Genome-wide DNA methylation changes in placenta tissues associated with small for gestational age newborns; cohort study in the Chinese population

Aim: To investigate DNA methylation changes in placenta tissues associated with small for gestational age (SGA). Materials & methods: A prospective cohort study consisting of 1292 pregnant women from China (including 39 SGA with placenta tissues) was performed, microarray and pyrosequencing were conducted. Results: Total 2012 methylation variable positions stood out from all probes (p < 0.05; Δβ > 0.2). In SGA cases, a CpG site within ANKRD20B showed lower methylation level (p = 0.032) than appropriate for gestational age in validation cohort. Five sites within FAM198A (p = 0.047, 0.050, 0.039, 0.026 and 0.043, respectively) had a reduced methylation in male newborns whose mother had preconception folic acid supplementation. Conclusion: DNA methylation changes in placenta tissues may be associated with SGA, maternal preconception folic acid supplementation status and also be fetal sex-specific.

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Pre-conceptional intake of folic acid supplements is inversely associated with risk of preterm birth and small-for-gestational-age birth: a prospective cohort study

British Journal Of Nutrition ◽

10.1017/s0007114515004663 ◽

2015 ◽

Vol 115 (3) ◽

pp. 509-516 ◽

Cited By ~ 17

Author(s):

Ju-Sheng Zheng ◽

Yuhong Guan ◽

Yimin Zhao ◽

Wei Zhao ◽

Xuejuan Tang ◽

...

Keyword(s):

Cohort Study ◽

Folic Acid ◽

Preterm Birth ◽

Birth Cohort ◽

Gestational Age ◽

Small For Gestational Age ◽

Pregnancy Outcomes ◽

Lower Risk ◽

Folic Acid Supplementation ◽

Acid Supplementation

AbstractAssociations of folic acid supplementation with risk of preterm birth (PTB) and small-for-gestational-age (SGA) birth were unclear for the Chinese populations. The aim of the present study was to investigate the associations in a large Chinese prospective cohort study: the Jiaxing Birth Cohort. In the Jiaxing Birth Cohort, 240 954 pregnant women visited local clinics or hospitals within their first trimester in Southeast China during 1999–2012. Information on anthropometric parameters, folic acid supplementation and other maternal characteristics were collected by in-person interviews during their first visit. Pregnancy outcomes were recorded during the follow-up of these participants. Multinomial logistic regression was used to examine the association of folic acid supplementation with pregnancy outcomes. The prevalence of folic acid supplementation was 24·9 % in the cohort. The prevalence of PTB and SGA birth was 3·48 and 9·2 %, respectively. Pre-conceptional folic acid supplementation was associated with 8 % lower risk of PTB (relative risk (RR) 0·92; 95 % CI 0·85, 1·00; P=0·04) and 19 % lower risk of SGA birth (RR 0·81; 95 % CI 0·70, 0·95; P=0·008), compared with non-users. Higher frequency of pre-conceptional folic acid use was associated with lower risk of PTB (Ptrend=0·032) and SGA birth (Ptrend=0·046). No significant association between post-conceptional initiation of folic acid supplementation and either outcome was observed. In conclusion, the present study suggests an association between pre-conceptional, but not post-conceptional, folic acid supplementation and lower risk of PTB and SGA birth in the Jiaxing Birth Cohort. Further research in other cohorts of large sample size is needed to replicate these findings.

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Homocysteine in small-for-gestational age and appropriate-for-gestational age preterm neonates from mothers receiving folic acid supplementation

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2010.235 ◽

2010 ◽

Vol 48 (8) ◽

Cited By ~ 8

Author(s):

Thushari S. Gomes ◽

Ulrike Lindner ◽

Kamani H. Tennekoon ◽

Wimal Karandagoda ◽

Ludwig Gortner ◽

...

Keyword(s):

Folic Acid ◽

Gestational Age ◽

Small For Gestational Age ◽

Folic Acid Supplementation ◽

Preterm Neonates ◽

Acid Supplementation ◽

Appropriate For Gestational Age

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Folic acid supplementation, dietary folate intake and risk of small for gestational age in China

Public Health Nutrition ◽

10.1017/s1368980019003331 ◽

2019 ◽

Vol 23 (11) ◽

pp. 1965-1973

Author(s):

Huaqi Guo ◽

Baohong Mao ◽

Meng Wang ◽

Qing Liu ◽

Liping Yang ◽

...

Keyword(s):

Folic Acid ◽

Gestational Age ◽

Small For Gestational Age ◽

Folic Acid Supplementation ◽

Folate Intake ◽

Care Hospital ◽

Dietary Folate ◽

Acid Supplementation ◽

Dietary Folate Intake ◽

Reduced Risk

AbstractObjective:To investigate the hypothesis that folic acid supplementation and dietary folate intake before conception and during pregnancy reduce the risk of small for gestational age (SGA) and to examine the joint effect of folic acid supplementation and dietary folate intake on the risk of SGA.Design:Participants were interviewed by trained study interviewers using a standardized and structured questionnaire. Information on birth outcomes and maternal complications was abstracted from medical records and dietary information was collected via a semi-quantitative FFQ before conception and during pregnancy.Setting:A birth cohort data analysis using the 2010–2012 Gansu Provincial Maternity and Child Care Hospital.Participants:Women (n 8758) and their children enrolled in the study.Results:Folic acid supplementation was associated with a reduced risk of SGA (OR = 0·72, 95 % CI 0·60, 0·86), with the reduced risk seen mainly for SGA at ≥37 weeks of gestational age (OR = 0·70, 95 % CI 0·58, 0·85) and nulliparous SGA (OR = 0·67, 95 % CI 0·54, 0·84). There was no significant association between dietary folate intake and SGA risk.Conclusions:Our study suggested that folic acid supplementation was associated with a reduced risk of SGA and the risk varied by preterm status and parity.

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