a establecer un método de programación adaptativo y flexible; 4) a garantizar la sostenibilidad mediante la creación de capacidad local a todos los niveles; y 5) a brindar apoyo y complementar las intervenciones clínicas y de salud pública en la lucha contra las EID. Version oficial en Españo de la obra original en inglés: WASH and health working together: A 'how-to' guide for Neglected Tropical Disease programmes. © World Health Organization 2019. ISBN: 978-92-4-151500-9.

Sign in / Sign up

Export Citation Format

Share Document